PRAM8_HUMAN
ID PRAM8_HUMAN Reviewed; 474 AA.
AC Q5VWM4; A6NMC2; B7ZMI5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-2015, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=PRAME family member 8 {ECO:0000312|HGNC:HGNC:24074};
GN Name=PRAMEF8 {ECO:0000312|HGNC:HGNC:24074}; Synonyms=PRAMEF24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AC244216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC144565; AAI44566.1; -; mRNA.
DR CCDS; CCDS72709.1; -.
DR RefSeq; NP_001012276.2; NM_001012276.3.
DR RefSeq; XP_016856758.1; XM_017001269.1.
DR AlphaFoldDB; Q5VWM4; -.
DR SMR; Q5VWM4; -.
DR STRING; 9606.ENSP00000349931; -.
DR iPTMnet; Q5VWM4; -.
DR PhosphoSitePlus; Q5VWM4; -.
DR BioMuta; PRAMEF8; -.
DR DMDM; 74756937; -.
DR PaxDb; Q5VWM4; -.
DR PeptideAtlas; Q5VWM4; -.
DR PRIDE; Q5VWM4; -.
DR Antibodypedia; 68110; 52 antibodies from 10 providers.
DR DNASU; 391002; -.
DR Ensembl; ENST00000357367.6; ENSP00000349931.2; ENSG00000182330.10.
DR Ensembl; ENST00000611408.1; ENSP00000478860.1; ENSG00000278021.4.
DR Ensembl; ENST00000614831.1; ENSP00000484204.1; ENSG00000182330.10.
DR Ensembl; ENST00000616484.4; ENSP00000480509.1; ENSG00000278021.4.
DR Ensembl; ENST00000621519.4; ENSP00000484753.1; ENSG00000182330.10.
DR Ensembl; ENST00000631760.1; ENSP00000488367.1; ENSG00000282583.1.
DR Ensembl; ENST00000632222.1; ENSP00000488892.1; ENSG00000282583.1.
DR Ensembl; ENST00000632952.1; ENSP00000488817.1; ENSG00000282583.1.
DR Ensembl; ENST00000636073.1; ENSP00000490581.1; ENSG00000283387.1.
DR Ensembl; ENST00000637866.1; ENSP00000490715.1; ENSG00000283387.1.
DR Ensembl; ENST00000637989.1; ENSP00000490790.1; ENSG00000283387.1.
DR GeneID; 391002; -.
DR KEGG; hsa:391002; -.
DR MANE-Select; ENST00000357367.7; ENSP00000349931.2; NM_001012276.3; NP_001012276.2.
DR UCSC; uc031tpu.2; human.
DR UCSC; uc031tpv.2; human.
DR CTD; 391002; -.
DR GeneCards; PRAMEF8; -.
DR HGNC; HGNC:24074; PRAMEF8.
DR HPA; ENSG00000182330; Not detected.
DR neXtProt; NX_Q5VWM4; -.
DR OpenTargets; ENSG00000182330; -.
DR PharmGKB; PA142671145; -.
DR VEuPathDB; HostDB:ENSG00000182330; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; Q5VWM4; -.
DR OMA; GCWISES; -.
DR OrthoDB; 631249at2759; -.
DR TreeFam; TF332708; -.
DR PathwayCommons; Q5VWM4; -.
DR BioGRID-ORCS; 391002; 14 hits in 1024 CRISPR screens.
DR GenomeRNAi; 391002; -.
DR Pharos; Q5VWM4; Tdark.
DR PRO; PR:Q5VWM4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VWM4; protein.
DR Bgee; ENSG00000182330; Expressed in liver and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..474
FT /note="PRAME family member 8"
FT /id="PRO_0000156982"
FT REPEAT 97..122
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 177..201
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 202..228
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 229..264
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 265..290
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 291..322
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 323..341
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 347..374
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 375..399
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 474 AA; 53655 MW; 73F5231BC6EB3B29 CRC64;
MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE TLKTMVQAWP
FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL QVLDLRNVDE NFCDIFSGAT
ASFPEALSQK QTADNCPGTG RQQPFMVFID LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC
KELQVFGMPI HSIIEVLNMV ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI
RASACIPPDN KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT
DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL QTLDLEDCGI
MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT VGLSKLSLEL YPAPLESYDT
QGALCWGRFA ELGAELMNTL RDLRQPKIIV FCTVPCPRCG IRASYDLEPS HCLC
