PRA11_HUMAN
ID PRA11_HUMAN Reviewed; 478 AA.
AC O60813; A0A087WW85; B7ZMC2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 5.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=PRAME family member 11 {ECO:0000312|HGNC:HGNC:14086};
GN Name=PRAMEF11 {ECO:0000312|HGNC:HGNC:14086};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-477.
RA Rhodes S.;
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC245034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC144426; AAI44427.1; -; mRNA.
DR EMBL; AL049680; CAB41252.1; -; mRNA.
DR CCDS; CCDS53268.2; -.
DR RefSeq; NP_001139816.2; NM_001146344.2.
DR RefSeq; XP_011539781.1; XM_011541479.2.
DR AlphaFoldDB; O60813; -.
DR STRING; 9606.ENSP00000480027; -.
DR PhosphoSitePlus; O60813; -.
DR BioMuta; PRAMEF11; -.
DR MassIVE; O60813; -.
DR PaxDb; O60813; -.
DR PeptideAtlas; O60813; -.
DR PRIDE; O60813; -.
DR Antibodypedia; 73339; 60 antibodies from 11 providers.
DR DNASU; 440560; -.
DR Ensembl; ENST00000619922.1; ENSP00000480027.2; ENSG00000239810.3.
DR Ensembl; ENST00000633392.1; ENSP00000488512.1; ENSG00000281934.1.
DR GeneID; 440560; -.
DR KEGG; hsa:440560; -.
DR MANE-Select; ENST00000619922.1; ENSP00000480027.2; NM_001146344.3; NP_001139816.2.
DR UCSC; uc031tph.2; human.
DR CTD; 440560; -.
DR GeneCards; PRAMEF11; -.
DR HGNC; HGNC:14086; PRAMEF11.
DR HPA; ENSG00000239810; Not detected.
DR neXtProt; NX_O60813; -.
DR OpenTargets; ENSG00000239810; -.
DR PharmGKB; PA142671148; -.
DR VEuPathDB; HostDB:ENSG00000239810; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR InParanoid; O60813; -.
DR OMA; CYTTHET; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; O60813; -.
DR BioGRID-ORCS; 440560; 57 hits in 995 CRISPR screens.
DR GenomeRNAi; 440560; -.
DR Pharos; O60813; Tdark.
DR PRO; PR:O60813; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O60813; protein.
DR Bgee; ENSG00000239810; Expressed in left testis and 1 other tissue.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..478
FT /note="PRAME family member 11"
FT /id="PRO_0000156985"
FT REPEAT 99..126
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 181..205
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 206..232
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 233..268
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 269..294
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 295..326
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 327..347
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 351..378
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 379..403
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT CONFLICT 135
FT /note="K -> T (in Ref. 3; CAB41252 and 2; AAI44427)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="G -> E (in Ref. 3; CAB41252)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="L -> M (in Ref. 2; AAI44427)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="L -> V (in Ref. 2; AAI44427)"
FT /evidence="ECO:0000305"
FT CONFLICT 419
FT /note="Q -> R (in Ref. 2; AAI44427)"
FT /evidence="ECO:0000305"
FT CONFLICT 442..443
FT /note="KK -> NR (in Ref. 2; AAI44427)"
FT /evidence="ECO:0000305"
FT CONFLICT 446
FT /note="H -> D (in Ref. 2; AAI44427)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 478 AA; 55344 MW; C22EF55879C975C9 CRC64;
MKMSIRIPPR LLELAGRSLL RDQALAVSTL EELPTELFPP LFMEAFSRRR CEALKLMVQA
WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LTQGVRPRRW KLQVLDLQDV CENFWMVWSE
AMAHGCFLNA KRNKKPVQDC PRMRGRQPLT VFVELWLKNR TLDEYLTCLL LWVKQRRDLL
HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWIL PILTQFTPYL GHLRNLQKLV
LSHMDVSRYV SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD
DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL LSHTIILKNL CLELYPAPQE
SYGADGTLCW SRFAQIRAEL MKKVRHLRHP KRILFCTDNC PDHGDRSFYD LEADQYCC
