PRA18_HUMAN
ID PRA18_HUMAN Reviewed; 479 AA.
AC Q5VWM3;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=PRAME family member 18 {ECO:0000312|HGNC:HGNC:30693};
GN Name=PRAMEF18 {ECO:0000312|HGNC:HGNC:30693};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AC244216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001093320.2; NM_001099850.2.
DR AlphaFoldDB; Q5VWM3; -.
DR SMR; Q5VWM3; -.
DR STRING; 9606.ENSP00000485473; -.
DR iPTMnet; Q5VWM3; -.
DR PhosphoSitePlus; Q5VWM3; -.
DR BioMuta; PRAMEF18; -.
DR DMDM; 74747420; -.
DR MassIVE; Q5VWM3; -.
DR PeptideAtlas; Q5VWM3; -.
DR PRIDE; Q5VWM3; -.
DR Antibodypedia; 74329; 56 antibodies from 9 providers.
DR DNASU; 391003; -.
DR Ensembl; ENST00000624297.2; ENSP00000485473.2; ENSG00000279804.2.
DR Ensembl; ENST00000632307.2; ENSP00000488059.2; ENSG00000282212.2.
DR GeneID; 391003; -.
DR KEGG; hsa:391003; -.
DR MANE-Select; ENST00000624297.3; ENSP00000485473.2; NM_001099850.2; NP_001093320.2.
DR CTD; 391003; -.
DR GeneCards; PRAMEF18; -.
DR HGNC; HGNC:30693; PRAMEF18.
DR HPA; ENSG00000279804; Not detected.
DR neXtProt; NX_Q5VWM3; -.
DR OpenTargets; ENSG00000279804; -.
DR PharmGKB; PA145148195; -.
DR VEuPathDB; HostDB:ENSG00000279804; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR InParanoid; Q5VWM3; -.
DR OMA; YSTCILN; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; Q5VWM3; -.
DR BioGRID-ORCS; 391003; 17 hits in 975 CRISPR screens.
DR GenomeRNAi; 391003; -.
DR Pharos; Q5VWM3; Tdark.
DR PRO; PR:Q5VWM3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VWM3; protein.
DR Bgee; ENSG00000279804; Expressed in left adrenal gland cortex and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..479
FT /note="PRAME family member 18"
FT /id="PRO_0000290163"
FT REPEAT 15..38
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..265
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 266..291
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 292..323
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 324..342
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 348..375
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 376..400
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 479 AA; 55334 MW; B65477B0D5E3B8DC CRC64;
MSFQAPRRLL ELAGQSLLRD QALAISVLDE LPRELFPPLF VEAFTSRRCE VLKVMVQAWP
FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRWKL QVLEMRDVDE NFWTIWSGAR
LLSCSPEAMS KRQTVEDCPR TGEKQPLKVF MDVCLKEKFM DEDLSFFSGW VQHRRGSVHL
CCTKVVNYSM SILNFRNILE TVYPDSIQVL EIWNMCWLCM IVEFSRYLSQ MRNLRKLFIS
DGCRYLLSSD SQEQLVAEFS SVLLRLENLQ MLYVRRVCFF RGHLDQLIRC LRSPLETLAL
TYGFLEEEDL KCLPRYPSLS QLKQLNLSHG ALRFIRLEPL RALLEKVAAT LQTLFLVDCG
IGYSKLRVIL PALSRCSNLT TFCFHGNDTS MDALKDLLRH TGRLSNLSLE TYPAPRESLD
NRGRVILELL TPLQAELMRI LREVREPKRI FFGPVSCPCC GTSPTEQLES NFCLWGRPA
