PRA14_HUMAN
ID PRA14_HUMAN Reviewed; 474 AA.
AC Q5SWL7; A6NFR9;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=PRAME family member 14 {ECO:0000312|HGNC:HGNC:13576};
GN Name=PRAMEF14 {ECO:0000312|HGNC:HGNC:13576};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC243961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS76109.1; -.
DR RefSeq; NP_001019832.2; NM_001024661.2.
DR AlphaFoldDB; Q5SWL7; -.
DR SMR; Q5SWL7; -.
DR STRING; 9606.ENSP00000334410; -.
DR iPTMnet; Q5SWL7; -.
DR PhosphoSitePlus; Q5SWL7; -.
DR BioMuta; PRAMEF14; -.
DR DMDM; 74743941; -.
DR MassIVE; Q5SWL7; -.
DR PaxDb; Q5SWL7; -.
DR PeptideAtlas; Q5SWL7; -.
DR PRIDE; Q5SWL7; -.
DR Antibodypedia; 68128; 5 antibodies from 4 providers.
DR DNASU; 729528; -.
DR Ensembl; ENST00000334600.7; ENSP00000334410.5; ENSG00000204481.8.
DR GeneID; 729528; -.
DR KEGG; hsa:729528; -.
DR MANE-Select; ENST00000334600.7; ENSP00000334410.5; NM_001024661.2; NP_001019832.2.
DR CTD; 729528; -.
DR GeneCards; PRAMEF14; -.
DR HGNC; HGNC:13576; PRAMEF14.
DR neXtProt; NX_Q5SWL7; -.
DR OpenTargets; ENSG00000204481; -.
DR PharmGKB; PA145148171; -.
DR VEuPathDB; HostDB:ENSG00000204481; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; Q5SWL7; -.
DR OMA; ELAINTC; -.
DR OrthoDB; 631249at2759; -.
DR PhylomeDB; Q5SWL7; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; Q5SWL7; -.
DR SignaLink; Q5SWL7; -.
DR BioGRID-ORCS; 729528; 27 hits in 517 CRISPR screens.
DR GenomeRNAi; 729528; -.
DR Pharos; Q5SWL7; Tdark.
DR PRO; PR:Q5SWL7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SWL7; protein.
DR Bgee; ENSG00000204481; Expressed in sural nerve and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..474
FT /note="PRAME family member 14"
FT /id="PRO_0000290166"
FT REPEAT 15..38
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 204..229
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 271..294
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 319..342
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 391..414
FT /note="LRR 5"
FT /evidence="ECO:0000255"
SQ SEQUENCE 474 AA; 55081 MW; D01E07F3F4C8DFC5 CRC64;
MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF MEAFRRRHFQ TLTVMVQAWP
FTCLPLGSLM KTLHLETLKA LLEGLHMLLT QKDRPRRWKL QVLDLRDVDE NFWARWPGAW
ALSCFPETMS KRQTAEDCPR MGEHQPLKVF IDICLKEIPQ DECLRYLFQW VYQRRGLVHL
CCSKLVNYLT PIKHLRKSLK IIYLNSIQQL EIRNMSWPRL IRKLRCYLKE MKNLRKLVFS
RCHHSMSDNE LEGRLVTKFS SVFLRLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL
TYGYLLEEDM KCLSQYPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS LETLILEGCQ
IHYSQLSAIL PGLSHCSQLT TFYFGRNCMS MGALKDLLCH TSGLSKLSLE TYPAPEESLN
SLVRVDWEIF ALLRAELMCT LREVRQPKRI FIGPTPCPSC GSSPSEELEL HLCC
