PRDA1_ARATH
ID PRDA1_ARATH Reviewed; 397 AA.
AC Q1H5E9; Q8LCQ2; Q9LV67;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein PEP-RELATED DEVELOPMENT ARRESTED 1, chloroplastic {ECO:0000303|PubMed:24132784};
DE Short=AtPRDA1 {ECO:0000303|PubMed:24132784};
DE Flags: Precursor;
GN Name=PRDA1; OrderedLocusNames=At5g48470 {ECO:0000312|Araport:AT5G48470};
GN ORFNames=MJE7.11 {ECO:0000312|EMBL:BAA96967.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3] {ECO:0000312|EMBL:ABF58933.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INTERACTION WITH FSD2 AND MRL7, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, INDUCTION BY LIGHT, AND DISRUPTION PHENOTYPE.
RX PubMed=24132784; DOI=10.1093/pcp/pct148;
RA Qiao J., Li J., Chu W., Luo M.;
RT "PRDA1, a novel chloroplast nucleoid protein, is required for early
RT chloroplast development and is involved in the regulation of plastid gene
RT expression in Arabidopsis.";
RL Plant Cell Physiol. 54:2071-2084(2013).
CC -!- FUNCTION: Plays an essential role in early steps of chloroplast
CC development. May be involved in the redox control of plastid gene
CC expression by maintening the redox state around chloroplast nucleoids.
CC May positively regulate plastid-encoded RNA polymerase (PEP) activity,
CC through binding to FSD2. {ECO:0000269|PubMed:24132784}.
CC -!- SUBUNIT: Interacts with FSD2 and MRL7. {ECO:0000269|PubMed:24132784}.
CC -!- INTERACTION:
CC Q1H5E9; O80931: AS1; NbExp=3; IntAct=EBI-1998055, EBI-763232;
CC Q1H5E9; Q8RXD6: HUB1; NbExp=3; IntAct=EBI-1998055, EBI-2012188;
CC Q1H5E9; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-1998055, EBI-4426557;
CC Q1H5E9; Q5CCK4: VAL2; NbExp=3; IntAct=EBI-1998055, EBI-15193683;
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast stroma, chloroplast nucleoid
CC {ECO:0000269|PubMed:24132784}.
CC -!- TISSUE SPECIFICITY: Highly expressed in young leaves, shoots and
CC flowers. Expressed at low levels in stems and siliques.
CC {ECO:0000269|PubMed:24132784}.
CC -!- INDUCTION: Induced by light. {ECO:0000269|PubMed:24132784}.
CC -!- DISRUPTION PHENOTYPE: Seedling lethality due to deficiency in
CC chloroplast development. {ECO:0000269|PubMed:24132784}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA96967.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB020745; BAA96967.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95674.1; -; Genomic_DNA.
DR EMBL; BT025515; ABF58933.1; -; mRNA.
DR EMBL; AY086465; AAM63468.1; -; mRNA.
DR RefSeq; NP_568697.1; NM_124222.3.
DR AlphaFoldDB; Q1H5E9; -.
DR IntAct; Q1H5E9; 5.
DR STRING; 3702.AT5G48470.1; -.
DR PaxDb; Q1H5E9; -.
DR PRIDE; Q1H5E9; -.
DR ProteomicsDB; 226496; -.
DR EnsemblPlants; AT5G48470.1; AT5G48470.1; AT5G48470.
DR GeneID; 834902; -.
DR Gramene; AT5G48470.1; AT5G48470.1; AT5G48470.
DR KEGG; ath:AT5G48470; -.
DR Araport; AT5G48470; -.
DR TAIR; locus:2165986; AT5G48470.
DR eggNOG; ENOG502QRV4; Eukaryota.
DR HOGENOM; CLU_046485_0_0_1; -.
DR InParanoid; Q1H5E9; -.
DR OMA; LEWVHQN; -.
DR OrthoDB; 809451at2759; -.
DR PhylomeDB; Q1H5E9; -.
DR PRO; PR:Q1H5E9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q1H5E9; baseline and differential.
DR GO; GO:0042644; C:chloroplast nucleoid; IDA:UniProtKB.
DR GO; GO:0009658; P:chloroplast organization; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR InterPro; IPR038961; PRDA1.
DR PANTHER; PTHR37262; PTHR37262; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Plastid; Reference proteome; Transit peptide.
FT TRANSIT 1..52
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 53..397
FT /note="Protein PEP-RELATED DEVELOPMENT ARRESTED 1,
FT chloroplastic"
FT /id="PRO_0000439384"
FT REGION 315..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 326
FT /note="D -> S (in Ref. 4; AAM63468)"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="N -> K (in Ref. 4; AAM63468)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 397 AA; 44013 MW; 628FF3FDE1B3B018 CRC64;
MLQSIHLRFS STPSPSKRES LIIPSVICSF PFTSSSFRPK QTQKLKRLVQ FCAPYEVGGG
YTDEELFERY GTQQNQTNVK DKLDPAEYEA LLKGGEQVTS VLEEMITLLE DMKMNEASEN
VAVELAAQGV IGKRVDEMES GFMMALDYMI QLADKDQDEK RKSLLEVVKE TVLSHLTKKC
PPHVQVIGLL CRTPKKESRH ELLRRVAAGG GAFESENGTK LHIPGANLND IANQADDLLE
TMETRPAIPD RKLLARLVLI REEARNMMGG GILDERNDRG FTTLPESEVN FLAKLVALKP
GKTVQQMIQN VMQGKDEGAD NLSKEDDSST EGRKPSGLNG RGSVTGRKPL PVRPGMFLET
VTKVLGSIYS GNASGITAQH LEWVHQKTLQ VLEEIAY
