ATG13_VANPO
ID ATG13_VANPO Reviewed; 654 AA.
AC A7TTE2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Autophagy-related protein 13;
GN Name=ATG13; ORFNames=Kpol_219p5;
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC Y-8283 / UCD 57-17;
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- FUNCTION: Activates the ATG1 kinase in a nutritional condition
CC dependent manner through the TOR pathway, leading to autophagy. Also
CC involved in cytoplasm to vacuole transport (Cvt) and more specifically
CC in Cvt vesicle formation. Seems to play a role in the switching
CC machinery regulating the conversion between the Cvt pathway and
CC autophagy. Finally, ATG13 is also required for glycogen storage during
CC stationary phase (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ATG1 to form the ATG1-ATG13 kinase complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06628}.
CC Preautophagosomal structure {ECO:0000250|UniProtKB:Q06628}.
CC -!- SIMILARITY: Belongs to the ATG13 family. Fungi subfamily.
CC {ECO:0000305}.
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DR EMBL; DS480562; EDO14469.1; -; Genomic_DNA.
DR RefSeq; XP_001642327.1; XM_001642277.1.
DR AlphaFoldDB; A7TTE2; -.
DR SMR; A7TTE2; -.
DR STRING; 436907.A7TTE2; -.
DR EnsemblFungi; EDO14469; EDO14469; Kpol_219p5.
DR GeneID; 5542460; -.
DR KEGG; vpo:Kpol_219p5; -.
DR eggNOG; KOG4573; Eukaryota.
DR HOGENOM; CLU_411076_0_0_1; -.
DR InParanoid; A7TTE2; -.
DR OMA; YAKLHRP; -.
DR OrthoDB; 490734at2759; -.
DR PhylomeDB; A7TTE2; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:1990316; C:Atg1/ULK1 kinase complex; IEA:InterPro.
DR GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR040182; ATG13.
DR InterPro; IPR018731; Atg13_N.
DR InterPro; IPR036570; HORMA_dom_sf.
DR PANTHER; PTHR13430; PTHR13430; 1.
DR Pfam; PF10033; ATG13; 1.
PE 3: Inferred from homology;
KW Autophagy; Cytoplasm; Protein transport; Reference proteome; Transport.
FT CHAIN 1..654
FT /note="Autophagy-related protein 13"
FT /id="PRO_0000317953"
SQ SEQUENCE 654 AA; 73393 MW; 11127FDB7951C0DA CRC64;
MAPHNCDREL IDLIHNFFLR STLLICSSKL NKNQHLLEEI QKFDSDLNEK PDLPKTINEW
FHDENERNLP PLVIETLLDL KKLSPNHFVT LRDDDGNVWN VCKGTKKSEI VLERWLIELD
NTSAAFQSYR GTIDSTGEIR KQIVLLARYL VTLIQILPSN ELEENLTKNS TNLILSLKRK
VIDGSKPILS KGRIGLSKPI ISTYSNVINE RNIPPHLEQR KITPVYTPLG LLRISVSFRH
DCRFEVNQST DSSDNVASNT TNIHQHLEPL HNKNYTNTSL SISPHSHIAL ASSSERNSIG
KKDLNSKPIH PFKTGSVGSC TINQSQAMIR TTSNPSVIAT LRAQRSRNDS ISCQSQLEDI
QLESTSVGSG SKYSSSFGRI RRHSSVKSSE NVEKPIRLVK QSNAPTDDLL DFVKMMDEKQ
ELRITKCNIS SNNADISNSI LRFQKLKSSN EILSEDLSMS VSLEGVNASM HRRSSVSHSP
IPSVSPPVQY PSIPSRLSKT NLQEQDTFKT AVVSRRNSVE KSKINISQPK TTGRIENELV
DKPLFNEEHE SKGEELLASG IIGPSFKRST SPHSIESVSS LISKTKIAFQ QPSYYSHPTT
AAVPAYAKLH RPSVLSTDVL SEDQNKKVVQ DLNNNKDEDD ELLFFMSDMN LSKI