PRA13_HUMAN
ID PRA13_HUMAN Reviewed; 474 AA.
AC Q5VWM6;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Putative PRAME family member 13 {ECO:0000305};
GN Name=PRAMEF13 {ECO:0000312|HGNC:HGNC:13262};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC244216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC245056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001278309.1; NM_001291380.1.
DR AlphaFoldDB; Q5VWM6; -.
DR SMR; Q5VWM6; -.
DR iPTMnet; Q5VWM6; -.
DR PhosphoSitePlus; Q5VWM6; -.
DR BioMuta; PRAMEF13; -.
DR DMDM; 74747421; -.
DR PeptideAtlas; Q5VWM6; -.
DR PRIDE; Q5VWM6; -.
DR Antibodypedia; 78644; 7 antibodies from 1 providers.
DR DNASU; 400736; -.
DR Ensembl; ENST00000625019.3; ENSP00000491259.1; ENSG00000279169.3.
DR Ensembl; ENST00000632392.3; ENSP00000492522.1; ENSG00000282741.3.
DR GeneID; 400736; -.
DR KEGG; hsa:400736; -.
DR MANE-Select; ENST00000625019.3; ENSP00000491259.1; NM_001291380.1; NP_001278309.1.
DR CTD; 400736; -.
DR DisGeNET; 400736; -.
DR GeneCards; PRAMEF13; -.
DR HGNC; HGNC:13262; PRAMEF13.
DR HPA; ENSG00000279169; Not detected.
DR neXtProt; NX_Q5VWM6; -.
DR OpenTargets; ENSG00000279169; -.
DR PharmGKB; PA145148169; -.
DR VEuPathDB; HostDB:ENSG00000279169; -.
DR GeneTree; ENSGT01030000234531; -.
DR InParanoid; Q5VWM6; -.
DR OMA; CHHSTSD; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; Q5VWM6; -.
DR BioGRID-ORCS; 400736; 20 hits in 568 CRISPR screens.
DR GenomeRNAi; 400736; -.
DR Pharos; Q5VWM6; Tdark.
DR PRO; PR:Q5VWM6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VWM6; protein.
DR Bgee; ENSG00000279169; Expressed in testis and 1 other tissue.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 5: Uncertain;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..474
FT /note="Putative PRAME family member 13"
FT /id="PRO_0000290161"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..265
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 266..291
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 292..323
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 324..342
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 348..375
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 376..400
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 474 AA; 54914 MW; 834973B57E6266F6 CRC64;
MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF MEAFRRRHFQ TLTVMVQAWP
FTCLPLGSLM KTLHLETLKA LLEGLHMLLT QKDRPRRRKL QVLDLRDVDE NFWARWPGAW
ALSCFPETMS KRQTAEDRPR MGEHQPLKVF IDICLKEIPQ DECLRYLFQW VYQRRGLVHL
CCSKLVNYLT PIKHLRKSLK IIYLNSIQEL EIHNMSWPRL IRKLRCYLKE MKTLGKLVFS
RCHHSTSDNE LEGRLVTKFS SVFLGLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL
TYGYLLEEDV KCLSQYPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS LETLILEGCQ
IHYSQLSAIL PGLSRCSQLT TFYFGRNCMS MGALKDLLRH TSGLSKLSLE TYPAPEESLN
SLVRVNWEIF TPLRAELMCT LREVRQPKRI FIGPTPCPSC GSSLSEELEL HLCC
