PRA10_HUMAN
ID PRA10_HUMAN Reviewed; 474 AA.
AC O60809; Q2M1V2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 4.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=PRAME family member 10 {ECO:0000312|HGNC:HGNC:27997};
GN Name=PRAMEF10 {ECO:0000312|HGNC:HGNC:27997};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-144 AND ALA-306.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-459, AND VARIANTS HIS-144 AND
RP GLY-402.
RA Rhodes S.;
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AC245034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL022101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112208; AAI12209.1; -; mRNA.
DR EMBL; BC112210; AAI12211.1; -; mRNA.
DR EMBL; AL049682; CAB41254.1; -; mRNA.
DR CCDS; CCDS41255.1; -.
DR RefSeq; NP_001034450.3; NM_001039361.4.
DR AlphaFoldDB; O60809; -.
DR IntAct; O60809; 2.
DR STRING; 9606.ENSP00000235347; -.
DR iPTMnet; O60809; -.
DR PhosphoSitePlus; O60809; -.
DR BioMuta; PRAMEF10; -.
DR MassIVE; O60809; -.
DR PaxDb; O60809; -.
DR PeptideAtlas; O60809; -.
DR PRIDE; O60809; -.
DR Antibodypedia; 28586; 78 antibodies from 17 providers.
DR DNASU; 343071; -.
DR Ensembl; ENST00000235347.4; ENSP00000235347.4; ENSG00000187545.5.
DR Ensembl; ENST00000632873.1; ENSP00000488485.1; ENSG00000282663.1.
DR GeneID; 343071; -.
DR KEGG; hsa:343071; -.
DR MANE-Select; ENST00000235347.4; ENSP00000235347.4; NM_001039361.4; NP_001034450.3.
DR UCSC; uc031tpi.2; human.
DR CTD; 343071; -.
DR GeneCards; PRAMEF10; -.
DR HGNC; HGNC:27997; PRAMEF10.
DR HPA; ENSG00000187545; Tissue enriched (liver).
DR neXtProt; NX_O60809; -.
DR OpenTargets; ENSG00000187545; -.
DR PharmGKB; PA142671147; -.
DR VEuPathDB; HostDB:ENSG00000187545; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; O60809; -.
DR OMA; NRGHINW; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; O60809; -.
DR SignaLink; O60809; -.
DR BioGRID-ORCS; 343071; 17 hits in 982 CRISPR screens.
DR GenomeRNAi; 343071; -.
DR Pharos; O60809; Tdark.
DR PRO; PR:O60809; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O60809; protein.
DR Bgee; ENSG00000187545; Expressed in liver and 1 other tissue.
DR Genevisible; O60809; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..474
FT /note="PRAME family member 10"
FT /id="PRO_0000156984"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..265
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 266..291
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 292..323
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 324..342
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 348..375
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 376..400
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT VARIANT 99
FT /note="K -> I (in dbSNP:rs3121398)"
FT /id="VAR_029104"
FT VARIANT 144
FT /note="R -> H (in dbSNP:rs2797709)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_029105"
FT VARIANT 306
FT /note="T -> A (in dbSNP:rs848424)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029106"
FT VARIANT 402
FT /note="R -> G (in dbSNP:rs1736772)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029107"
FT CONFLICT 63
FT /note="R -> S (in Ref. 2; AAI12209/AAI12211 and 3;
FT CAB41254)"
FT /evidence="ECO:0000305"
FT CONFLICT 73
FT /note="P -> L (in Ref. 2; AAI12209/AAI12211 and 3;
FT CAB41254)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="N -> H (in Ref. 2; AAI12209/AAI12211 and 3;
FT CAB41254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 474 AA; 55211 MW; 55DEAAD7962DC5E0 CRC64;
MSLQAPSRLL ELAGQSLLRN QFLTIFTLDE LPREVFPLMF MEAFSMRRFE ALKLMVQAWP
FLRLPLGSLM KTPHLETLQA VLRGLDTLVA QKVRPRRWKL QVLDLRDVDE NFWTIWSGAR
VLSCSPEAMS KRQTVEDCPR MGERQPLKVF IDLCLKESTL DECLSYLFGW IHYRRGLVHL
CCSKVQNYSM PTSSFRNLLE RIYPDSIQEL EVWKKCSLNK TGKFAPYLSQ MSNLRELFLA
FGYERELYVS VQWPCIPDLD SPFLCLYYPQ MLYIKKISNI KEHLEHLLRY LKNPLGAFIF
SDAYLTDRDM ECLSQYPSLS QLKELRLIHI LMWTTNLEPL GVLLEKVAAT LKTLVLKDCR
IQDPQLRVLL PALSHCSQLT TFNFHGNETS MNALKDLLRH TRGLSKLGLE LYPAPLESLD
YKGHVNWEIL TPIRAELMRT LREVRQPKRI FFGPVPCPNC GSWPSEKVDF HLCS
