ID   PRA25_HUMAN             Reviewed;         478 AA.
AC   A6NGN4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=PRAME family member 25 {ECO:0000312|HGNC:HGNC:49179};
GN   Name=PRAMEF25 {ECO:0000312|HGNC:HGNC:49179};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR   EMBL; AC245056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS81265.1; -.
DR   RefSeq; NP_001293001.1; NM_001306072.1.
DR   RefSeq; NP_001297063.1; NM_001310134.1.
DR   AlphaFoldDB; A6NGN4; -.
DR   SMR; A6NGN4; -.
DR   STRING; 9606.ENSP00000478309; -.
DR   iPTMnet; A6NGN4; -.
DR   PhosphoSitePlus; A6NGN4; -.
DR   SwissPalm; A6NGN4; -.
DR   BioMuta; PRAMEF25; -.
DR   MassIVE; A6NGN4; -.
DR   PeptideAtlas; A6NGN4; -.
DR   PRIDE; A6NGN4; -.
DR   DNASU; 441873; -.
DR   Ensembl; ENST00000613059.4; ENSP00000481973.1; ENSG00000276299.5.
DR   Ensembl; ENST00000614839.4; ENSP00000481683.1; ENSG00000229571.7.
DR   Ensembl; ENST00000619661.2; ENSP00000478309.2; ENSG00000229571.7.
DR   Ensembl; ENST00000632559.1; ENSP00000488003.1; ENSG00000282566.2.
DR   Ensembl; ENST00000634012.1; ENSP00000488324.1; ENSG00000282566.2.
DR   Ensembl; ENST00000635813.1; ENSP00000490751.1; ENSG00000283348.2.
DR   Ensembl; ENST00000636290.1; ENSP00000490779.1; ENSG00000283348.2.
DR   GeneID; 441873; -.
DR   GeneID; 645359; -.
DR   KEGG; hsa:441873; -.
DR   KEGG; hsa:645359; -.
DR   MANE-Select; ENST00000619661.3; ENSP00000478309.2; NM_001310134.3; NP_001297063.1.
DR   MANE-Select; ENST00000624207.2; ENSP00000485656.1; NM_001306072.3; NP_001293001.1.
DR   UCSC; uc057cks.1; human.
DR   CTD; 441873; -.
DR   CTD; 645359; -.
DR   GeneCards; PRAMEF25; -.
DR   HGNC; HGNC:49179; PRAMEF25.
DR   HPA; ENSG00000229571; Not detected.
DR   neXtProt; NX_A6NGN4; -.
DR   OpenTargets; ENSG00000229571; -.
DR   OpenTargets; ENSG00000280267; -.
DR   VEuPathDB; HostDB:ENSG00000229571; -.
DR   eggNOG; ENOG502QWSJ; Eukaryota.
DR   GeneTree; ENSGT01030000234531; -.
DR   HOGENOM; CLU_039635_2_1_1; -.
DR   InParanoid; A6NGN4; -.
DR   OMA; GLDDCGI; -.
DR   OrthoDB; 631249at2759; -.
DR   PathwayCommons; A6NGN4; -.
DR   BioGRID-ORCS; 441873; 1 hit in 23 CRISPR screens.
DR   BioGRID-ORCS; 645359; 3 hits in 52 CRISPR screens.
DR   ChiTaRS; PRAMEF25; human.
DR   Pharos; A6NGN4; Tdark.
DR   PRO; PR:A6NGN4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; A6NGN4; protein.
DR   Bgee; ENSG00000229571; Expressed in monocyte and 11 other tissues.
DR   Genevisible; A6NGN4; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR026271; PRAME_family.
DR   PIRSF; PIRSF038286; PRAME; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..478
FT                   /note="PRAME family member 25"
FT                   /id="PRO_0000348940"
FT   REPEAT          99..126
FT                   /note="LRR 1; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          181..205
FT                   /note="LRR 2; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          206..232
FT                   /note="LRR 3; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          233..268
FT                   /note="LRR 4; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          269..294
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          295..326
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          327..347
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          351..378
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          379..403
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ   SEQUENCE   478 AA;  55354 MW;  ED86A6A6A0FD601C CRC64;
     MKMSIRTPPR LLELAGRSVL RDQALAMSTL EELPTELFPP LFMEAFSRRR CEALKLMVQA
     WPFRRLPLRP LIKMPCLETF QAVLNGLDAL LTHGVRPRRW KLQVLDLQDV CENFWMVWSE
     AMARGCFLNA KRNKKPVQDC PRMRGRQPLT VFVELWLKNR TLDEHLTCLL LWVKQRKDLL
     HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV
     LSHMDVSRYV SPEQKKEIVT QFTTQFLKLH CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
     LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD
     DCGIIDSQVN AILPALSRCF ELNTFSFCGN PISMATLENL LSHTIILKNL CLELYPAPRE
     SYGADGTLCW SRFTQIRAEL MKRVRDLRHP KRILFGTDYC PDCGNRSFYD LEADQYCC