ATG13_DEBHA
ID ATG13_DEBHA Reviewed; 837 AA.
AC Q6BQ20; B5RTX9;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Autophagy-related protein 13;
GN Name=ATG13; OrderedLocusNames=DEHA2E09020g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Activates the ATG1 kinase in a nutritional condition
CC dependent manner through the TOR pathway, leading to autophagy. Also
CC involved in cytoplasm to vacuole transport (Cvt) and more specifically
CC in Cvt vesicle formation. Seems to play a role in the switching
CC machinery regulating the conversion between the Cvt pathway and
CC autophagy. Finally, ATG13 is also required for glycogen storage during
CC stationary phase (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ATG1 to form the ATG1-ATG13 kinase complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06628}.
CC Preautophagosomal structure {ECO:0000250|UniProtKB:Q06628}.
CC -!- SIMILARITY: Belongs to the ATG13 family. Fungi subfamily.
CC {ECO:0000305}.
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DR EMBL; CR382137; CAR65791.1; -; Genomic_DNA.
DR RefSeq; XP_002770448.1; XM_002770402.1.
DR AlphaFoldDB; Q6BQ20; -.
DR SMR; Q6BQ20; -.
DR STRING; 4959.XP_002770448.1; -.
DR EnsemblFungi; CAR65791; CAR65791; DEHA2E09020g.
DR GeneID; 8998709; -.
DR KEGG; dha:DEHA2E09020g; -.
DR VEuPathDB; FungiDB:DEHA2E09020g; -.
DR eggNOG; KOG4573; Eukaryota.
DR HOGENOM; CLU_366802_0_0_1; -.
DR InParanoid; Q6BQ20; -.
DR OMA; MHQHPRS; -.
DR OrthoDB; 1519629at2759; -.
DR Proteomes; UP000000599; Chromosome E.
DR GO; GO:1990316; C:Atg1/ULK1 kinase complex; IEA:InterPro.
DR GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR040182; ATG13.
DR InterPro; IPR018731; Atg13_N.
DR InterPro; IPR036570; HORMA_dom_sf.
DR PANTHER; PTHR13430; PTHR13430; 1.
DR Pfam; PF10033; ATG13; 1.
PE 3: Inferred from homology;
KW Autophagy; Cytoplasm; Protein transport; Reference proteome; Transport.
FT CHAIN 1..837
FT /note="Autophagy-related protein 13"
FT /id="PRO_0000157968"
FT REGION 302..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 92307 MW; AE7E6361679BAE30 CRC64;
MVSPGQNDLS SDKSQIDPFV KKQNAKLTQV IQNFFSKSVQ IVLQSRIQSE SHNKEEQLKV
GGDVGGHNVS SKINKWFNLH MYNDNLPKEE LKLWKNINDV SQMPPMIIEV YLDLRQLTAI
QTVILRDDNG NPWTVAKGGS KKHEVVLERW LIEFDANTVS GTIVDELPLI YKQAIILFRS
LYGYTRLMPT FKLKKNLNKS NLNIGCKILD GKQPISSKGR IGLSKSIIPH QMLTTESHMS
HKHFLPIQTT LGTLKISIAY RNHHEFSIHD NEELLSTHFV NIDDNDKDSE ITPVEIEFKE
ELKIDRDSTT NEKVNEPEDD ESHHADVESS QEHLQSEEPD ESFEQDAKHI SGSRKKFSIS
NNASMSLSPC SSGPQTVTED SPSHNKPSAN TTPIVSQRPT INPFKVGSIS TSPPATTNFG
GSSLERKVSI TSNKSASNAS LAAMLRNPRS STSSTNTTAN IPIANNNSNN QYNSTFPRSV
SSSHGSNLAH DNDNLLGFSN PDNTSNTPRF SSSFGSRASR RFSNTSGRQS SLPSGNMNDT
SLLATSAGSA SSDAPMSGLY IDDDIGDFVR MIDSKSDLRF SGYNSNNDSK ISYNQGSNSQ
IDALNKFQML KNQHQQLSDS VSASLILHHN QLSGSRPSSR KSSHSIHSPP PSLPSGSYDN
SHLPSINSKL RENSSTSGND DNLARDSGTP SSRKNSFDYS TNSNTTFLKS PITNKLVSSP
VTSTTPIHSC LHKTNNESGV ISGLATTPSI YNDRRQIHYE SVFDDDDDDY ANNTADNRDQ
DDSLKLYLTN KLANAPKSNT NSRSLKSSTN PPNIGEDDDD DDDDLLFTMS DMNLAKH
