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PRC2B_MOUSE
ID   PRC2B_MOUSE             Reviewed;        1486 AA.
AC   Q7TPM1; A2AN31; Q8C755;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Protein PRRC2B;
DE   AltName: Full=HLA-B-associated transcript 2-like 1;
DE   AltName: Full=Proline-rich coiled-coil protein 2B;
GN   Name=Prrc2b; Synonyms=Bat2l, Bat2l1, Kiaa0515;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Lung;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222; SER-387 AND SER-415, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Lung, Pancreas, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7TPM1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7TPM1-2; Sequence=VSP_022764, VSP_022765;
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DR   EMBL; AK052511; BAC35022.1; -; mRNA.
DR   EMBL; AL808027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC055116; AAH55116.1; -; mRNA.
DR   CCDS; CCDS15907.1; -. [Q7TPM1-1]
DR   RefSeq; NP_001153106.1; NM_001159634.1.
DR   RefSeq; NP_766249.2; NM_172661.3. [Q7TPM1-1]
DR   AlphaFoldDB; Q7TPM1; -.
DR   BioGRID; 230675; 13.
DR   IntAct; Q7TPM1; 5.
DR   MINT; Q7TPM1; -.
DR   STRING; 10090.ENSMUSP00000035734; -.
DR   iPTMnet; Q7TPM1; -.
DR   PhosphoSitePlus; Q7TPM1; -.
DR   EPD; Q7TPM1; -.
DR   jPOST; Q7TPM1; -.
DR   MaxQB; Q7TPM1; -.
DR   PaxDb; Q7TPM1; -.
DR   PeptideAtlas; Q7TPM1; -.
DR   PRIDE; Q7TPM1; -.
DR   ProteomicsDB; 291859; -. [Q7TPM1-1]
DR   ProteomicsDB; 291860; -. [Q7TPM1-2]
DR   DNASU; 227723; -.
DR   Ensembl; ENSMUST00000036691; ENSMUSP00000035734; ENSMUSG00000039262. [Q7TPM1-1]
DR   GeneID; 227723; -.
DR   KEGG; mmu:227723; -.
DR   UCSC; uc008jem.2; mouse. [Q7TPM1-1]
DR   CTD; 84726; -.
DR   MGI; MGI:1923304; Prrc2b.
DR   VEuPathDB; HostDB:ENSMUSG00000039262; -.
DR   eggNOG; KOG4817; Eukaryota.
DR   GeneTree; ENSGT00950000183161; -.
DR   HOGENOM; CLU_001247_0_0_1; -.
DR   InParanoid; Q7TPM1; -.
DR   OrthoDB; 17901at2759; -.
DR   TreeFam; TF328738; -.
DR   BioGRID-ORCS; 227723; 5 hits in 72 CRISPR screens.
DR   ChiTaRS; Prrc2b; mouse.
DR   PRO; PR:Q7TPM1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q7TPM1; protein.
DR   Bgee; ENSMUSG00000039262; Expressed in superior cervical ganglion and 234 other tissues.
DR   ExpressionAtlas; Q7TPM1; baseline and differential.
DR   Genevisible; Q7TPM1; MM.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR   InterPro; IPR009738; BAT2_N.
DR   InterPro; IPR033184; PRRC2.
DR   PANTHER; PTHR14038; PTHR14038; 2.
DR   Pfam; PF07001; BAT2_N; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..1486
FT                   /note="Protein PRRC2B"
FT                   /id="PRO_0000274482"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          792..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          893..918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          950..1080
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1177..1205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1410..1443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1455..1486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          494..544
FT                   /evidence="ECO:0000255"
FT   COILED          880..904
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..519
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..658
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        822..847
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        950..1011
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1025..1072
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1181..1205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1459..1476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         222
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         226
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         228
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         387
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:16452087,
FT                   ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079"
FT   MOD_RES         415
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         479
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         555
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         621
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         753
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         762
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         793
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         1070
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   MOD_RES         1159
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   CROSSLNK        251
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   CROSSLNK        751
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSZ5"
FT   VAR_SEQ         1..766
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_022764"
FT   VAR_SEQ         1475..1486
FT                   /note="QSEWMKNPAWEP -> PSSASPSGKPSGSAVNMGSVQGHYVQQAKRVDEKPG
FT                   LGTVKLQEASSATSQMKRTGAIKPRAVKVEGSKA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_022765"
FT   CONFLICT        1342
FT                   /note="P -> S (in Ref. 1; BAC35022)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1486 AA;  160913 MW;  53BF3D0BD583D731 CRC64;
     MSDRLGQITQ GKDGKSKYST LSLFDKYKGR SVGAVRSSVI PRHGLQSLGK VATARRMPPP
     ANLPSLKSEN KGNDPNIVIV PKDGTGWANK QDQQDPKSSS VTASQPPESQ PQPGLQKSVS
     NLQKPTQSIS QENTNSVPGG PKSWAQLSGK PVGHEGGLRG SSRLLSFSPE EFPTLKAAGG
     QDKAGKEKGA LDLSYGPGPS LRPQNVTSWR EGGGRNIISA ASLSASPTEL GSRNASGADG
     APSLACTSDS KEPSLRPAQP SRRGASQFMG HGYQPPTYHD MLPAFMCSPQ SSENQTTVER
     SSFPLPQLRL EPRVPFRQFQ MNDQDGKERP GVARPVRPLR QLVERAPRPT IINAENLKGL
     DDLDTDADDG WAGLHEEVDY SEKLKFSDDE DEEDVVKDGR SKWNNWDPRR QRALSLSSAD
     STDAKRTQEE GKDWSGTAGG SRVIRKVPEP QPPSRKLHSW ASGPDYQKPT MGSMFRQHSA
     EDKEDKPPPR QKFIQSEMSE AVERARKRRE EEERRAREER LAACAAKLKQ LDQKCRQAQK
     ANETPKPVEK EVPRSPGIEK VSPPENGPVV RKGSPEFPVQ EAPTMFLEET PATSPTVAQS
     NSSSSSSSSS SIEEEVRESG SPAQEFSKYQ KSLPPRFQRQ QQQQQQQQQQ QQQQEQLYKM
     QHWQPVYPPP SHPQRTFYPH HPQMLGFDPR WMMMPSYMDP RITPTRTPVD FYPSALHPSG
     LMKPMMPQES LSGTGCRSED QNCVPSLQER KVTALDPAPV WSPEGYMALQ NKGYSLPHPK
     SADTLAMGMH VRSPDEALPG GLGSHSPYAL ERTTHASSDG PETPSKKSER EVSLPTQRAS
     EQEEARKQFD LGYGNALIDN CASSPGEENE ASSVVGEGFI EVLTKKQRRL LEEERRKKEQ
     AAQVPVKGRG LSSRIPPRFA KKQNGLCLEQ DVTVPGSSLG TEIWENSSQA LPVQGAASDS
     WRTAVTAFSS TEPGTSEQGF KSSQGDSGVD LSAESRESSA TSSQRSSPYG TLKPEEISGP
     GLAESKADSH KDQAQKQAEH KDSEQGSAQS KEHRPGPIGN ERSLKNRKGS EGAERLPGAV
     VPPVNGVEIH VDSVLPVPPI EFGVSPKDSD FSLPPGSVSG PVGNPVAKLQ DVLASNAGLT
     QSIPILRRDH HMQRAIGLSP MSFPTADLTL KMESARKAWE NSPSLPEQSS PGGAGSGIQP
     PSSVGASNGV NYSSFGGVSM PPMPVASVAP SASIPGSHLP PLYLDGHVFA SQPRLVPQTI
     PQQQSYQQAA TAQQIPISLH TSLQAQAQLG LRGGLPVSQS QEIFSSLQPF RSQVYMHPSL
     SPPSTMILSG GTALKPPYSA FPGIQPLEMV KPQSGSPYQP MSGNQALVYE GQLGQAAGLG
     TSQMLDSQLP QLTMPLPRYG SGQQPLILPQ SIQLPPGQSL SVGAPRRVPP PGSQPPVLNT
     SRESAPMELK GFHFADSKQN VPTGGSAPSP QAYRQSEWMK NPAWEP
 
 
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