ID   PRCLN_TRIPT             Reviewed;         169 AA.
AC   Q9U6R6;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Procalin {ECO:0000303|PubMed:11509613};
DE   AltName: Allergen=Tria p 1 {ECO:0000305};
DE   Flags: Precursor;
OS   Triatoma protracta (Western bloodsucking conenose) (California kissing
OS   bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Triatoma.
OX   NCBI_TaxID=72493;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Salivary gland;
RX   PubMed=11509613; DOI=10.4049/jimmunol.167.5.2694;
RA   Paddock C.D., McKerrow J.H., Hansell E., Foreman K.W., Hsieh I.,
RA   Marshall N.;
RT   "Identification, cloning, and recombinant expression of procalin, a major
RT   triatomine allergen.";
RL   J. Immunol. 167:2694-2699(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:11509613}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:11509613}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Major salivary antigen.
CC       The insect feeds on mammalian blood; piercing the lips, eyelids or ears
CC       of a sleeping victim. The problem is that the feeding process can cause
CC       anaphylactic shock. {ECO:0000269|PubMed:11509613}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Triabin family.
CC       {ECO:0000305}.
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DR   EMBL; AF179004; AAF07903.2; -; mRNA.
DR   Allergome; 3509; Tria p 1.0101.
DR   Allergome; 998; Tria p 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030682; P:mitigation of host defenses by symbiont; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR005657; Triabi/Procalin.
DR   Pfam; PF03973; Triabin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   Allergen; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..169
FT                   /note="Procalin"
FT                   /evidence="ECO:0000305|PubMed:11509613"
FT                   /id="PRO_0000017995"
FT   DISULFID        21..125
FT                   /evidence="ECO:0000250|UniProtKB:Q27049"
FT   DISULFID        54..168
FT                   /evidence="ECO:0000250|UniProtKB:Q27049"
FT   DISULFID        83..97
FT                   /evidence="ECO:0000250|UniProtKB:Q27049"
SQ   SEQUENCE   169 AA;  19077 MW;  A7A1876885DA912A CRC64;
     MKTFIVITFI GILSYAYADE CENPEPMQGF SASQFYQGXW YVTHETSAXT LSECNILTTS
     NDNGKFTVKH KYTKDGXVGE LICEGQASAN NKFTYDCKFX GZTMEQVTRT AMDTDYNDYA
     LYYLCTTYKX GPNAGKKEGH YILSRRQPNT EIPDALKTKT KDLNLKLCG