PRAFB_DICDI
ID PRAFB_DICDI Reviewed; 158 AA.
AC Q54NS7; C7G033;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=PRA1 family protein 2;
GN Name=prafB; ORFNames=DDB_G0285007;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May act as a general Rab protein regulator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PRA1 family. {ECO:0000305}.
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DR EMBL; AAFI02000073; EEU04086.1; -; Genomic_DNA.
DR RefSeq; XP_002649138.1; XM_002649092.1.
DR AlphaFoldDB; Q54NS7; -.
DR TCDB; 9.A.49.1.10; the prenylated rab acceptor protein 1 (pra1) family.
DR PaxDb; Q54NS7; -.
DR EnsemblProtists; EEU04086; EEU04086; DDB_G0285007.
DR GeneID; 8624907; -.
DR KEGG; ddi:DDB_G0285007; -.
DR dictyBase; DDB_G0285007; prafB.
DR eggNOG; ENOG502RHMD; Eukaryota.
DR HOGENOM; CLU_1672526_0_0_1; -.
DR InParanoid; Q54NS7; -.
DR OMA; ITRMEDN; -.
DR PhylomeDB; Q54NS7; -.
DR PRO; PR:Q54NS7; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004895; Prenylated_rab_accept_PRA1.
DR PANTHER; PTHR19317; PTHR19317; 1.
DR Pfam; PF03208; PRA1; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..158
FT /note="PRA1 family protein 2"
FT /id="PRO_0000340241"
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 158 AA; 17605 MW; 92FEC73608C63853 CRC64;
MSSSSSIKLQ PWNDFIEWGR YSIPGSQNAI TRMEDNLNFY SGNYIAIVAV VLLITLFTNM
NLLVAILLLG AIGYYLFFVQ KGDKNIGFAV LTPMIQMVIL GVVSVIVIYK LSGLTLFYTT
LVSLLFVLAH SALKMRNLKN KASNFVSGIK NDLKNELK
