PRA12_HUMAN
ID PRA12_HUMAN Reviewed; 483 AA.
AC O95522;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=PRAME family member 12 {ECO:0000312|HGNC:HGNC:22125};
GN Name=PRAMEF12 {ECO:0000312|HGNC:HGNC:22125};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AC244670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL023753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41254.1; -.
DR RefSeq; NP_001074299.2; NM_001080830.4.
DR AlphaFoldDB; O95522; -.
DR STRING; 9606.ENSP00000350358; -.
DR iPTMnet; O95522; -.
DR PhosphoSitePlus; O95522; -.
DR BioMuta; PRAMEF12; -.
DR MassIVE; O95522; -.
DR PaxDb; O95522; -.
DR PeptideAtlas; O95522; -.
DR PRIDE; O95522; -.
DR ProteomicsDB; 50934; -.
DR Antibodypedia; 48073; 60 antibodies from 14 providers.
DR DNASU; 390999; -.
DR Ensembl; ENST00000357726.5; ENSP00000350358.4; ENSG00000116726.5.
DR GeneID; 390999; -.
DR KEGG; hsa:390999; -.
DR MANE-Select; ENST00000357726.5; ENSP00000350358.4; NM_001080830.5; NP_001074299.2.
DR UCSC; uc001aui.5; human.
DR CTD; 390999; -.
DR DisGeNET; 390999; -.
DR GeneCards; PRAMEF12; -.
DR HGNC; HGNC:22125; PRAMEF12.
DR HPA; ENSG00000116726; Not detected.
DR neXtProt; NX_O95522; -.
DR OpenTargets; ENSG00000116726; -.
DR PharmGKB; PA145148158; -.
DR VEuPathDB; HostDB:ENSG00000116726; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; O95522; -.
DR OMA; NTVELDC; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; O95522; -.
DR BioGRID-ORCS; 390999; 16 hits in 1061 CRISPR screens.
DR ChiTaRS; PRAMEF12; human.
DR GenomeRNAi; 390999; -.
DR Pharos; O95522; Tdark.
DR PRO; PR:O95522; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O95522; protein.
DR Genevisible; O95522; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..483
FT /note="PRAME family member 12"
FT /id="PRO_0000156986"
FT REPEAT 97..122
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 177..201
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 202..228
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 229..264
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 265..290
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 291..322
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 323..341
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 347..374
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 375..399
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT VARIANT 53
FT /note="T -> K (in dbSNP:rs17346571)"
FT /id="VAR_053608"
FT VARIANT 157
FT /note="T -> M (in dbSNP:rs1812242)"
FT /id="VAR_053609"
SQ SEQUENCE 483 AA; 54633 MW; 13B493FE043B119C CRC64;
MSLQAPPRLL ELAEQSLLRD RALAIPTLEE LPRELFPPLF MEAFTRRCCE TLTTMVQAWP
FTCLPLGSLM KSCNLEIFRA VLEGLDALLA QKVRPRRWKL QVLDLRNVDE NFWGIWSGAS
ALSPEALSKR RTAGNCPRPG GQQPLMVILD LCFKNGTLDE CLTHFLEWGK QRKGLLHVCC
KELQIFGIAI HRIIEVLNTV ELDCIQEVEV CCPWELSILI RFAPYLGQMR NLRKLVLFNI
HVSACIPLDR KEQFVIQFTS QFLKLDYFQK LYMHSVSFLE GHLDQLLRCL QAPLETVVMT
ECLLSESDLK HLSWCPSIRQ LKELDLRGIT LTHFSPEPLS VLLEQAEATL QTLDLEDCGI
VDSQLSAILP ALSRCSQLST FSFCGNLISM AALENLLRHT VGLSKLSLEL YPAPLESYDA
QGALCWGRFS QLGAELMKTL RDLRQPKIIV FSTVPCPRCG IRASYDLEPS HCLLNACCQG
GFI
