PRA17_HUMAN
ID PRA17_HUMAN Reviewed; 474 AA.
AC Q5VTA0; B2RUU4;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=PRAME family member 17 {ECO:0000312|HGNC:HGNC:29485};
GN Name=PRAMEF17 {ECO:0000312|HGNC:HGNC:29485};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AL603749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471167; EAW51687.1; -; Genomic_DNA.
DR EMBL; BC144662; AAI44663.1; -; mRNA.
DR EMBL; BC146858; AAI46859.1; -; mRNA.
DR CCDS; CCDS41264.1; -.
DR RefSeq; NP_001093321.1; NM_001099851.3.
DR AlphaFoldDB; Q5VTA0; -.
DR BioGRID; 133764; 11.
DR IntAct; Q5VTA0; 6.
DR STRING; 9606.ENSP00000365266; -.
DR iPTMnet; Q5VTA0; -.
DR PhosphoSitePlus; Q5VTA0; -.
DR BioMuta; PRAMEF17; -.
DR DMDM; 74746907; -.
DR MassIVE; Q5VTA0; -.
DR PaxDb; Q5VTA0; -.
DR PeptideAtlas; Q5VTA0; -.
DR PRIDE; Q5VTA0; -.
DR ProteomicsDB; 65318; -.
DR Antibodypedia; 71974; 65 antibodies from 11 providers.
DR DNASU; 391004; -.
DR Ensembl; ENST00000376098.4; ENSP00000365266.3; ENSG00000204479.4.
DR GeneID; 391004; -.
DR KEGG; hsa:391004; -.
DR MANE-Select; ENST00000376098.4; ENSP00000365266.3; NM_001099851.3; NP_001093321.1.
DR UCSC; uc009vnz.3; human.
DR CTD; 391004; -.
DR GeneCards; PRAMEF17; -.
DR HGNC; HGNC:29485; PRAMEF17.
DR HPA; ENSG00000204479; Not detected.
DR neXtProt; NX_Q5VTA0; -.
DR OpenTargets; ENSG00000204479; -.
DR PharmGKB; PA145148194; -.
DR VEuPathDB; HostDB:ENSG00000204479; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; Q5VTA0; -.
DR OMA; RAFIFCH; -.
DR OrthoDB; 631249at2759; -.
DR PhylomeDB; Q5VTA0; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; Q5VTA0; -.
DR SignaLink; Q5VTA0; -.
DR BioGRID-ORCS; 391004; 109 hits in 628 CRISPR screens.
DR GenomeRNAi; 391004; -.
DR Pharos; Q5VTA0; Tdark.
DR PRO; PR:Q5VTA0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VTA0; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..474
FT /note="PRAME family member 17"
FT /id="PRO_0000290162"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..265
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 266..291
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 292..323
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 324..342
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 348..375
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 376..400
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 474 AA; 54769 MW; 0D21A88813D471C5 CRC64;
MSLQSPSRLL ELAGQSLLRN QFLTIFILDE LPREVFPLMF MEASSMRHFE ALKLMVQAWP
FLRLPLGSLM KTPHLETLQA VLKGLDTLLA QKLRPRRWKL QVLDLRDVDG NFWTIWSGAR
ALSCSPEAMS KRQTVEDYPR TGEHQPLKVF IDLCQKESTL DECLSYLCRW IHYRRGLVHL
CCNKVQNYSM PTSSFRNLLK RVYPDSIQEL EIKRKCSLNK TGKFAPYLSQ MSNLRKLFLA
FGYDDELYVS GQQQFVPDLD CPFLCLYYPQ MLYIRKISNI KEHLEHLLRC LKNPLGTFIF
CHAYLADQDM ECLSQYPSLS QLKELHLIHI LMWTTNLEPL GALLEKVAAT LEILTLKDCQ
IQDSQLRVLL PALSRCSQLT TFYFRGNETS TNALKDLLCH TGGLSKLGLE LYPAPLECLD
NRGHVNWEIL APIRAELMCT LREVRQPKRI FFGPIPCPSC GSWPSEKVDF HLCS
