ID   PRAC2_HUMAN             Reviewed;          90 AA.
AC   D3DTV9;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Putative protein PRAC2 {ECO:0000305};
DE   AltName: Full=Prostate, rectum and colon expressed gene protein 2 {ECO:0000303|PubMed:12746837};
GN   Name=PRAC2 {ECO:0000312|HGNC:HGNC:30143};
GN   Synonyms=C17orf93 {ECO:0000312|HGNC:HGNC:30143},
GN   HOXB-AS5 {ECO:0000312|HGNC:HGNC:30143},
GN   HOXB13-AS1 {ECO:0000312|HGNC:HGNC:30143},
GN   NCRNA00253 {ECO:0000312|HGNC:HGNC:30143};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=12746837; DOI=10.1002/pros.10185;
RA   Olsson P., Motegi A., Bera T.K., Lee B., Pastan I.;
RT   "PRAC2: a new gene expressed in human prostate and prostate cancer.";
RL   Prostate 56:123-130(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12746837}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in prostate and testis. Also
CC       detected in placenta, muscle, colon, peripheral blood leukocytes and
CC       skin. {ECO:0000269|PubMed:12746837}.
CC   -!- CAUTION: Product of a dubious CDS prediction. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC091179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471109; EAW94715.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94716.1; -; Genomic_DNA.
DR   CCDS; CCDS74100.1; -.
DR   RefSeq; NP_001269204.1; NM_001282275.1.
DR   RefSeq; XP_006721928.1; XM_006721865.3.
DR   RefSeq; XP_011523049.1; XM_011524747.2.
DR   RefSeq; XP_011523050.1; XM_011524748.1.
DR   AlphaFoldDB; D3DTV9; -.
DR   STRING; 9606.ENSP00000484945; -.
DR   BioMuta; PRAC2; -.
DR   PRIDE; D3DTV9; -.
DR   DNASU; 360205; -.
DR   Ensembl; ENST00000422730.4; ENSP00000481367.1; ENSG00000229637.4.
DR   GeneID; 360205; -.
DR   KEGG; hsa:360205; -.
DR   MANE-Select; ENST00000422730.4; ENSP00000481367.1; NM_001282275.2; NP_001269204.1.
DR   UCSC; uc002inz.3; human.
DR   CTD; 360205; -.
DR   DisGeNET; 360205; -.
DR   GeneCards; PRAC2; -.
DR   HGNC; HGNC:30143; PRAC2.
DR   HPA; ENSG00000229637; Group enriched (intestine, prostate).
DR   MIM; 610787; gene.
DR   neXtProt; NX_D3DTV9; -.
DR   OpenTargets; ENSG00000229637; -.
DR   VEuPathDB; HostDB:ENSG00000229637; -.
DR   eggNOG; ENOG502TDNB; Eukaryota.
DR   GeneTree; ENSGT00860000135909; -.
DR   HOGENOM; CLU_2440232_0_0_1; -.
DR   OrthoDB; 1422494at2759; -.
DR   PathwayCommons; D3DTV9; -.
DR   BioGRID-ORCS; 360205; 4 hits in 121 CRISPR screens.
DR   ChiTaRS; PRAC2; human.
DR   GenomeRNAi; 360205; -.
DR   Pharos; D3DTV9; Tdark.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; D3DTV9; protein.
DR   Bgee; ENSG00000229637; Expressed in rectum and 20 other tissues.
DR   ExpressionAtlas; D3DTV9; baseline and differential.
DR   Genevisible; D3DTV9; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   5: Uncertain;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..90
FT                   /note="Putative protein PRAC2"
FT                   /id="PRO_0000430950"
SQ   SEQUENCE   90 AA;  10428 MW;  FCB8A19C8047D814 CRC64;
     MDRRRMALRP GSRRPTAFFF HSRWLVPNLL AFFLGLSGAG PIHLPMPWPN GRRHRVLDPH
     TQLSTHEAPG RWKPVAPRTM KACPQVLLEW