PRAM5_HUMAN
ID PRAM5_HUMAN Reviewed; 476 AA.
AC Q5TYX0; A0A087WWD0; A2BDD6; A4FU31; A6NMV5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2015, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=PRAME family member 5 {ECO:0000312|HGNC:HGNC:27995};
GN Name=PRAMEF5 {ECO:0000312|HGNC:HGNC:27995};
GN Synonyms=PRAMEF23 {ECO:0000312|HGNC:HGNC:27995},
GN PRAMEF5L {ECO:0000312|HGNC:HGNC:27995};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AC244216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101344; AAI01345.1; -; mRNA.
DR EMBL; BC130274; AAI30275.1; -; mRNA.
DR EMBL; BC130276; AAI30277.1; -; mRNA.
DR CCDS; CCDS72708.1; -.
DR RefSeq; NP_001013425.2; NM_001013407.2.
DR AlphaFoldDB; Q5TYX0; -.
DR IntAct; Q5TYX0; 2.
DR STRING; 9606.ENSP00000480122; -.
DR iPTMnet; Q5TYX0; -.
DR PhosphoSitePlus; Q5TYX0; -.
DR SwissPalm; Q5TYX0; -.
DR BioMuta; PRAMEF5; -.
DR DMDM; 74756668; -.
DR MassIVE; Q5TYX0; -.
DR PaxDb; Q5TYX0; -.
DR PeptideAtlas; Q5TYX0; -.
DR PRIDE; Q5TYX0; -.
DR ProteomicsDB; 1564; -.
DR Antibodypedia; 77555; 26 antibodies from 5 providers.
DR DNASU; 343068; -.
DR Ensembl; ENST00000618079.4; ENSP00000478534.2; ENSG00000283150.1.
DR Ensembl; ENST00000621481.4; ENSP00000482418.1; ENSG00000276420.5.
DR Ensembl; ENST00000622421.2; ENSP00000480122.1; ENSG00000270601.4.
DR Ensembl; ENST00000633074.1; ENSP00000488527.1; ENSG00000282424.1.
DR GeneID; 343068; -.
DR KEGG; hsa:343068; -.
DR MANE-Select; ENST00000622421.3; ENSP00000480122.1; NM_001013407.5; NP_001013425.2.
DR UCSC; uc001auu.1; human.
DR CTD; 343068; -.
DR GeneCards; PRAMEF5; -.
DR HGNC; HGNC:27995; PRAMEF5.
DR HPA; ENSG00000270601; Not detected.
DR neXtProt; NX_Q5TYX0; -.
DR OpenTargets; ENSG00000270601; -.
DR PharmGKB; PA142671142; -.
DR VEuPathDB; HostDB:ENSG00000270601; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR InParanoid; Q5TYX0; -.
DR OMA; VCTHMEP; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; Q5TYX0; -.
DR SignaLink; Q5TYX0; -.
DR BioGRID-ORCS; 343068; 285 hits in 978 CRISPR screens.
DR GenomeRNAi; 343068; -.
DR Pharos; Q5TYX0; Tdark.
DR PRO; PR:Q5TYX0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TYX0; protein.
DR Bgee; ENSG00000270601; Expressed in ascending aorta.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..476
FT /note="PRAME family member 5"
FT /id="PRO_0000156979"
FT REPEAT 97..124
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 179..203
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 204..230
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 231..266
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 267..292
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 293..324
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 325..345
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 349..376
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 377..401
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT CONFLICT 16
FT /note="S -> N (in Ref. 2; AAI01345)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="M -> L (in Ref. 2; AAI30275/AAI30277)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="Q -> R (in Ref. 2; AAI01345/AAI30275/AAI30277)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="C -> Y (in Ref. 2; AAI01345/AAI30275/AAI30277)"
FT /evidence="ECO:0000305"
FT CONFLICT 344
FT /note="L -> P (in Ref. 2; AAI01345/AAI30275/AAI30277)"
FT /evidence="ECO:0000305"
FT CONFLICT 416
FT /note="P -> L (in Ref. 2; AAI30275/AAI30277)"
FT /evidence="ECO:0000305"
FT CONFLICT 432
FT /note="P -> A (in Ref. 2; AAI01345/AAI30275/AAI30277)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 476 AA; 54886 MW; 7479352E27ABF582 CRC64;
MSIRTPPRLL ELAGRSLLRD QALAMSTLEE LPTELFPPLF MEAFSRRRCE ALKLMVQAWP
FRRLPLRPLI KMPCLEAFQA VLDGLDALLT QGVHPRRWKL QVLDLQDVCE NFWMVWSEAM
AHGCFLNAKR NKKPVQDCPR MRGQQPLTVF VELWLKNRTL DEYLTCLLLW VKQRKDLLHL
CCKKLKILGM PFRNIRSILK MVNLDCIQEV EVNCKWVLPI LTQFTPYLGH MRNLQKLVLS
HMDVSRYVSP EQKKEIVTQF TTQFLKLCCL QKLSMNSVSF LEGHLDQLLS CLKTSLKVLT
ITNCVLLESD LKHLSQCPSI SQLKTLDLSG IRLTNYSLVP LQILLEKVAA TLEYLDLDDC
GIIDSQVNAI LPALSRCFEL NTFSFCGNPI SMATLENLLS HTIILKNLCV ELYPAPRESY
DADGTLCWSR FPQIRAELMK RVRDLRHPKR ILFCTDCCPD CGNRSFYDLE ADQCCC
