ID   PRAF2_BOVIN             Reviewed;         178 AA.
AC   Q2KHX3;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=PRA1 family protein 2;
GN   Name=PRAF2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Kidney;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in ER/Golgi transport and vesicular traffic.
CC       Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CCR5 and GDE1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRA1 family. {ECO:0000305}.
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DR   EMBL; BC112850; AAI12851.1; -; mRNA.
DR   RefSeq; NP_001039474.1; NM_001046009.2.
DR   AlphaFoldDB; Q2KHX3; -.
DR   STRING; 9913.ENSBTAP00000003318; -.
DR   PaxDb; Q2KHX3; -.
DR   PRIDE; Q2KHX3; -.
DR   Ensembl; ENSBTAT00000003318; ENSBTAP00000003318; ENSBTAG00000002562.
DR   GeneID; 508703; -.
DR   KEGG; bta:508703; -.
DR   CTD; 11230; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002562; -.
DR   VGNC; VGNC:33283; PRAF2.
DR   eggNOG; KOG4050; Eukaryota.
DR   GeneTree; ENSGT00390000008631; -.
DR   HOGENOM; CLU_097683_0_0_1; -.
DR   InParanoid; Q2KHX3; -.
DR   OMA; GDPQRWC; -.
DR   OrthoDB; 1288023at2759; -.
DR   TreeFam; TF105479; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000002562; Expressed in trachea and 102 other tissues.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004895; Prenylated_rab_accept_PRA1.
DR   PANTHER; PTHR12859; PTHR12859; 1.
DR   Pfam; PF03208; PRA1; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..178
FT                   /note="PRA1 family protein 2"
FT                   /id="PRO_0000234485"
FT   TOPO_DOM        1..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..178
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   178 AA;  19174 MW;  F9B896F49648A463 CRC64;
     MSEVRLPPLR ALDDFVLGSA RLVAPDPCDP QRWCHRVINN LLYYQTNYLI CFGLGLALAG
     YVRPLHTLLS ALVVAVALGM LVCAAENRAA VRRCRRSHPA ACLAAVLAVG FLVLWAAGGA
     GTFLLSIAGP VLLILVHASL RLRNLKNKIE NKIESIGLKR TPMGLLLEAL GQEQEAGS