PRCA1_MOUSE
ID PRCA1_MOUSE Reviewed; 307 AA.
AC B0QZF7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Protein PROCA1;
GN Name=Proca1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SIMILARITY: Belongs to the PROCA1 family. {ECO:0000305}.
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DR EMBL; AL591070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS88201.1; -.
DR RefSeq; XP_006533026.1; XM_006532963.3.
DR AlphaFoldDB; B0QZF7; -.
DR STRING; 10090.ENSMUSP00000086022; -.
DR iPTMnet; B0QZF7; -.
DR PhosphoSitePlus; B0QZF7; -.
DR PaxDb; B0QZF7; -.
DR PRIDE; B0QZF7; -.
DR ProteomicsDB; 289398; -.
DR Antibodypedia; 14279; 78 antibodies from 14 providers.
DR Ensembl; ENSMUST00000108317; ENSMUSP00000103953; ENSMUSG00000044122.
DR UCSC; uc007kin.1; mouse.
DR MGI; MGI:1918274; Proca1.
DR VEuPathDB; HostDB:ENSMUSG00000044122; -.
DR eggNOG; ENOG502QTYI; Eukaryota.
DR GeneTree; ENSGT00940000162235; -.
DR HOGENOM; CLU_803998_0_0_1; -.
DR InParanoid; B0QZF7; -.
DR OMA; FSDCGHH; -.
DR OrthoDB; 1306595at2759; -.
DR BioGRID-ORCS; 216974; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Proca1; mouse.
DR PRO; PR:B0QZF7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; B0QZF7; protein.
DR Bgee; ENSMUSG00000044122; Expressed in seminiferous tubule of testis and 135 other tissues.
DR ExpressionAtlas; B0QZF7; baseline and differential.
DR Genevisible; B0QZF7; MM.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0030332; F:cyclin binding; ISO:MGI.
DR GO; GO:0004623; F:phospholipase A2 activity; IEA:InterPro.
DR GO; GO:0050482; P:arachidonic acid secretion; IEA:InterPro.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; ISS:UniProtKB.
DR GO; GO:0035694; P:mitochondrial protein catabolic process; ISS:UniProtKB.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.90.10; -; 1.
DR InterPro; IPR036444; PLipase_A2_dom_sf.
PE 3: Inferred from homology;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..307
FT /note="Protein PROCA1"
FT /id="PRO_0000336064"
FT REGION 134..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 220
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT MOD_RES 250
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT MOD_RES 259
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT MOD_RES 260
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT MOD_RES 298
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V7B4"
SQ SEQUENCE 307 AA; 34900 MW; 2D6EC64787493840 CRC64;
MWVRTTITVK RWTEERSGRK IERTERTDIT RLPSWKRGYP ASVDSSSDLF SFSEGENKET
DRRCWKHQHC PGHTIHPFSD CGHHNRCMHA VSQCDCESRC RSHRPVSVAI IYHPTHHMYM
TDDDLEENWV SRKNHLSPSA RPPDPNTGSA TEVPDLSVPI TIWRSESPIE KCQESNVIKD
IKRKEKEQDE EEMVDEKANL KKKAKGKLTK KKTPVKSESS PADLSQSVRG PVRTPESSPE
SPGGLESEYS CERGKERPSS EDVVESLSPR KKEKTSSGQA KKNGTKKETQ KTSKRKKSSP
VPNPNLS