PRC2A_MACMU
ID PRC2A_MACMU Reviewed; 2160 AA.
AC Q5TM26;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Protein PRRC2A;
DE AltName: Full=HLA-B-associated transcript 2;
DE AltName: Full=Proline-rich and coiled-coil-containing protein 2A;
GN Name=PRRC2A; Synonyms=BAT2;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15269276; DOI=10.1093/molbev/msh216;
RA Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT "Rhesus macaque class I duplicon structures, organization, and evolution
RT within the alpha block of the major histocompatibility complex.";
RL Mol. Biol. Evol. 21:2079-2091(2004).
CC -!- FUNCTION: May play a role in the regulation of pre-mRNA splicing.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; AB128049; BAD69719.1; -; Genomic_DNA.
DR RefSeq; NP_001108429.1; NM_001114957.1.
DR RefSeq; XP_014991419.1; XM_015135933.1.
DR AlphaFoldDB; Q5TM26; -.
DR STRING; 9544.ENSMMUP00000007009; -.
DR GeneID; 715715; -.
DR KEGG; mcc:715715; -.
DR CTD; 7916; -.
DR eggNOG; KOG4817; Eukaryota.
DR InParanoid; Q5TM26; -.
DR OrthoDB; 17901at2759; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR InterPro; IPR009738; BAT2_N.
DR InterPro; IPR033184; PRRC2.
DR PANTHER; PTHR14038; PTHR14038; 1.
DR Pfam; PF07001; BAT2_N; 1.
PE 3: Inferred from homology;
KW Acetylation; Cytoplasm; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..2160
FT /note="Protein PRRC2A"
FT /id="PRO_0000064830"
FT REPEAT 41..95
FT /note="1-1"
FT REPEAT 98..154
FT /note="1-2"
FT REPEAT 281..336
FT /note="1-3"
FT REPEAT 337..430
FT /note="2-1"
FT REPEAT 488..561
FT /note="2-2"
FT REPEAT 1760..1815
FT /note="1-4"
FT REPEAT 1919..1968
FT /note="3-1"
FT REPEAT 1985..2034
FT /note="3-2"
FT REPEAT 2060..2109
FT /note="3-3"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..1815
FT /note="4 X 57 AA type A repeats"
FT REGION 49..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..561
FT /note="2 X type B repeats"
FT REGION 740..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1782..1801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1807..1885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1919..2109
FT /note="3 X 50 AA type C repeats"
FT REGION 2065..2160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..421
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..541
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..615
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..714
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..871
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..967
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1463
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1474..1494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1520
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1557..1573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1645..1673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1713
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1843..1859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2065..2113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2135..2151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 27
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 35
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 204
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 272
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 296
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 342
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 350
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 363
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 380
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 383
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 456
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 610
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 759
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 761
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 764
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 807
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 808
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 907
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 911
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 935
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1000
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1007
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1069
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1086
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1088
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1092
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1095
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1097
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1109
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1113
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1150
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1199
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1222
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1309
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1313
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1326
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1328
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1331
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1350
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1356
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1387
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1389
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1781
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 2039
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 2079
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 2085
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 2116
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
SQ SEQUENCE 2160 AA; 229049 MW; 6FB936E101BB8BEE CRC64;
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA
NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN
QPKRPPAAPE NTPLVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD
KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGALQPSGP
PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHKD
SQSASGEERP TEADGKKGNS PNSELPPPKT AWAETSRPPE TEPGPPAPKP PLPPPHRGPA
GNWGPPGDYP DRGGPPCKPP APEDEDEAWR QRRKQSSSEI SLAVERARRR REEEERRMQE
ERRAACAEKL KRLDEKFGAP DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PLAPSPASAP
TPEKEPEESA QAPPAQCTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE
PPEEVPPPTT PPAPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ QQEQLLKQQQ
QQQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP KALYPGALGR PPPMPPMNFD
PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP SGLVPRERSD SGGSSSEPFD RHAPAMLRER
GTPPVDPKLA WVGDVFTATP TDPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG
FPENGAPGPP VSRFPLEEPA PPGPRPLPWP PGSDEGAKIQ TQPPKKEPPK EETAQLTGPE
AGRKPARGVG SGGQGPPPPR RESRTETRWG PRPGSSRRGI PPEEPGAPPR RAGPIKKPPP
PTKVEELPPK PLEQGDETPK APKPDPLKIA KGKLAGPKET PPNGNLSPAP RLRRDYSYER
VGPTSCRGRG RGEYFARGRG FRGTYGGRGR GARSREFRSY REFRGDDGRG GGTGGPNHPP
APRGRTASET RSEGSEYEEI PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGTLTQVPL
APPPPGAPPS PAPARFTARG GRVFTPRGVP SRRGRGGGRP PPQVCPGWSP PAKSLAPKKP
PTGPLPPSKE PLKEKLIPGP LSPVARGGSS GGSNVGMEDG ERPRRRRHGR AQQQDKPPRF
RRLKQERENA ARGSEGKPSL TLPASTPGPE EALTTVTVAP PPRRAAAKSP DLSNQNSDQA
NEEWETASES SDFASERRGD KEAPPPALLT PKAVGTPGGG GGGAVPGISA MSRGDLSQRA
KDLSKRSFSS QRPGMERQNR RPGPGGKAGS SGSSSGGGGA GPGGRTGPGR GDKRSWPSPK
NRSRPPEERP PGLPLPPPPP SSSAVFRLDQ VIHSNPAGIQ QALAQLSSRQ GSVTAPGGHP
RHKPGPPQTP QGPSPRPPTR YEPQRVNNGL SSDPHFEEPG PMVRGVGGTP RDSARVSPFP
AKRRERPPRK PELLQEESLP PPHSSGFLGS KPEGPGPQAE SRDTGTEALT PHIWNRLHTA
TSRKSYRPSS MEPWMEPLSP FEDVAGTEMS QSDSGVDLSG DSQVSSGPCS QRSSPDGGLK
GAAEGPPKRP GGPSPLNAVP CEGPPGSEPP RRPPPAPHDG DRKELPREQP LPPGPIGTER
SQRTDRGTEP GPIRPSHLPG PPVQFDTSDK DSDLRLVVGD SLKAEKELTA SVTEAIPVSR
DWELLPSAAA SAEPQSKNLG SGHCGPEPPS SGQRLYPEVF YGSAGPSSSQ ISGGAMDSQL
HPNSGGFRPG TPSLHPYRSQ PLYLPPGPAP PSALLSGVAL KGQFLDFSTL QAAELGKLPA
GGVLYPPPSF LYSPAFCPSP LPDTSLLQVR QDLPSPSDFY STPLQPGGQS GFLPSGAPAQ
QMLLPMVDSQ LPVVNFGSLP PAPPPAPPPL SLLPVGPALQ PPSLAVRPPP APATRVLPSP
ARPFPASLGR AELHPVELKP FQDYQKLSSN LGGPGSSRTP PTGRSFSGLN SRLKAPPSTY
SGVFRTQRID LYQQASPPDA LRWIPKPWER TGPPSREGPS RRAEEPGSRG DKEPGLPPPR
