PR8A9_RAT
ID PR8A9_RAT Reviewed; 241 AA.
AC Q920I0; A1L118; Q498N7; Q80ZD4; Q920H9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Prolactin-8A9;
DE AltName: Full=Placental prolactin-like protein C2;
DE Short=PLP-C2;
DE Short=PRL-like protein C2;
DE AltName: Full=Prolactin-like protein C-beta;
DE Short=PLP C-beta;
DE Flags: Precursor;
GN Name=Prl8a9; Synonyms=Prlpc2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=10965907; DOI=10.1210/endo.141.9.7635;
RA Hwang I.-T., Lee Y.-H., Moon B.-C., Ahn K.-Y., Lee S.-W., Chun J.-Y.;
RT "Identification and characterization of a new member of the placental
RT prolactin-like protein-C (PLP-C) subfamily, PLP-Cbeta.";
RL Endocrinology 141:3343-3352(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=Prolactin-like protein C beta1-a;
CC IsoId=Q920I0-1; Sequence=Displayed;
CC Name=2; Synonyms=Prolactin-like protein C beta2;
CC IsoId=Q920I0-2; Sequence=VSP_016759;
CC Name=3; Synonyms=Prolactin-like protein C beta1-b;
CC IsoId=Q920I0-3; Sequence=VSP_016758;
CC -!- TISSUE SPECIFICITY: Detected only in placenta.
CC {ECO:0000269|PubMed:10965907}.
CC -!- MISCELLANEOUS: [Isoform 1]: Major form.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF239745; AAL05068.1; -; mRNA.
DR EMBL; AF239746; AAO49169.1; -; mRNA.
DR EMBL; AF239747; AAO49170.1; -; mRNA.
DR EMBL; AF239748; AAL05069.1; -; mRNA.
DR EMBL; BC100138; AAI00139.2; -; mRNA.
DR EMBL; BC127474; AAI27475.1; -; mRNA.
DR RefSeq; NP_599212.1; NM_134385.2. [Q920I0-1]
DR RefSeq; XP_006253966.1; XM_006253904.1. [Q920I0-3]
DR RefSeq; XP_006253967.1; XM_006253905.1. [Q920I0-2]
DR AlphaFoldDB; Q920I0; -.
DR SMR; Q920I0; -.
DR STRING; 10116.ENSRNOP00000038096; -.
DR GlyGen; Q920I0; 2 sites.
DR iPTMnet; Q920I0; -.
DR PhosphoSitePlus; Q920I0; -.
DR PaxDb; Q920I0; -.
DR Ensembl; ENSRNOT00000034490; ENSRNOP00000038096; ENSRNOG00000024843. [Q920I0-1]
DR Ensembl; ENSRNOT00000104281; ENSRNOP00000096984; ENSRNOG00000024843. [Q920I0-2]
DR GeneID; 171406; -.
DR KEGG; rno:171406; -.
DR UCSC; RGD:619862; rat. [Q920I0-1]
DR CTD; 67310; -.
DR RGD; 619862; Prl8a9.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; Q920I0; -.
DR OMA; TFNSAMQ; -.
DR PhylomeDB; Q920I0; -.
DR TreeFam; TF332592; -.
DR PRO; PR:Q920I0; -.
DR Proteomes; UP000002494; Chromosome 17.
DR ExpressionAtlas; Q920I0; baseline and differential.
DR Genevisible; Q920I0; RN.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..241
FT /note="Prolactin-8A9"
FT /id="PRO_0000045328"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..41
FT /evidence="ECO:0000255"
FT DISULFID 101..217
FT /evidence="ECO:0000250"
FT DISULFID 234..241
FT /evidence="ECO:0000250"
FT VAR_SEQ 11..12
FT /note="SG -> C (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10965907"
FT /id="VSP_016758"
FT VAR_SEQ 70..82
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10965907"
FT /id="VSP_016759"
SQ SEQUENCE 241 AA; 27736 MW; F7D5494AA7D4212B CRC64;
MELPLSQAQF SGTFLMLAVS NMLLWEKVSS IPACLAEEGG CWNPIVETFN SAMQRGETLR
NLADQLYTEL YHNQFSSEQF LALNSKLIRR DKTAVRAGTY CHSTLSNSPD GETKHADVET
EKYLKMLINF VGAWISPLYH LVIELSAMQD VPETILSKAK DIEENKRELL DDLKWILTKV
YPTAEMKEEF PSWEHLSFLK SSNKDSKFLA MFNLSKCIYN ETYYILFYLR TLKCHITGKD
C
