PRDE1_CAEEL
ID PRDE1_CAEEL Reviewed; 526 AA.
AC O17828;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=piRNA biogenesis factor prde-1 {ECO:0000305|PubMed:25373775};
DE AltName: Full=piRNA silencing defective protein 1 {ECO:0000305|PubMed:24696457};
GN Name=prde-1 {ECO:0000312|WormBase:F21A3.5};
GN ORFNames=F21A3.5 {ECO:0000312|WormBase:F21A3.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=25373775; DOI=10.1016/j.devcel.2014.09.015;
RA Kasper D.M., Wang G., Gardner K.E., Johnstone T.G., Reinke V.;
RT "The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally
RT required for piRNA abundance.";
RL Dev. Cell 31:145-158(2014).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=24696457; DOI=10.1101/gad.238105.114;
RA Weick E.M., Sarkies P., Silva N., Chen R.A., Moss S.M., Cording A.C.,
RA Ahringer J., Martinez-Perez E., Miska E.A.;
RT "PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-
RT dependent piRNAs in C. elegans.";
RL Genes Dev. 28:783-796(2014).
CC -!- FUNCTION: Nuclear factor required for the production of piwi-
CC interacting RNA (piRNA) precursors (PubMed:24696457). Specifically
CC required for piRNAs produced from loci associated with the Ruby motif
CC (PubMed:24696457). Promotes binding of the transcription factor snpc-4
CC at piRNA genomic clusters (PubMed:25373775). Required for normal
CC fertility (PubMed:24696457). {ECO:0000269|PubMed:24696457,
CC ECO:0000269|PubMed:25373775}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24696457,
CC ECO:0000269|PubMed:25373775}. Chromosome {ECO:0000269|PubMed:24696457}.
CC Note=Concentrated in nuclear foci of pachytene germ cells
CC (PubMed:25373775, PubMed:24696457). Colocalizes with snpc-4 in nuclear
CC foci in a mutually dependent fashion (PubMed:25373775).
CC {ECO:0000269|PubMed:24696457, ECO:0000269|PubMed:25373775}.
CC -!- TISSUE SPECIFICITY: Expressed in male and female germ cells.
CC {ECO:0000269|PubMed:24696457}.
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DR EMBL; BX284605; CAB04156.3; -; Genomic_DNA.
DR RefSeq; NP_506866.3; NM_074465.3.
DR AlphaFoldDB; O17828; -.
DR SMR; O17828; -.
DR STRING; 6239.F21A3.5; -.
DR EPD; O17828; -.
DR PaxDb; O17828; -.
DR EnsemblMetazoa; F21A3.5.1; F21A3.5.1; WBGene00008995.
DR EnsemblMetazoa; F21A3.5.2; F21A3.5.2; WBGene00008995.
DR GeneID; 184750; -.
DR KEGG; cel:CELE_F21A3.5; -.
DR UCSC; F21A3.5; c. elegans.
DR CTD; 184750; -.
DR WormBase; F21A3.5; CE44026; WBGene00008995; prde-1.
DR eggNOG; KOG1164; Eukaryota.
DR HOGENOM; CLU_555803_0_0_1; -.
DR InParanoid; O17828; -.
DR OMA; CPKGPRA; -.
DR OrthoDB; 1238924at2759; -.
DR PhylomeDB; O17828; -.
DR Reactome; R-CEL-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-CEL-196299; Beta-catenin phosphorylation cascade.
DR PRO; PR:O17828; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00008995; Expressed in tail neuron (C elegans) and 7 other tissues.
DR GO; GO:0030849; C:autosome; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:1990511; P:piRNA biosynthetic process; IMP:WormBase.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..526
FT /note="piRNA biogenesis factor prde-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000433369"
FT REGION 436..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 61045 MW; 3A02A1890EC538C3 CRC64;
MNRNRKGHDL ENIEHRFTDE DLAGLKEQKL FNGKWIILEK KEKRGAAYCY LVCDKPCKKF
GILYLEIGED NVTTIANQVD FYHQQSSLGY SHRFSALIDA GIINNHVFFM VVRIRAGPTL
HDLLKCLSSD KMSVTTASFL AVDMISAIEI LSASGWVLRN FDSKQWMLDI KTRQFYLADA
TDITVSSDKR HRAIDEIHLR TAESIDLHWK TGDLIYAPRS FVDRDQSHRM TELDMMEMML
YVLYDWTHGK LPWKSSKSRE RIMEMKELFI ENLQKEPEET NKVEQQIDVD VWFDIALRNF
AKHLKVAKEE QEKLEKLPVR GGAWCPKGPR AGAQISTVNY RGIIDDFYKI VCSGRPAWAL
HWRDVMLDWD RKLENTPETS KMFEAYEKHQ RSLEISEEWE RLQATREHYT VMKNHTETEM
AKNQAAIVEY LMPEEEAKEE PIDKKKDPEE EAAAAVVGKK RRGRKPKKKD DPKMELKDEV
KDLKDFVVEE STSASSSAPK KRPCCSSGSP LKSSGGRRRG CEIRRK
