ID   ATG13_PICAN             Reviewed;         701 AA.
AC   A7KAJ8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Autophagy-related protein 13;
GN   Name=ATG13;
OS   Pichia angusta (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=870730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL
RC   Y-5445;
RX   PubMed=17204848; DOI=10.4161/auto.3595;
RA   Meijer W.H., van der Klei I.J., Veenhuis M., Kiel J.A.K.W.;
RT   "ATG genes involved in non-selective autophagy are conserved from yeast to
RT   man, but the selective Cvt and pexophagy pathways also require organism-
RT   specific genes.";
RL   Autophagy 3:106-116(2007).
CC   -!- FUNCTION: Activates the ATG1 kinase in a nutritional condition
CC       dependent manner through the TOR pathway, leading to autophagy. Also
CC       involved in cytoplasm to vacuole transport (Cvt) and more specifically
CC       in Cvt vesicle formation. Seems to play a role in the switching
CC       machinery regulating the conversion between the Cvt pathway and
CC       autophagy. Finally, ATG13 is also required for glycogen storage during
CC       stationary phase (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:17204848}.
CC   -!- SUBUNIT: Interacts with ATG1 to form the ATG1-ATG13 kinase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06628}.
CC       Preautophagosomal structure {ECO:0000250|UniProtKB:Q06628}.
CC   -!- SIMILARITY: Belongs to the ATG13 family. Fungi subfamily.
CC       {ECO:0000305}.
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DR   EMBL; EF107720; ABO31058.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7KAJ8; -.
DR   SMR; A7KAJ8; -.
DR   PRIDE; A7KAJ8; -.
DR   PhylomeDB; A7KAJ8; -.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IEA:InterPro.
DR   GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR   GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR040182; ATG13.
DR   InterPro; IPR018731; Atg13_N.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   PANTHER; PTHR13430; PTHR13430; 1.
DR   Pfam; PF10033; ATG13; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Protein transport; Transport.
FT   CHAIN           1..701
FT                   /note="Autophagy-related protein 13"
FT                   /id="PRO_0000317949"
FT   REGION          319..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          577..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..636
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..665
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   701 AA;  77933 MW;  57BD2B86E7AC39AA CRC64;
     MSSARRPSKL LSEKQSDKLA QIIQNFFLKA AHVIFHFRVA FPSVVLQPDD SYGAMGDTFS
     QSKYNNRWFN LDLGNYEIPR TELSLWRNKD ILSLPPLVLE TFLDLRGLSS NQTLMLDDVI
     VKTSKKSEIV LERWLIEFDL STFDNEVMEF PSIYKKIIIL FRSLYLLAGL LPSYRLRDKL
     VKSKSKNSAI HVSCRILDGS KPITSKGRIG LSKKLLSEEE HTSSKKLQPV LTPIGALRVS
     VSYRTNCNFQ VSDTEEALSS QFMLDHLPSV RTNYDSDGNS LTSPMDYLQN RVSSASIHWS
     DQSPRRRSST RSVQLFKVGS INSSSSPPPG ATQSNQSVSS FSTSKPIPVT LNKTNSSASL
     VPILRQNKDS LPKSIGSMVQ NQMQETGHQV SSNSRRFSSS FGSRFRTVSS RNNSLDGQLV
     VANQPFSTPS NNPILHNFRS RNKSPSVSST ELGPSSSIYM DDDLDSFMKM LDSKPDLRFP
     SNSPSVYEDP LANFKTFQKS NDFLALEQQQ HGSPTSNQIM IHSQSQTSQS QVFKRTVFSD
     RSRRGSVSSN YSPSSQALRP GASAPMVTPS VTYGKFHASS GSPSNSSLAQ YLRHNSSPPA
     SATAVATVHN SLRRLTSSSQ RTNTNSTNSS TRPVNPELLK LKSFNEDVFE SDDDEHDEHS
     PRSTDTKSRN TGPSSGHAED DEDDLLFAMS DMTLAKNNQE F