PRD12_MOUSE
ID PRD12_MOUSE Reviewed; 365 AA.
AC A2AJ77;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=PR domain zinc finger protein 12;
DE EC=2.1.1.-;
DE AltName: Full=PR domain-containing protein 12;
GN Name=Prdm12; Synonyms=Gm998;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=26005867; DOI=10.1038/ng.3308;
RA Chen Y.C., Auer-Grumbach M., Matsukawa S., Zitzelsberger M.,
RA Themistocleous A.C., Strom T.M., Samara C., Moore A.W., Cho L.T.,
RA Young G.T., Weiss C., Schabhuettl M., Stucka R., Schmid A.B., Parman Y.,
RA Graul-Neumann L., Heinritz W., Passarge E., Watson R.M., Hertz J.M.,
RA Moog U., Baumgartner M., Valente E.M., Pereira D., Restrepo C.M.,
RA Katona I., Dusl M., Stendel C., Wieland T., Stafford F., Reimann F.,
RA von Au K., Finke C., Willems P.J., Nahorski M.S., Shaikh S.S.,
RA Carvalho O.P., Nicholas A.K., Karbani G., McAleer M.A., Cilio M.R.,
RA McHugh J.C., Murphy S.M., Irvine A.D., Jensen U.B., Windhager R., Weis J.,
RA Bergmann C., Rautenstrauss B., Baets J., De Jonghe P., Reilly M.M.,
RA Kropatsch R., Kurth I., Chrast R., Michiue T., Bennett D.L., Woods C.G.,
RA Senderek J.;
RT "Transcriptional regulator PRDM12 is essential for human pain perception.";
RL Nat. Genet. 47:803-808(2015).
CC -!- FUNCTION: Involved in the positive regulation of histone H3-K9
CC dimethylation. {ECO:0000269|PubMed:26005867}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4Q4}.
CC -!- DEVELOPMENTAL STAGE: Expression starts around 9.0 dpc in the neural
CC folds, which give rise to neural crest cells. Neural crest cells
CC develop into various tissues, including the sensory ganglia that
CC contain nociceptor cell bodies. Prominently expressed in sensory spinal
CC ganglia (dorsal root ganglia) but not in sympathetic ganglia during the
CC time when sensory neurons emerge (10.5 dpc-13.5 dpc), mature and
CC differentiate (14.5 dpc-postnatal day 14).
CC {ECO:0000269|PubMed:26005867}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR EMBL; AL732564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS50562.1; -.
DR RefSeq; NP_001116834.1; NM_001123362.1.
DR RefSeq; XP_006498224.1; XM_006498161.3.
DR AlphaFoldDB; A2AJ77; -.
DR SMR; A2AJ77; -.
DR STRING; 10090.ENSMUSP00000109098; -.
DR iPTMnet; A2AJ77; -.
DR PhosphoSitePlus; A2AJ77; -.
DR MaxQB; A2AJ77; -.
DR PaxDb; A2AJ77; -.
DR PRIDE; A2AJ77; -.
DR Antibodypedia; 17995; 135 antibodies from 26 providers.
DR Ensembl; ENSMUST00000113470; ENSMUSP00000109098; ENSMUSG00000079466.
DR GeneID; 381359; -.
DR KEGG; mmu:381359; -.
DR UCSC; uc012bto.1; mouse.
DR CTD; 59335; -.
DR MGI; MGI:2685844; Prdm12.
DR VEuPathDB; HostDB:ENSMUSG00000079466; -.
DR eggNOG; KOG2461; Eukaryota.
DR GeneTree; ENSGT00940000161616; -.
DR HOGENOM; CLU_064013_0_1_1; -.
DR InParanoid; A2AJ77; -.
DR OMA; HHANPKT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A2AJ77; -.
DR TreeFam; TF332260; -.
DR BioGRID-ORCS; 381359; 3 hits in 76 CRISPR screens.
DR PRO; PR:A2AJ77; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2AJ77; protein.
DR Bgee; ENSMUSG00000079466; Expressed in cerebral cortex marginal layer and 37 other tissues.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:1990226; F:histone methyltransferase binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; ISO:MGI.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
DR GO; GO:0022008; P:neurogenesis; IDA:MGI.
DR GO; GO:0031175; P:neuron projection development; ISO:MGI.
DR GO; GO:1900111; P:positive regulation of histone H3-K9 dimethylation; ISO:MGI.
DR GO; GO:0051574; P:positive regulation of histone H3-K9 methylation; IDA:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0019233; P:sensory perception of pain; ISO:MGI.
DR CDD; cd19196; PR-SET_PRDM12; 1.
DR Gene3D; 2.170.270.10; -; 1.
DR InterPro; IPR044406; PRDM12_PR/SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR017126; Znf_PRDM12.
DR Pfam; PF00096; zf-C2H2; 2.
DR PIRSF; PIRSF037163; PRDM12; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR SUPFAM; SSF82199; SSF82199; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Methyltransferase; Nucleus; Reference proteome;
KW Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW Transferase; Zinc; Zinc-finger.
FT CHAIN 1..365
FT /note="PR domain zinc finger protein 12"
FT /id="PRO_0000416114"
FT DOMAIN 86..203
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT ZN_FING 243..265
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..323
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 318..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 40303 MW; C8F9EE188F1B3860 CRC64;
MMGSVLPAEA LVLKTGLKAP GLALAEVITS DILHSFLYGR WRNVLGEQLL EDKSHHASPK
TAFTAEVLAQ SFSGEVQKLS SLVLPVEVII AQSSIPGEGL GIFSKTWIKA GTEMGPFTGR
VIAPEHVDIC KNNNLMWEVF NEDGTVRYFI DASQEDHRSW MTYIKCARNE QEQNLEVVQI
GTSIFYKAIE MIPPDQELLV WYGNSHNTFL GIPGVPGLEE EQKKNKHEDF HPADSATGTA
GRMRCVICHR GFNSRSNLRS HMRIHTLDKP FVCRFCNRRF SQSSTLRNHV RLHTGERPYK
CQVCQSAYSQ LAGLRAHQKS ARHRPPSTAL QAHSPALPAP HAHAPALAAA AAAAAAAHHL
PAMVL
