ID   PRA_MYCTO               Reviewed;         240 AA.
AC   P9WIM6; L0T785; O53426;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Proline-rich antigen homolog {ECO:0000250|UniProtKB:P41484};
DE            Short=Pra {ECO:0000250|UniProtKB:P41484};
GN   Name=pra {ECO:0000250|UniProtKB:P41484}; OrderedLocusNames=MT1109;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mycobacterial Pra family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK45365.1; -; Genomic_DNA.
DR   PIR; D70894; D70894.
DR   RefSeq; WP_003901991.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIM6; -.
DR   EnsemblBacteria; AAK45365; AAK45365; MT1109.
DR   KEGG; mtc:MT1109; -.
DR   PATRIC; fig|83331.31.peg.1194; -.
DR   HOGENOM; CLU_053152_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010432; RDD.
DR   Pfam; PF06271; RDD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..240
FT                   /note="Proline-rich antigen homolog"
FT                   /id="PRO_0000427979"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          89..233
FT                   /note="RDD"
FT                   /evidence="ECO:0000255"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   240 AA;  25076 MW;  C9B142E6CC1A2609 CRC64;
     MTEQPPPGGS YPPPPPPPGP SGGHEPPPAA PPGGSGYAPP PPPSSGSGYP PPPPPPGGGA
     YPPPPPSAGG YAPPPPGPAI RTMPTESYTP WITRVLAAFI DWAPYVVLVG IGWVIMLVTQ
     TSSCVTSISE YDVGQFCVSQ PSMIGQLVQW LLSVGGLAYL VWNYGYRQGT IGSSIGKSVL
     KFKVVSETTG QPIGFGMSVV RQLAHFIDAI ICFVGFLFPL WDAKRQTLAD KIMTTVCVPI