PRA19_HUMAN
ID PRA19_HUMAN Reviewed; 479 AA.
AC Q5SWL8;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=PRAME family member 19 {ECO:0000312|HGNC:HGNC:24908};
GN Name=PRAMEF19 {ECO:0000312|HGNC:HGNC:24908};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AC243961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL603890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001093260.3; NM_001099790.2.
DR AlphaFoldDB; Q5SWL8; -.
DR STRING; 9606.ENSP00000365269; -.
DR iPTMnet; Q5SWL8; -.
DR PhosphoSitePlus; Q5SWL8; -.
DR BioMuta; PRAMEF19; -.
DR DMDM; 74756124; -.
DR MassIVE; Q5SWL8; -.
DR PaxDb; Q5SWL8; -.
DR PeptideAtlas; Q5SWL8; -.
DR PRIDE; Q5SWL8; -.
DR ProteomicsDB; 63978; -.
DR Antibodypedia; 71972; 9 antibodies from 5 providers.
DR DNASU; 645414; -.
DR Ensembl; ENST00000376101.3; ENSP00000365269.2; ENSG00000204480.8.
DR GeneID; 645414; -.
DR KEGG; hsa:645414; -.
DR MANE-Select; ENST00000376101.4; ENSP00000365269.2; NM_001099790.5; NP_001093260.3.
DR UCSC; uc057clc.1; human.
DR CTD; 645414; -.
DR GeneCards; PRAMEF19; -.
DR HGNC; HGNC:24908; PRAMEF19.
DR HPA; ENSG00000204480; Not detected.
DR neXtProt; NX_Q5SWL8; -.
DR OpenTargets; ENSG00000204480; -.
DR VEuPathDB; HostDB:ENSG00000204480; -.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR OMA; EPNRIFF; -.
DR OrthoDB; 631249at2759; -.
DR PathwayCommons; Q5SWL8; -.
DR BioGRID-ORCS; 645414; 5 hits in 157 CRISPR screens.
DR GenomeRNAi; 645414; -.
DR Pharos; Q5SWL8; Tdark.
DR PRO; PR:Q5SWL8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SWL8; protein.
DR Bgee; ENSG00000204480; Expressed in gonad and 2 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..479
FT /note="PRAME family member 19"
FT /id="PRO_0000290167"
FT REPEAT 15..38
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..265
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 266..291
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 292..323
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 324..342
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 348..375
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 376..400
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 479 AA; 55208 MW; B6BE00627F356A4A CRC64;
MSFQAPRRLL ELAGQSLLRD QALAISVLDE LPRELFPRLF VEAFTSRCCE VLKVMVQAWP
FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRWKL QVLEMRDVDE NFWTIWSGAR
PLSCSPEAMS KRQTVEDCPR TGEKQPLKVF MDVCLKEKSV DEDLSFFSGW VQHRRRSVHL
CCTKVVNYSM NILNFRNILE TVYPDSIQVL EIWNMCWPCM VAEVSRYLSQ MKNLRKLFIS
DGCGYLPSFE SQGQLVAEFS SVFLRLEYLQ MLYMRRIRFF EGYLDQLIRC LKSPLETLAL
TYGSLDEEDL KCLPWYPSLS QLKQLNLSHG TLRFIRLEPL RALLEKVAAT LQTLFLVDCG
IGDSKLRVIL PALSRCSNLT TFCFHGNDTS MDGLKDLLRH TGRLSNLSLE TYPAPRESLD
NRGRVISELL TPLQAELMRI LREVREPNRI FFGPVSCPCC GMSPTEQLEF NFCLRGRPA
