ID   PRAFA_DICDI             Reviewed;         235 AA.
AC   Q54XK1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=PRA1 family protein 1;
GN   Name=prafA; ORFNames=DDB_G0278887;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May act as a general Rab protein regulator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PRA1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000024; EAL68045.1; -; Genomic_DNA.
DR   RefSeq; XP_647802.1; XM_642710.1.
DR   AlphaFoldDB; Q54XK1; -.
DR   STRING; 44689.DDB0304559; -.
DR   PaxDb; Q54XK1; -.
DR   EnsemblProtists; EAL68045; EAL68045; DDB_G0278887.
DR   GeneID; 8621762; -.
DR   KEGG; ddi:DDB_G0278887; -.
DR   dictyBase; DDB_G0278887; prafA.
DR   eggNOG; KOG3142; Eukaryota.
DR   HOGENOM; CLU_1182018_0_0_1; -.
DR   InParanoid; Q54XK1; -.
DR   OMA; VVYFQSN; -.
DR   PhylomeDB; Q54XK1; -.
DR   PRO; PR:Q54XK1; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004895; Prenylated_rab_accept_PRA1.
DR   PANTHER; PTHR19317; PTHR19317; 1.
DR   Pfam; PF03208; PRA1; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..235
FT                   /note="PRA1 family protein 1"
FT                   /id="PRO_0000340240"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   235 AA;  25930 MW;  739A39057FB0A6B9 CRC64;
     MESNSNSNET MYGNPNINMG FVDSGNSNIG NNTGSMSPPP QQQQQPQQAS STPAGSVGIG
     GLSFSLGANG ISLEPSSISH RVNAITSKIK EFKQERMETT RDWRSFVGSR QQYGLPNIKD
     TTSRIKENVV YFQSNYLILF LCFSVFFIIT NPFYLLLLGV LLFISVYLHN STTLTDIQRK
     IAYGIQAFLS IYFLLYAGSS IFWLVGATCC ITLLHASFHS PNSTDETNIK FGDGV