ID   PRDC1_XENLA             Reviewed;         224 AA.
AC   Q6DCP3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Phosphoribosyltransferase domain-containing protein 1;
GN   Name=prtfdc1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved active site Asp and is not expected to
CC       have phosphoribosyltransferase activity. {ECO:0000305}.
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DR   EMBL; BC077960; AAH77960.1; -; mRNA.
DR   RefSeq; NP_001087060.1; NM_001093591.1.
DR   AlphaFoldDB; Q6DCP3; -.
DR   SMR; Q6DCP3; -.
DR   DNASU; 446895; -.
DR   GeneID; 446895; -.
DR   KEGG; xla:446895; -.
DR   CTD; 446895; -.
DR   Xenbase; XB-GENE-942169; prtfdc1.L.
DR   OMA; IEFMAVS; -.
DR   OrthoDB; 1537610at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 446895; Expressed in pancreas and 20 other tissues.
DR   GO; GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:InterPro.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR005904; Hxn_phspho_trans.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01203; HGPRTase; 1.
PE   2: Evidence at transcript level;
KW   Magnesium; Metal-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..224
FT                   /note="Phosphoribosyltransferase domain-containing protein
FT                   1"
FT                   /id="PRO_0000318177"
FT   BINDING         140..148
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         141
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         193..194
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         200
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         200
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  25875 MW;  7361630499011672 CRC64;
     MTEKSISPSR DIGVVVPDNW TGYELDVFSL PNHYCEDLEC VFIPHGVIVD RTERIAHDIM
     RDIGDNHITV LCVLKGGYRF CTDLVEHIKN LSRNSERFIS MRVDFIRLKC YRNDQCMDEM
     QIIGGEDLAK LSGKNVLIVE DIINTGRTMT ALLNQLEKYK PKMVKVASLL VKRSASSNQY
     RPDYTGFEIP NKFVVGYALD YNEYFRDLHH ICIINEKGKN KYKV