PRA27_HUMAN
ID PRA27_HUMAN Reviewed; 478 AA.
AC A3QJZ7;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 29-OCT-2014, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=PRAME family member 27 {ECO:0000312|HGNC:HGNC:51234};
GN Name=PRAMEF27 {ECO:0000312|HGNC:HGNC:51234};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC245056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS72704.1; -.
DR RefSeq; NP_001287820.1; NM_001300891.1.
DR AlphaFoldDB; A3QJZ7; -.
DR iPTMnet; A3QJZ7; -.
DR PhosphoSitePlus; A3QJZ7; -.
DR SwissPalm; A3QJZ7; -.
DR BioMuta; PRAMEF27; -.
DR MassIVE; A3QJZ7; -.
DR PeptideAtlas; A3QJZ7; -.
DR PRIDE; A3QJZ7; -.
DR DNASU; 101929983; -.
DR Ensembl; ENST00000436041.6; ENSP00000393136.2; ENSG00000274764.6.
DR Ensembl; ENST00000631964.1; ENSP00000488085.1; ENSG00000282437.2.
DR Ensembl; ENST00000636332.1; ENSP00000490306.1; ENSG00000283425.1.
DR GeneID; 101929983; -.
DR KEGG; hsa:101929983; -.
DR MANE-Select; ENST00000436041.6; ENSP00000393136.2; NM_001300891.2; NP_001287820.1.
DR UCSC; uc057ckn.1; human.
DR CTD; 101929983; -.
DR GeneCards; PRAMEF27; -.
DR HGNC; HGNC:51234; PRAMEF27.
DR HPA; ENSG00000274764; Not detected.
DR neXtProt; NX_A3QJZ7; -.
DR VEuPathDB; HostDB:ENSG00000274764; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; A3QJZ7; -.
DR OMA; CEINDSH; -.
DR OrthoDB; 631249at2759; -.
DR BioGRID-ORCS; 101929983; 0 hits in 74 CRISPR screens.
DR GenomeRNAi; 101929983; -.
DR Pharos; A3QJZ7; Tdark.
DR PRO; PR:A3QJZ7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A3QJZ7; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..478
FT /note="PRAME family member 27"
FT /id="PRO_0000435289"
FT REPEAT 17..40
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 99..126
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 181..205
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 206..232
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 233..268
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 269..294
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 295..326
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 327..348
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 351..378
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 379..403
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 478 AA; 55206 MW; 9FE489BE24051B58 CRC64;
MKMSIRTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRC CEALKLMVQA
WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LTQGVCPRRW KLQVLDLQDV CENFWMVWSE
AMARGSFLNA KRNKTPVQDC PRMRGQQPLT VFVELWLKNR TLDEYLTYLL LWVKQRKDLL
HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV
LSHMDVSRYV SPEQKKEIVT QFTTQFLKLH CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD
DCGIIDSQVN AILPALSRCF ELNAFSFCGN PISMATLENL LSHTIILKNL CVEVYPAPRE
SYGADGTLCW NRFAQIRAEL MNRVRDLRHP KRIFFCIDNC PDCGNRSFYD LEADQYCC
