PRDM4_RAT
ID PRDM4_RAT Reviewed; 798 AA.
AC Q9QZP2;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=PR domain zinc finger protein 4;
DE EC=2.1.1.-;
DE AltName: Full=PR domain-containing protein 4;
GN Name=Prdm4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10485890; DOI=10.1073/pnas.96.19.10705;
RA Chittka A., Chao M.V.;
RT "Identification of a zinc finger protein whose subcellular distribution is
RT regulated by serum and nerve growth factor.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:10705-10710(1999).
CC -!- FUNCTION: May function as a transcription factor involved in cell
CC differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR EMBL; AF176023; AAD52971.1; -; mRNA.
DR RefSeq; NP_579846.1; NM_133312.1.
DR AlphaFoldDB; Q9QZP2; -.
DR SMR; Q9QZP2; -.
DR STRING; 10116.ENSRNOP00000006886; -.
DR PaxDb; Q9QZP2; -.
DR PRIDE; Q9QZP2; -.
DR GeneID; 170820; -.
DR KEGG; rno:170820; -.
DR UCSC; RGD:619929; rat.
DR CTD; 11108; -.
DR RGD; 619929; Prdm4.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; KOG2461; Eukaryota.
DR InParanoid; Q9QZP2; -.
DR PhylomeDB; Q9QZP2; -.
DR PRO; PR:Q9QZP2; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0035097; C:histone methyltransferase complex; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005123; F:death receptor binding; IPI:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:1990226; F:histone methyltransferase binding; ISO:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
DR GO; GO:0031670; P:cellular response to nutrient; IEP:RGD.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0030308; P:negative regulation of cell growth; IDA:RGD.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; IMP:ParkinsonsUK-UCL.
DR GO; GO:2000736; P:regulation of stem cell differentiation; IMP:ParkinsonsUK-UCL.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd19189; PR-SET_PRDM4; 1.
DR Gene3D; 2.170.270.10; -; 1.
DR InterPro; IPR017124; PRDM4.
DR InterPro; IPR044404; PRDM4_PR/SET.
DR InterPro; IPR041493; PRDM4_Znf_knuckle.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF18445; zf_PR_Knuckle; 1.
DR PIRSF; PIRSF037161; PRDM4; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Methyltransferase; Nucleus; Reference proteome;
KW Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW Transferase; Zinc; Zinc-finger.
FT CHAIN 1..798
FT /note="PR domain zinc finger protein 4"
FT /id="PRO_0000230793"
FT DOMAIN 408..525
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT ZN_FING 586..608
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 614..636
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 642..664
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 670..692
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 698..720
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 726..747
FT /note="C2H2-type 6; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 750..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 87392 MW; 7E409426E6B56F90 CRC64;
MNDMNLSPVG MEQLSSSSVS NALPVSGSHL GLAASPSHSA IPAPGLPVAI PNLGPSLSSL
PSALSLMLPM GIGDRGVMCG LPERNYTLPP PPYPHLESSY FRTILPGILS YLADRPPPQY
IHPNSINVDG NTALSITNNP SALDPYQANG NVGLELGIVS IDSRSVNTHG AQSLHPNDGH
EVALDTTITM ENVSRVTSPI STDGMAEELT MDGVTGEHSQ IPNGSRSHEP LSVDSVSNNL
TADTVGHGGV IPIHGNGLEL PVVMETDHIA NRVNGISDSV LSDSIHTVAM STNSVSVALS
TSHNFASLES VSLQEVGLSL EPVAVSSITQ EVAMGTGHVD VSSDSLSFVP SSLQMEDSNS
NKENMATLFT IWCTLCDRAY PSDCPDHGPV TFVPDTPIES RARLSLPKQL VLRQSIVGTD
VGVWTAETIP VRTCFGPLIG QQSHSMEVAE WTDKAVSHVW KIYHNGVLEF CIITTDENEC
NWMMFVRKAR NREEQNLVAY PHDGKIYFCT SQDIPPENEL LFYYSRDYAQ QIGVPEHPDV
HLCNCGKECS SYSEFKAHLT SHIHNHLPSQ GHSSSHGPSH SKERKWKCSM CPQAFISPSK
LHVHFMGHMG MKPHKCDFCS KAFSDPSNLR THLKIHTGQK NYRCTLCDKS FTQKAHLESH
MVIHTGEKNL KCDYCDKLFM RRQDLKQHVL IHTQERQIKC PKCDKLFLRT NHLKKHLNSH
EGRRDYVCEK CTKAYLTKYH LTRHLKACKE PASSSSAQDD EDEDGDSGED GLPGSMTTEG
CRMSSAVYSA DESLSAHK
