ID   ATG13_DANRE             Reviewed;         503 AA.
AC   Q7SYE0;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Autophagy-related protein 13;
GN   Name=atg13; ORFNames=zgc:63526;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Autophagy factor required for autophagosome formation. Target
CC       of the TOR kinase signaling pathway that regulates autophagy through
CC       the control of the phosphorylation status of ATG13 and ULK1, and the
CC       regulation of the ATG13-ULK1-RB1CC1 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q91YI1}. Preautophagosomal structure
CC       {ECO:0000250|UniProtKB:Q91YI1}. Note=Under starvation conditions, is
CC       localized to puncate structures primarily representing the isolation
CC       membrane that sequesters a portion of the cytoplasm resulting in the
CC       formation of an autophagosome. {ECO:0000250|UniProtKB:Q91YI1}.
CC   -!- PTM: Phosphorylated under nutrient-rich conditions; dephosphorylated
CC       during starvation or following treatment with rapamycin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG13 family. Metazoan subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC054904; AAH54904.1; -; mRNA.
DR   RefSeq; NP_956727.1; NM_200433.2.
DR   AlphaFoldDB; Q7SYE0; -.
DR   SMR; Q7SYE0; -.
DR   STRING; 7955.ENSDARP00000052323; -.
DR   PaxDb; Q7SYE0; -.
DR   Ensembl; ENSDART00000052324; ENSDARP00000052323; ENSDARG00000036040.
DR   GeneID; 393405; -.
DR   KEGG; dre:393405; -.
DR   CTD; 9776; -.
DR   ZFIN; ZDB-GENE-040426-1149; atg13.
DR   eggNOG; KOG3874; Eukaryota.
DR   GeneTree; ENSGT00390000007055; -.
DR   HOGENOM; CLU_036365_0_0_1; -.
DR   InParanoid; Q7SYE0; -.
DR   OMA; ICYRIYM; -.
DR   PhylomeDB; Q7SYE0; -.
DR   TreeFam; TF321599; -.
DR   Reactome; R-DRE-1632852; Macroautophagy.
DR   PRO; PR:Q7SYE0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036040; Expressed in spleen and 26 other tissues.
DR   ExpressionAtlas; Q7SYE0; baseline and differential.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0000423; P:mitophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IBA:GO_Central.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR040182; ATG13.
DR   InterPro; IPR018731; Atg13_N.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   PANTHER; PTHR13430; PTHR13430; 1.
DR   Pfam; PF10033; ATG13; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Reference proteome.
FT   CHAIN           1..503
FT                   /note="Autophagy-related protein 13"
FT                   /id="PRO_0000345154"
FT   REGION          300..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  54737 MW;  7C7DE9AC6D1FDE37 CRC64;
     MDSDLSPQDK KDLDKFIKFF ALKTVQVIVQ ARLGEKISTC SSSSPTGSDW FNLAIKDIPE
     VTHEAKKALA GQLPGIGRSM CVEISLKTSE GDSMELETWC LEMNEKCDKD IKVSYTVYNR
     LSLLLKSLLA ITRVTPAYKL SRQQGHDYVI LYRIYFGDVQ LTGLGEGFQT VRVGIVGTPI
     GTITLSCAYR TNLALVSSRQ FERTGPIMGI IIDHFVERPF TNMAHTHPCS YRAPGEDDGG
     TYAGIEDSQE VCTTSFSTSP PSQLYSSRLS YQTPPLGTVD LCHPTACTGA AHPHQMVVPG
     KDGGIPQVPA QPNHGTGAEQ GRIPSCPTGQ PPQLPPPTSC SSEVKTVSPS DVLETTFTRK
     VGAFVNKATT QVTTTGLDLP FAAFAPRSYD MEENDPMVHP PPSPIPSSPL QGSLHSNNSS
     HSGGQPNDDF VMVDFKPAFS KDDLLPMDLG TFYREFQNPP QLASLSIDVS AQSMAEDLDS
     LPEKLAVYEK NIDEFDAFVD TLQ