PRAM4_HUMAN
ID PRAM4_HUMAN Reviewed; 478 AA.
AC O60810; Q5LJB5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 5.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=PRAME family member 4 {ECO:0000312|HGNC:HGNC:31971};
GN Name=PRAMEF4 {ECO:0000312|HGNC:HGNC:31971};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-477.
RA Rhodes S.;
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41253.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC245034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL022101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL049681; CAB41253.1; ALT_INIT; mRNA.
DR CCDS; CCDS30592.1; -.
DR RefSeq; NP_001009611.2; NM_001009611.4.
DR AlphaFoldDB; O60810; -.
DR IntAct; O60810; 2.
DR MINT; O60810; -.
DR STRING; 9606.ENSP00000235349; -.
DR iPTMnet; O60810; -.
DR PhosphoSitePlus; O60810; -.
DR SwissPalm; O60810; -.
DR BioMuta; PRAMEF4; -.
DR MassIVE; O60810; -.
DR PaxDb; O60810; -.
DR PeptideAtlas; O60810; -.
DR PRIDE; O60810; -.
DR ProteomicsDB; 49603; -.
DR DNASU; 400735; -.
DR Ensembl; ENST00000235349.6; ENSP00000235349.5; ENSG00000243073.4.
DR Ensembl; ENST00000632563.2; ENSP00000488161.1; ENSG00000282584.2.
DR GeneID; 400735; -.
DR KEGG; hsa:400735; -.
DR MANE-Select; ENST00000235349.6; ENSP00000235349.5; NM_001009611.4; NP_001009611.2.
DR UCSC; uc001aun.3; human.
DR CTD; 400735; -.
DR GeneCards; PRAMEF4; -.
DR HGNC; HGNC:31971; PRAMEF4.
DR HPA; ENSG00000243073; Not detected.
DR neXtProt; NX_O60810; -.
DR OpenTargets; ENSG00000243073; -.
DR PharmGKB; PA142671141; -.
DR VEuPathDB; HostDB:ENSG00000243073; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; O60810; -.
DR OMA; KCEMADS; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; O60810; -.
DR BioGRID-ORCS; 400735; 10 hits in 979 CRISPR screens.
DR ChiTaRS; PRAMEF4; human.
DR GenomeRNAi; 400735; -.
DR Pharos; O60810; Tdark.
DR PRO; PR:O60810; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O60810; protein.
DR Bgee; ENSG00000243073; Expressed in blood.
DR Genevisible; O60810; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..478
FT /note="PRAME family member 4"
FT /id="PRO_0000156978"
FT REPEAT 99..126
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 181..205
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 206..232
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 233..268
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 269..294
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 295..326
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 327..347
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 351..378
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 379..403
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT VARIANT 85
FT /note="D -> E (in dbSNP:rs4625290)"
FT /id="VAR_053607"
FT CONFLICT 144
FT /note="K -> R (in Ref. 2; CAB41253)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 478 AA; 55439 MW; 87B63A5E00C24702 CRC64;
MKMSIWTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRR CEALKLMVQS
WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LNLGVRPRRW KLQVLDLQDV CENFWMVWSE
AMAHGCFLNA KRNKKPVEDC PRMKGRQPLT VFVELWLKNR TLDEYLTCLL LWVKQRKDLL
HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLI
LSHMDVSRYV SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKF
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD
DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL LSHTIILKNL CVELYPAPRE
SYGADGTLCW SRFAQIRAEL MNRVRDLRHP KRILFCTDYC PDCGNRSFYD LEADQYCC
