PRD13_MOUSE
ID PRD13_MOUSE Reviewed; 754 AA.
AC E9PZZ1; B1AV74;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=PR domain zinc finger protein 13;
DE EC=2.1.1.-;
DE AltName: Full=PR domain-containing protein 13;
GN Name=Prdm13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=E9PZZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9PZZ1-2; Sequence=VSP_042506;
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR EMBL; AL672159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38699.1; -. [E9PZZ1-1]
DR RefSeq; NP_001074240.1; NM_001080771.1. [E9PZZ1-1]
DR AlphaFoldDB; E9PZZ1; -.
DR SMR; E9PZZ1; -.
DR STRING; 10090.ENSMUSP00000092761; -.
DR PhosphoSitePlus; E9PZZ1; -.
DR PaxDb; E9PZZ1; -.
DR PeptideAtlas; E9PZZ1; -.
DR PRIDE; E9PZZ1; -.
DR ProteomicsDB; 289399; -. [E9PZZ1-1]
DR ProteomicsDB; 289400; -. [E9PZZ1-2]
DR Antibodypedia; 7968; 120 antibodies from 18 providers.
DR Ensembl; ENSMUST00000076206; ENSMUSP00000075562; ENSMUSG00000040478. [E9PZZ1-2]
DR Ensembl; ENSMUST00000095141; ENSMUSP00000092761; ENSMUSG00000040478. [E9PZZ1-1]
DR GeneID; 230025; -.
DR KEGG; mmu:230025; -.
DR UCSC; uc008sco.1; mouse. [E9PZZ1-1]
DR CTD; 59336; -.
DR MGI; MGI:2448528; Prdm13.
DR VEuPathDB; HostDB:ENSMUSG00000040478; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160200; -.
DR HOGENOM; CLU_441855_0_0_1; -.
DR InParanoid; E9PZZ1; -.
DR OMA; ALAQWYD; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF106398; -.
DR BioGRID-ORCS; 230025; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Prdm13; mouse.
DR PRO; PR:E9PZZ1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; E9PZZ1; protein.
DR Bgee; ENSMUSG00000040478; Expressed in retinal neural layer and 10 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042054; F:histone methyltransferase activity; IDA:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0022008; P:neurogenesis; IDA:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd19197; PR-SET_PRDM13; 1.
DR Gene3D; 2.170.270.10; -; 1.
DR InterPro; IPR044407; PRDM13_PR/SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 3.
DR SUPFAM; SSF82199; SSF82199; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW Alternative splicing; DNA-binding; Metal-binding; Methyltransferase;
KW Nucleus; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger.
FT CHAIN 1..754
FT /note="PR domain zinc finger protein 13"
FT /id="PRO_0000416115"
FT DOMAIN 39..160
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT ZN_FING 185..207
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 620..642
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 648..670
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 677..700
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 279..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..400
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..48
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042506"
SQ SEQUENCE 754 AA; 78705 MW; 82E2B2E3B109C37B CRC64;
MPAHVTPRTE DARRGAGPSS ACGCSWFCHL RPVEDPASPS VCLAAVATMH GTSRTSATSV
NADCCIPAGL RLGPVPGTFK LGKYLSDRRE PGPKKKVRMV RGELVDESGG SPLEWIGLIR
AARNPQEQTL EAIADLPGGQ IFYRALRDVQ PGEELTVWYS NSLAQWFDIP TTATPTHDEK
GEERYICWYC WRTFRYPNSL KAHLRFHCVL SGGGGRAFLP QEHAARPGAS PVAEGLGLPP
KPTVPDLTAP VQAIALRPQA PAAQLAQACG ARESIKREAS LAPLATSPPP GKWGTPKKGK
EQPDRAHSQF LGIVGGSSGG GGGLPFYPGV RSAFKPAGLA RAAAQSDPYR EEGGGKGPGL
ALGRLLGGGR AGGRPGSGES PAGHHHHHHH AHHHHHHHPK CLLAGEPPPA GLPCPGALRA
FPLLAGHPEE ASAFKHVERA PPAAATTSLP SARYAALPAP GLPVERCALQ PLDGGSLKAY
PGGGGGGECS PLPAVMPAFT VYSGDLLYGP PAAYYPLKLH LGGLLKYPES ISYLSGPAAA
AAAAAAAAAA AAAIGPAELG SLASIDREIA MHTQQLSEMA AGKSRARLDS GTLPPAVVAA
TGPGGGGGGG SAAGKPKTGH LCLYCGKLYS RKYGLKIHMR THTGYKPLKC KVCLRPFGDP
SNLNKHIRLH AEGNTPYRCE FCGKVLVRRR DLERHVKSRH PGQSLMAKAG DGPGPEPSYA
LEPGDPKSED SDVDVCFTDD QSDPEAGGRG EHDS