PRAC1_HUMAN
ID PRAC1_HUMAN Reviewed; 57 AA.
AC Q96KF2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Small nuclear protein PRAC1;
DE AltName: Full=Prostate cancer susceptibility candidate protein 1;
DE AltName: Full=Prostate, rectum and colon expressed gene protein;
GN Name=PRAC1; Synonyms=C17orf92, PRAC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Prostate;
RX PubMed=11340635; DOI=10.1002/pros.1055;
RA Liu X.F., Olsson P., Wolfgang C.D., Bera T.K., Duray P., Lee B., Pastan I.;
RT "PRAC: a novel small nuclear protein that is specifically expressed in
RT human prostate and colon.";
RL Prostate 47:125-131(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11340635}.
CC -!- TISSUE SPECIFICITY: Highly expressed in prostate, rectum, and distal
CC colon, and weakly expressed in bladder. Expressed in prostate cancer
CC cell lines. {ECO:0000269|PubMed:11340635}.
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DR EMBL; AF331165; AAK38837.1; -; mRNA.
DR EMBL; AC091179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94717.1; -; Genomic_DNA.
DR EMBL; BC030950; AAH30950.1; -; mRNA.
DR CCDS; CCDS11535.1; -.
DR RefSeq; NP_115767.1; NM_032391.2.
DR AlphaFoldDB; Q96KF2; -.
DR STRING; 9606.ENSP00000290294; -.
DR iPTMnet; Q96KF2; -.
DR PhosphoSitePlus; Q96KF2; -.
DR BioMuta; PRAC1; -.
DR PaxDb; Q96KF2; -.
DR PRIDE; Q96KF2; -.
DR ProteomicsDB; 77065; -.
DR Antibodypedia; 45201; 88 antibodies from 22 providers.
DR DNASU; 84366; -.
DR Ensembl; ENST00000290294.5; ENSP00000290294.3; ENSG00000159182.5.
DR GeneID; 84366; -.
DR KEGG; hsa:84366; -.
DR MANE-Select; ENST00000290294.5; ENSP00000290294.3; NM_032391.3; NP_115767.1.
DR UCSC; uc002iny.4; human.
DR CTD; 84366; -.
DR DisGeNET; 84366; -.
DR GeneCards; PRAC1; -.
DR HGNC; HGNC:30591; PRAC1.
DR HPA; ENSG00000159182; Group enriched (intestine, prostate).
DR MIM; 609819; gene.
DR neXtProt; NX_Q96KF2; -.
DR OpenTargets; ENSG00000159182; -.
DR PharmGKB; PA164725009; -.
DR VEuPathDB; HostDB:ENSG00000159182; -.
DR eggNOG; ENOG502TEAX; Eukaryota.
DR GeneTree; ENSGT00940000165611; -.
DR HOGENOM; CLU_2995884_0_0_1; -.
DR InParanoid; Q96KF2; -.
DR OMA; RDGSACN; -.
DR PhylomeDB; Q96KF2; -.
DR TreeFam; TF341666; -.
DR PathwayCommons; Q96KF2; -.
DR BioGRID-ORCS; 84366; 147 hits in 1046 CRISPR screens.
DR ChiTaRS; PRAC1; human.
DR GenomeRNAi; 84366; -.
DR Pharos; Q96KF2; Tbio.
DR PRO; PR:Q96KF2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96KF2; protein.
DR Bgee; ENSG00000159182; Expressed in rectum and 64 other tissues.
DR Genevisible; Q96KF2; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..57
FT /note="Small nuclear protein PRAC1"
FT /id="PRO_0000312417"
FT REGION 38..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 4
FT /note="A -> V (in dbSNP:rs34734055)"
FT /id="VAR_051285"
SQ SEQUENCE 57 AA; 5959 MW; A460DC3FDAB1A49D CRC64;
MLCAHFSDQG PAHLTTSKSA FLSNKKTSTL KHLLGETRSD GSACNSGISG GRGRKIP
