ID   PRDC1_XENTR             Reviewed;         224 AA.
AC   A4II60;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Phosphoribosyltransferase domain-containing protein 1;
GN   Name=prtfdc1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved active site Asp and is not expected to
CC       have phosphoribosyltransferase activity. {ECO:0000305}.
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DR   EMBL; BC135868; AAI35869.1; -; mRNA.
DR   RefSeq; NP_001096362.1; NM_001102892.1.
DR   RefSeq; XP_017950000.1; XM_018094511.1.
DR   AlphaFoldDB; A4II60; -.
DR   SMR; A4II60; -.
DR   STRING; 8364.ENSXETP00000063886; -.
DR   PaxDb; A4II60; -.
DR   Ensembl; ENSXETT00000066094; ENSXETP00000063886; ENSXETG00000005902.
DR   GeneID; 100124954; -.
DR   KEGG; xtr:100124954; -.
DR   CTD; 56952; -.
DR   Xenbase; XB-GENE-942165; prtfdc1.
DR   eggNOG; KOG3367; Eukaryota.
DR   HOGENOM; CLU_073615_3_0_1; -.
DR   InParanoid; A4II60; -.
DR   OrthoDB; 1537610at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005902; Expressed in testis and 13 other tissues.
DR   ExpressionAtlas; A4II60; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:InterPro.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR005904; Hxn_phspho_trans.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01203; HGPRTase; 1.
PE   2: Evidence at transcript level;
KW   Magnesium; Metal-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..224
FT                   /note="Phosphoribosyltransferase domain-containing protein
FT                   1"
FT                   /id="PRO_0000318178"
FT   BINDING         140..148
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         141
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         193..194
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         200
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000250"
FT   BINDING         200
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  25757 MW;  A8EC010C882B3FEC CRC64;
     MTEKSICPSR DNGVVIPDNW TGYDLDVFSL PNHYCEDLEC VFIPHGVIVD RTERIANDIM
     RDIGDNHITV LCVLKGGYRF CTDLVEHIKN LSRNSERFIS MRVDFIRLKC YCNDQCMDEL
     QILGGEDLAK LSGKNVLIVE DIINTGRTMT ALLSQLEKYK PKMVKVASLL VKRSASSNQY
     RPDYTGFEIP NKFVVGYALD YNEYFRDLHH ICVINEKGKN KYKV