ID   PRA22_HUMAN             Reviewed;         481 AA.
AC   A3QJZ6; A6NMM3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 3.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=PRAME family member 22 {ECO:0000312|HGNC:HGNC:34393};
GN   Name=PRAMEF22 {ECO:0000312|HGNC:HGNC:34393};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR589905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001094101.1; NM_001100631.1.
DR   AlphaFoldDB; A3QJZ6; -.
DR   SMR; A3QJZ6; -.
DR   BioGRID; 575922; 1.
DR   IntAct; A3QJZ6; 1.
DR   iPTMnet; A3QJZ6; -.
DR   PhosphoSitePlus; A3QJZ6; -.
DR   BioMuta; HGNC:34393; -.
DR   MassIVE; A3QJZ6; -.
DR   PaxDb; A3QJZ6; -.
DR   PRIDE; A3QJZ6; -.
DR   ProteomicsDB; 588; -.
DR   GeneID; 653606; -.
DR   KEGG; hsa:653606; -.
DR   CTD; 653606; -.
DR   GeneCards; PRAMEF22; -.
DR   HGNC; HGNC:34393; PRAMEF22.
DR   neXtProt; NX_A3QJZ6; -.
DR   PharmGKB; PA162400009; -.
DR   InParanoid; A3QJZ6; -.
DR   OrthoDB; 631249at2759; -.
DR   PhylomeDB; A3QJZ6; -.
DR   TreeFam; TF332708; -.
DR   PathwayCommons; A3QJZ6; -.
DR   BioGRID-ORCS; 653606; 58 hits in 532 CRISPR screens.
DR   GenomeRNAi; 653606; -.
DR   Pharos; A3QJZ6; Tdark.
DR   PRO; PR:A3QJZ6; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A3QJZ6; protein.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR026271; PRAME_family.
DR   PIRSF; PIRSF038286; PRAME; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..481
FT                   /note="PRAME family member 22"
FT                   /id="PRO_0000336087"
FT   REPEAT          99..126
FT                   /note="LRR 1; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          181..205
FT                   /note="LRR 2; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          206..232
FT                   /note="LRR 3; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          233..267
FT                   /note="LRR 4; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          268..293
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          294..325
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          326..344
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          350..377
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          378..402
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ   SEQUENCE   481 AA;  55489 MW;  A19E5460CA5FD766 CRC64;
     MRMSLQAPRR LLELAGQSLL GDQALAISIL DELPRELFPP LFVEAFTSRR CEVLKVMVQA
     WPFPCLPLGS LMKTPDLEIL HYVVDGIDCL LAQKVRPRRW KLQVLELRDV DENFWTIWSG
     ARPLSCSPEA MSKRQTVEDC PRTGEKQPLK VFMDVCLKEK FMDEDLSFFS GWVQHRRGSV
     HLCCTKVVNY SMSILNFRNI LETVYPDSIQ VLEIWNMCWP CMIVEFSRYL SQMRNLRKLF
     ISDGCRYLLS SDSQEQLVAE FSSVLLRLEY LQMLYVRRVC FFRGHLDQLI RCLRSPLETL
     ALTYGFLEKV DLKCLPRYPS LSQLKQLNLS HGALRFIRLE PLRALLEKVA ATLQTLFLVD
     CGIRDSKLRV ILPALSCCSN LTTFCFHGND TSMDGLKDLL RHTGRLSNLS LETYPAPRES
     LDDRGRVISE LLTPLQAELM RILREVREPK RIFFGPVSCP CCGTSPTEQL EFNFCLWGRP
     A