PRA33_HUMAN
ID PRA33_HUMAN Reviewed; 474 AA.
AC A0A0G2JMD5;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=PRAME family member 33 {ECO:0000305};
GN Name=PRAMEF33 {ECO:0000312|HGNC:HGNC:49193};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AC244216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS85928.1; -.
DR RefSeq; NP_001278310.1; NM_001291381.1.
DR AlphaFoldDB; A0A0G2JMD5; -.
DR BioMuta; PRAMEF33; -.
DR MassIVE; A0A0G2JMD5; -.
DR DNASU; 645382; -.
DR Ensembl; ENST00000437300.2; ENSP00000492439.1; ENSG00000237700.2.
DR Ensembl; ENST00000632108.2; ENSP00000491658.1; ENSG00000282125.2.
DR Ensembl; ENST00000636272.2; ENSP00000490148.2; ENSG00000283488.2.
DR GeneID; 645382; -.
DR KEGG; hsa:645382; -.
DR MANE-Select; ENST00000437300.2; ENSP00000492439.1; NM_001291381.1; NP_001278310.1.
DR CTD; 645382; -.
DR GeneCards; PRAMEF33; -.
DR HGNC; HGNC:49193; PRAMEF33.
DR HPA; ENSG00000237700; Tissue enriched (liver).
DR neXtProt; NX_A0A0G2JMD5; -.
DR VEuPathDB; HostDB:ENSG00000237700; -.
DR GeneTree; ENSGT01030000234531; -.
DR OrthoDB; 631249at2759; -.
DR BioGRID-ORCS; 645382; 3 hits in 73 CRISPR screens.
DR GenomeRNAi; 645382; -.
DR Pharos; A0A0G2JMD5; Tdark.
DR PRO; PR:A0A0G2JMD5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A0A0G2JMD5; protein.
DR Bgee; ENSG00000237700; Expressed in liver and 1 other tissue.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..474
FT /note="PRAME family member 33"
FT /id="PRO_0000440971"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..262
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 263..291
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 292..323
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 324..347
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 348..375
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 376..400
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 474 AA; 55092 MW; C5ED9A3D75357C4A CRC64;
MSLQAPSRLL ELAGQSLLRN QFLTIFTLDE LPREVFPLMF MEAFSMRRFE ALKLMVQAWP
FLRLPLGSLM KTPHLETLQA VLRGLDTLVA QKVRPRRWKL QVLDLQDVDE NFWTIWSGAR
VLSCSPEAMS KRQTVEDCPR MGEHQPLKVF IDLCLKESTL DECLSYLFGW IHYRRGLVHL
CCSKVQNYSM PTSSFRNLLE RIYPDSIQEL EVWKKCSLNK TGKFAPYLSQ MSNLRELFLA
FGYERELYVS VQWPCIPDLD SPFLCLYYPQ MLYIKKISNI KEHLEHLLRY LKNPLGAFIF
SDAYLADRDM ECLSQYPSLS QLKELRLIHI LMWTTNLQPL GALLEKVAAT LKTLVLKDCR
IQDPQLRVLL PALSHCSQLT TFNFHGNETS MNALKDLLRH TRGLSKLGLE LYPAPLESLD
YKGHVNWEIL TPIRAELMRT LREVRQPKRI FFGPVPCPTC GSWPSEKVDF HLCS
