PRA20_HUMAN
ID PRA20_HUMAN Reviewed; 475 AA.
AC Q5VT98;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=PRAME family member 20 {ECO:0000312|HGNC:HGNC:25224};
GN Name=PRAMEF20 {ECO:0000312|HGNC:HGNC:25224};
GN Synonyms=PRAMEF21 {ECO:0000312|HGNC:HGNC:25224};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC243961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41265.1; -.
DR RefSeq; NP_001093322.2; NM_001099852.2.
DR AlphaFoldDB; Q5VT98; -.
DR BioGRID; 570450; 1.
DR IntAct; Q5VT98; 1.
DR STRING; 9606.ENSP00000346275; -.
DR iPTMnet; Q5VT98; -.
DR PhosphoSitePlus; Q5VT98; -.
DR BioMuta; PRAMEF20; -.
DR DMDM; 74756784; -.
DR MassIVE; Q5VT98; -.
DR PaxDb; Q5VT98; -.
DR PeptideAtlas; Q5VT98; -.
DR PRIDE; Q5VT98; -.
DR ProteomicsDB; 65316; -.
DR Antibodypedia; 73309; 55 antibodies from 10 providers.
DR DNASU; 645425; -.
DR Ensembl; ENST00000602960.1; ENSP00000473584.1; ENSG00000204478.10.
DR GeneID; 645425; -.
DR KEGG; hsa:645425; -.
DR MANE-Select; ENST00000602960.2; ENSP00000473584.1; NM_001099852.2; NP_001093322.2.
DR UCSC; uc009vnv.1; human.
DR CTD; 645425; -.
DR GeneCards; PRAMEF20; -.
DR HGNC; HGNC:25224; PRAMEF20.
DR HPA; ENSG00000204478; Not detected.
DR neXtProt; NX_Q5VT98; -.
DR OpenTargets; ENSG00000204478; -.
DR PharmGKB; PA145148198; -.
DR VEuPathDB; HostDB:ENSG00000204478; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; Q5VT98; -.
DR OMA; CTDYCSR; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; Q5VT98; -.
DR SignaLink; Q5VT98; -.
DR BioGRID-ORCS; 645425; 12 hits in 626 CRISPR screens.
DR GenomeRNAi; 645425; -.
DR Pharos; Q5VT98; Tdark.
DR PRO; PR:Q5VT98; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VT98; protein.
DR Bgee; ENSG00000204478; Expressed in ectocervix.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..475
FT /note="PRAME family member 20"
FT /id="PRO_0000290164"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..265
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 266..291
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 292..323
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 324..342
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 348..375
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 376..400
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 475 AA; 54784 MW; 8CC8E7B0EA52AB99 CRC64;
MSIRTPPRLL ELAGRSLLRD EALAISTLEE LPTELFPPLF MEAFSRRHCE ALKLMVQAWP
FLRLPLGSLM KRPCPETFQA VLDGLDALLT HRVRLRRWKL QVLDLQDVSE NFWMVWSEAM
ARRCLPNAMM NRKPLQDCPR MRGQQPLTVF IDLCLKNRTL DEYFTCLFLW VKQREGLVHL
CCKKLKMLGM LFHNIRNILK TVNLDCIQEV EVNCNWTLPV LAEFTPYLGQ MRNLRKLVLS
DIDSRYISPE QKKEFVTQFT TQFLKLRCLQ KLYMNSVSFL EGHLDQMLSC LKTSLNILAI
TNCVLLESDL KHLSKYPSIG QLKTLDLSGT RLANFSLVPL QVLLEKVAAT LEYLDLDDCG
IVDSQVNAIL PALSRCFELT TFSFRGNPIS TATLENLLCH TIRLNNLCLE LYPAPRESYD
VRGIVCRSRF AQLGAELMGR VRALREPERI LFCTDYCPQC GNRSLYDLEV DRCCC
