PRC2A_RAT
ID PRC2A_RAT Reviewed; 2161 AA.
AC Q6MG48;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein PRRC2A;
DE AltName: Full=HLA-B-associated transcript 2;
DE AltName: Full=Proline-rich and coiled-coil-containing protein 2A;
GN Name=Prrc2a; Synonyms=Bat2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1406, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT regulation of aquaporin-2 phosphorylation at two sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-762;
RP SER-765; SER-809; SER-1007; SER-1088; SER-1113; SER-1150; SER-1222;
RP SER-1761 AND SER-2117, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May play a role in the regulation of pre-mRNA splicing.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; BX883046; CAE83998.1; -; Genomic_DNA.
DR RefSeq; NP_997627.1; NM_212462.2.
DR RefSeq; XP_006256114.1; XM_006256052.3.
DR AlphaFoldDB; Q6MG48; -.
DR SMR; Q6MG48; -.
DR BioGRID; 254634; 1.
DR IntAct; Q6MG48; 2.
DR MINT; Q6MG48; -.
DR STRING; 10116.ENSRNOP00000001133; -.
DR iPTMnet; Q6MG48; -.
DR PhosphoSitePlus; Q6MG48; -.
DR jPOST; Q6MG48; -.
DR PaxDb; Q6MG48; -.
DR PRIDE; Q6MG48; -.
DR GeneID; 294250; -.
DR KEGG; rno:294250; -.
DR UCSC; RGD:1303025; rat.
DR CTD; 7916; -.
DR RGD; 1303025; Prrc2a.
DR VEuPathDB; HostDB:ENSRNOG00000000852; -.
DR eggNOG; KOG4817; Eukaryota.
DR HOGENOM; CLU_001247_1_0_1; -.
DR InParanoid; Q6MG48; -.
DR OrthoDB; 17901at2759; -.
DR PhylomeDB; Q6MG48; -.
DR PRO; PR:Q6MG48; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000000852; Expressed in thymus and 20 other tissues.
DR ExpressionAtlas; Q6MG48; baseline and differential.
DR Genevisible; Q6MG48; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR InterPro; IPR009738; BAT2_N.
DR InterPro; IPR033184; PRRC2.
DR PANTHER; PTHR14038; PTHR14038; 1.
DR Pfam; PF07001; BAT2_N; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..2161
FT /note="Protein PRRC2A"
FT /id="PRO_0000064832"
FT REPEAT 41..95
FT /note="1-1"
FT REPEAT 98..154
FT /note="1-2"
FT REPEAT 281..336
FT /note="1-3"
FT REPEAT 337..429
FT /note="2-1"
FT REPEAT 487..560
FT /note="2-2"
FT REPEAT 1760..1815
FT /note="1-4"
FT REPEAT 1920..1969
FT /note="3-1"
FT REPEAT 1986..2035
FT /note="3-2"
FT REPEAT 2061..2110
FT /note="3-3"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..1815
FT /note="4 X 57 AA type A repeats"
FT REGION 49..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..560
FT /note="2 X type B repeats"
FT REGION 738..1774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1920..2110
FT /note="3 X 50 AA type C repeats"
FT REGION 1948..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2024..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2065..2161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..542
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..614
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..716
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..872
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..968
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1460
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1519
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1555..1570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1705..1728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1811..1828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1845..1879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1955..1970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2040
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2070..2114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2136..2152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 27
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 35
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 204
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 272
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 296
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 342
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 350
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 363
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 378
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 455
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 609
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 760
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 762
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 765
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 808
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 809
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 908
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 936
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1000
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1007
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1069
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1086
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1088
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1092
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1095
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1097
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1109
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1113
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1150
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1199
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1222
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1311
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1324
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1326
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSC1"
FT MOD_RES 1329
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1348
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1354
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1387
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 1406
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:16641100"
FT MOD_RES 1761
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 2040
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 2086
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P48634"
FT MOD_RES 2117
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 2161 AA; 229047 MW; 8843EDDB4443C6AD CRC64;
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA
NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN
QPKRPPTAPE NTPSVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD
KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP
PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHKD
SQSAAGEEPE TDGKKGTSPG SELPPPKTAW TENSRPSETE PAAPPIPKPP PPPPHRGPVG
NWGPPGDYPD RGGPPCKPPA PEDEDEAWRQ RRKQSSSEIS LAVERARRRR EEEERRMQEE
RRAACAEKLK RLDEKFGAPD KRLKAEPAAP PVTPPAPALP PVVPKETPTP PALPPTPTPT
PEKDPEEPAH APPVQSAPTQ AGPPAPTPVS GGGTASSTSS GSFEASPAEP QLPSKEGPEP
PEEVPAPTTP PAPKVEPKGD GVGPTRQPPS QGLGYPKYQK SLPPRFQRQQ QEQLLKQQQQ
QQWQQQQQQQ GTAPPAPVPP SPPQPVTLGA VPAPQAPPPP PKALYPGALG RPPPMPPMNF
DPRWMMIPPY VDPRLLQGRP PLDFYPPGVH PSGLVPRERS DSGGSSSEPF ERHAPPLLRE
RGTPPVDPKL AWVGDVFTTT PTDPRPLTSP LRQAADEEEK SLRSETPPVP PPPPYLANYP
GFPENGTPGP PISRFPLEES APPGPRPLPW PPGNDEAAKM QAPPPKKEPP KEEPAQLSGP
EAGRKPARGV GGGGQGPPPP RRENRTETRW GPRPGSCRRG IPPEDPGVPP RRAGPIKKPP
PPVKADELPP KSLEPGDETP KAPKPDALKT AKGKVGPKET PAGGNLSPAP RLRRDYSYER
VGPTSCRGRG RGEYFARGRG FRGTYGGRGR GARSREFRSY REFRGDDGRG GGSGGTNHPS
APRGRTASET RSEGSEYEEI PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGVLAQVPL
APPQPGAPPS PAPARFSTAR GGRVFTPRGV PSRRGRGGGR PPPVCSGWSP PAKSLVPKKP
PTGPLPPNKE PLKEKLISGP LSPMSRAGNM GVGMEDGERP RRRRHGRAQQ QDKPPRFRRL
KQDRENAARG TDGKPPPLTL PASTPAPTET LATVAAPPPP RRTAAKSPDL SNQNSDQANE
EWETASESSD FASERRGDKE TPPAALITSK AVGTPGGNSG GAGPGISTMS RGDLSQRAKD
LSKRSFSSQR PGMDRQNRRP GAGGKTGGGG SSGGGGAGPG GRTGPGRGDK RSWPSPKNRS
RPPEERPPGL PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGNV TAPGGHPRPK
PGPPQAPQGS SPRPPTHYDP PRASNAISSD PHFEEPGPMV RGVGGTPRDS AGVNPFPPKR
RERPPRKPEL LQEETVPASH SSGFLGSKPE VPGPQEESRD SGTEALTPHI WNRLHTATSR
KSYQPGSIEP WMEPLSPFED VAGTEMSQSD SGVDLSGGSQ VSSGPCSQRS SPDGGLKGSA
EGPPRRPGGP SPLKAVPGES SSASEPSEPH RRRPPASHEG ERKELPREQP LPPGPIGTER
SQRTDRGPEP GPLRPAHRAG SQVEFGTTNK DSDLCLVVGD TLKGEKELAA SATEAVPVSR
DWELLPSASA SAEPQAKSLG SGQCGPEPSP SGQRLYPEVF YGSPGPPNSQ VSGGAPIDSQ
LHPSSGGFRP GTPSVHQYRS QPLYLPPGPA PPSALLSGVA LKGQFLDFSA LQATELGKLP
AGGVLYPPPS FLYSAAFCPS PLPDPPLLQV RQDLPSPSDF YSTPLQPGGQ SGFLPSGAPA
QQMLLPVVDS QLPVVNFGSL PPAPPPAPPP LSLLPVGPAL QPPNLAVRPP PAPAARVLPS
PARPFPASLG RAELHPVELK PFQDYRKLSS NLGGPGSSRA PPSGRSFSGL NSRLKAPPST
YSGVFRTQRI DLYQQASPPD ALRWMPKPWE RTGPPSREGP PRRAEEPGPR GEKEPGLPPP
R
