ID   PRAF2_MACFA             Reviewed;         178 AA.
AC   Q4R4I9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=PRA1 family protein 2;
GN   Name=PRAF2; ORFNames=QtrA-11986;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in ER/Golgi transport and vesicular traffic.
CC       Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CCR5 and GDE1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRA1 family. {ECO:0000305}.
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DR   EMBL; AB169905; BAE01986.1; -; mRNA.
DR   RefSeq; NP_001270208.1; NM_001283279.1.
DR   AlphaFoldDB; Q4R4I9; -.
DR   STRING; 9541.XP_005593587.1; -.
DR   GeneID; 101926174; -.
DR   CTD; 11230; -.
DR   VEuPathDB; HostDB:ENSMFAG00000032970; -.
DR   eggNOG; KOG4050; Eukaryota.
DR   OrthoDB; 1288023at2759; -.
DR   Proteomes; UP000233100; Chromosome X.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004895; Prenylated_rab_accept_PRA1.
DR   PANTHER; PTHR12859; PTHR12859; 1.
DR   Pfam; PF03208; PRA1; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..178
FT                   /note="PRA1 family protein 2"
FT                   /id="PRO_0000234486"
FT   TOPO_DOM        1..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..178
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   178 AA;  19284 MW;  02E490D6994EA822 CRC64;
     MSEVRLPPLR ALDDFVLGSA RLAAPDPCDP QRWCHRVINN LLYYQTNYLL CFGIGLALAG
     YVRPLHTLLS ALVVAVALGM LVWAAETRAA VRRCRRSHPA ACLAAVLAVG LLVLWVVGGA
     CTFLLSIAGP VLLILVHASL RLRNLKNKIE NKIESIGLKR TPMGLLLEAL GQEQEAGS