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PRD13_MOUSE
ID   PRD13_MOUSE             Reviewed;         754 AA.
AC   E9PZZ1; B1AV74;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=PR domain zinc finger protein 13;
DE            EC=2.1.1.-;
DE   AltName: Full=PR domain-containing protein 13;
GN   Name=Prdm13;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=E9PZZ1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=E9PZZ1-2; Sequence=VSP_042506;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; AL672159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS38699.1; -. [E9PZZ1-1]
DR   RefSeq; NP_001074240.1; NM_001080771.1. [E9PZZ1-1]
DR   AlphaFoldDB; E9PZZ1; -.
DR   SMR; E9PZZ1; -.
DR   STRING; 10090.ENSMUSP00000092761; -.
DR   PhosphoSitePlus; E9PZZ1; -.
DR   PaxDb; E9PZZ1; -.
DR   PeptideAtlas; E9PZZ1; -.
DR   PRIDE; E9PZZ1; -.
DR   ProteomicsDB; 289399; -. [E9PZZ1-1]
DR   ProteomicsDB; 289400; -. [E9PZZ1-2]
DR   Antibodypedia; 7968; 120 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000076206; ENSMUSP00000075562; ENSMUSG00000040478. [E9PZZ1-2]
DR   Ensembl; ENSMUST00000095141; ENSMUSP00000092761; ENSMUSG00000040478. [E9PZZ1-1]
DR   GeneID; 230025; -.
DR   KEGG; mmu:230025; -.
DR   UCSC; uc008sco.1; mouse. [E9PZZ1-1]
DR   CTD; 59336; -.
DR   MGI; MGI:2448528; Prdm13.
DR   VEuPathDB; HostDB:ENSMUSG00000040478; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000160200; -.
DR   HOGENOM; CLU_441855_0_0_1; -.
DR   InParanoid; E9PZZ1; -.
DR   OMA; ALAQWYD; -.
DR   OrthoDB; 1318335at2759; -.
DR   TreeFam; TF106398; -.
DR   BioGRID-ORCS; 230025; 2 hits in 75 CRISPR screens.
DR   ChiTaRS; Prdm13; mouse.
DR   PRO; PR:E9PZZ1; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; E9PZZ1; protein.
DR   Bgee; ENSMUSG00000040478; Expressed in retinal neural layer and 10 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042054; F:histone methyltransferase activity; IDA:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IDA:ARUK-UCL.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0022008; P:neurogenesis; IDA:MGI.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   CDD; cd19197; PR-SET_PRDM13; 1.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR044407; PRDM13_PR/SET.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Alternative splicing; DNA-binding; Metal-binding; Methyltransferase;
KW   Nucleus; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger.
FT   CHAIN           1..754
FT                   /note="PR domain zinc finger protein 13"
FT                   /id="PRO_0000416115"
FT   DOMAIN          39..160
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   ZN_FING         185..207
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         620..642
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         648..670
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         677..700
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          279..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..400
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..48
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_042506"
SQ   SEQUENCE   754 AA;  78705 MW;  82E2B2E3B109C37B CRC64;
     MPAHVTPRTE DARRGAGPSS ACGCSWFCHL RPVEDPASPS VCLAAVATMH GTSRTSATSV
     NADCCIPAGL RLGPVPGTFK LGKYLSDRRE PGPKKKVRMV RGELVDESGG SPLEWIGLIR
     AARNPQEQTL EAIADLPGGQ IFYRALRDVQ PGEELTVWYS NSLAQWFDIP TTATPTHDEK
     GEERYICWYC WRTFRYPNSL KAHLRFHCVL SGGGGRAFLP QEHAARPGAS PVAEGLGLPP
     KPTVPDLTAP VQAIALRPQA PAAQLAQACG ARESIKREAS LAPLATSPPP GKWGTPKKGK
     EQPDRAHSQF LGIVGGSSGG GGGLPFYPGV RSAFKPAGLA RAAAQSDPYR EEGGGKGPGL
     ALGRLLGGGR AGGRPGSGES PAGHHHHHHH AHHHHHHHPK CLLAGEPPPA GLPCPGALRA
     FPLLAGHPEE ASAFKHVERA PPAAATTSLP SARYAALPAP GLPVERCALQ PLDGGSLKAY
     PGGGGGGECS PLPAVMPAFT VYSGDLLYGP PAAYYPLKLH LGGLLKYPES ISYLSGPAAA
     AAAAAAAAAA AAAIGPAELG SLASIDREIA MHTQQLSEMA AGKSRARLDS GTLPPAVVAA
     TGPGGGGGGG SAAGKPKTGH LCLYCGKLYS RKYGLKIHMR THTGYKPLKC KVCLRPFGDP
     SNLNKHIRLH AEGNTPYRCE FCGKVLVRRR DLERHVKSRH PGQSLMAKAG DGPGPEPSYA
     LEPGDPKSED SDVDVCFTDD QSDPEAGGRG EHDS
 
 
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