ID   PRCT_TITSE              Reviewed;           4 AA.
AC   P0DUS0;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   23-FEB-2022, entry version 2.
DE   RecName: Full=[des-Arg1]-proctolin {ECO:0000303|PubMed:26056922};
DE   AltName: Full=NEP-inhibiting peptide {ECO:0000303|PubMed:26056922};
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND SYNTHESIS.
RC   TISSUE=Venom;
RX   PubMed=26056922; DOI=10.1016/j.peptides.2015.05.013;
RA   Duzzi B., Cajado-Carvalho D., Kuniyoshi A.K., Kodama R.T., Gozzo F.C.,
RA   Fioramonte M., Tambourgi D.V., Portaro F.V., Rioli V.;
RT   "[des-Arg(1)]-proctolin: a novel NEP-like enzyme inhibitor identified in
RT   Tityus serrulatus venom.";
RL   Peptides 80:18-24(2016).
CC   -!- FUNCTION: Venom tetrapeptide that inhibits activities of the human
CC       peptidase neprilysin (NEP/MME) (Ki=0.94 uM), the two mammalian
CC       endopeptidases EP24.16 and EP24.15 (Ki=36 uM and 74 uM, respectively),
CC       and a probable cockroach neprilysin-like protein. It shows 3-fold
CC       better inhibitory activity than proctolin. It may play a role in human
CC       envenomation as well as in the paralysis and death of scorpion preys.
CC       It does not inhibit ACE activity. {ECO:0000269|PubMed:26056922}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26056922}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:26056922}.
CC   -!- MISCELLANEOUS: Is a stable peptide that is not originated from
CC       proctolin hydrolysis. {ECO:0000269|PubMed:26056922}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Secreted.
FT   PEPTIDE         1..4
FT                   /note="[des-Arg1]-proctolin"
FT                   /evidence="ECO:0000269|PubMed:26056922"
FT                   /id="PRO_0000453390"
SQ   SEQUENCE   4 AA;  493 MW;  71B7673B30000000 CRC64;
     YLPT