ID   PRCD_BOVIN              Reviewed;          54 AA.
AC   E1B7R9;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Photoreceptor disk component PRCD {ECO:0000303|PubMed:23672200};
DE   AltName: Full=Progressive rod-cone degeneration protein {ECO:0000303|PubMed:23672200};
GN   Name=PRCD {ECO:0000303|PubMed:23672200};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000312|Proteomes:UP000009136};
RN   [1] {ECO:0000312|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=23672200; DOI=10.1021/pr4003678;
RA   Skiba N.P., Spencer W.J., Salinas R.Y., Lieu E.C., Thompson J.W.,
RA   Arshavsky V.Y.;
RT   "Proteomic identification of unique photoreceptor disc components reveals
RT   the presence of PRCD, a protein linked to retinal degeneration.";
RL   J. Proteome Res. 12:3010-3018(2013).
RN   [3] {ECO:0000305}
RP   INTERACTION WITH RHO, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   PALMITOYLATION AT CYS-2, AND PHOSPHORYLATION.
RX   PubMed=27509380; DOI=10.1021/acs.biochem.6b00489;
RA   Spencer W.J., Pearring J.N., Salinas R.Y., Loiselle D.R., Skiba N.P.,
RA   Arshavsky V.Y.;
RT   "Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-
RT   Acylation and Rhodopsin Binding for Photoreceptor Outer Segment
RT   Localization and Maintaining Intracellular Stability.";
RL   Biochemistry 55:5028-5037(2016).
CC   -!- FUNCTION: Involved in vision. {ECO:0000250|UniProtKB:Q00LT1}.
CC   -!- SUBUNIT: Interacts with RHO/rhodopsin; the interaction promotes PRCD
CC       stability. {ECO:0000269|PubMed:27509380}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC       segment {ECO:0000269|PubMed:23672200, ECO:0000269|PubMed:27509380}.
CC       Membrane {ECO:0000269|PubMed:27509380}; Lipid-anchor
CC       {ECO:0000269|PubMed:27509380}; Cytoplasmic side
CC       {ECO:0000269|PubMed:27509380}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q00LT1}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q00LT1}. Note=Localizes to photoreceptor disk
CC       membranes in the photoreceptor outer segment.
CC       {ECO:0000269|PubMed:27509380}.
CC   -!- TISSUE SPECIFICITY: Expressed in retina (at protein level).
CC       {ECO:0000269|PubMed:23672200, ECO:0000269|PubMed:27509380}.
CC   -!- PTM: Palmitoylated at Cys-2 (PubMed:27509380). Palmitoylation is
CC       essential for protein stability and trafficking to the photoreceptor
CC       outer segment, but does not appear to be essential for membrane
CC       localization (PubMed:27509380). Probably palmitoylated by ZDHHC3 (By
CC       similarity). {ECO:0000250|UniProtKB:Q00LT2,
CC       ECO:0000269|PubMed:27509380}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:27509380}.
CC   -!- SIMILARITY: Belongs to the PRCD family. {ECO:0000305}.
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DR   EMBL; DAAA02049501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005195905.1; XM_005195848.3.
DR   RefSeq; XP_005195906.1; XM_005195849.3.
DR   RefSeq; XP_005221358.1; XM_005221301.3.
DR   RefSeq; XP_005221359.1; XM_005221302.3.
DR   RefSeq; XP_010814917.1; XM_010816615.2.
DR   RefSeq; XP_010822626.1; XM_010824324.2.
DR   AlphaFoldDB; E1B7R9; -.
DR   STRING; 9913.ENSBTAP00000053128; -.
DR   PaxDb; E1B7R9; -.
DR   eggNOG; ENOG502TE0N; Eukaryota.
DR   HOGENOM; CLU_3175255_0_0_1; -.
DR   InParanoid; E1B7R9; -.
DR   OrthoDB; 1638622at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042622; C:photoreceptor outer segment membrane; IDA:UniProtKB.
DR   GO; GO:0002046; F:opsin binding; IPI:UniProtKB.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   InterPro; IPR027937; PRCD.
DR   PANTHER; PTHR38501; PTHR38501; 1.
DR   Pfam; PF15201; Rod_cone_degen; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Endoplasmic reticulum; Golgi apparatus; Lipoprotein;
KW   Membrane; Palmitate; Phosphoprotein; Reference proteome;
KW   Sensory transduction; Vision.
FT   CHAIN           1..54
FT                   /note="Photoreceptor disk component PRCD"
FT                   /id="PRO_5003143736"
FT   REGION          24..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000269|PubMed:27509380"
SQ   SEQUENCE   54 AA;  5995 MW;  701F3BAE1FF8950F CRC64;
     MCTTLFLLST LAMLWRRRFA NRVQPEPNGV DGAVSGSSLE TDLQSSGREK EPLK