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ATG13_VANPO
ID   ATG13_VANPO             Reviewed;         654 AA.
AC   A7TTE2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Autophagy-related protein 13;
GN   Name=ATG13; ORFNames=Kpol_219p5;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Activates the ATG1 kinase in a nutritional condition
CC       dependent manner through the TOR pathway, leading to autophagy. Also
CC       involved in cytoplasm to vacuole transport (Cvt) and more specifically
CC       in Cvt vesicle formation. Seems to play a role in the switching
CC       machinery regulating the conversion between the Cvt pathway and
CC       autophagy. Finally, ATG13 is also required for glycogen storage during
CC       stationary phase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ATG1 to form the ATG1-ATG13 kinase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06628}.
CC       Preautophagosomal structure {ECO:0000250|UniProtKB:Q06628}.
CC   -!- SIMILARITY: Belongs to the ATG13 family. Fungi subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS480562; EDO14469.1; -; Genomic_DNA.
DR   RefSeq; XP_001642327.1; XM_001642277.1.
DR   AlphaFoldDB; A7TTE2; -.
DR   SMR; A7TTE2; -.
DR   STRING; 436907.A7TTE2; -.
DR   EnsemblFungi; EDO14469; EDO14469; Kpol_219p5.
DR   GeneID; 5542460; -.
DR   KEGG; vpo:Kpol_219p5; -.
DR   eggNOG; KOG4573; Eukaryota.
DR   HOGENOM; CLU_411076_0_0_1; -.
DR   InParanoid; A7TTE2; -.
DR   OMA; YAKLHRP; -.
DR   OrthoDB; 490734at2759; -.
DR   PhylomeDB; A7TTE2; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IEA:InterPro.
DR   GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR   GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR040182; ATG13.
DR   InterPro; IPR018731; Atg13_N.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   PANTHER; PTHR13430; PTHR13430; 1.
DR   Pfam; PF10033; ATG13; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..654
FT                   /note="Autophagy-related protein 13"
FT                   /id="PRO_0000317953"
SQ   SEQUENCE   654 AA;  73393 MW;  11127FDB7951C0DA CRC64;
     MAPHNCDREL IDLIHNFFLR STLLICSSKL NKNQHLLEEI QKFDSDLNEK PDLPKTINEW
     FHDENERNLP PLVIETLLDL KKLSPNHFVT LRDDDGNVWN VCKGTKKSEI VLERWLIELD
     NTSAAFQSYR GTIDSTGEIR KQIVLLARYL VTLIQILPSN ELEENLTKNS TNLILSLKRK
     VIDGSKPILS KGRIGLSKPI ISTYSNVINE RNIPPHLEQR KITPVYTPLG LLRISVSFRH
     DCRFEVNQST DSSDNVASNT TNIHQHLEPL HNKNYTNTSL SISPHSHIAL ASSSERNSIG
     KKDLNSKPIH PFKTGSVGSC TINQSQAMIR TTSNPSVIAT LRAQRSRNDS ISCQSQLEDI
     QLESTSVGSG SKYSSSFGRI RRHSSVKSSE NVEKPIRLVK QSNAPTDDLL DFVKMMDEKQ
     ELRITKCNIS SNNADISNSI LRFQKLKSSN EILSEDLSMS VSLEGVNASM HRRSSVSHSP
     IPSVSPPVQY PSIPSRLSKT NLQEQDTFKT AVVSRRNSVE KSKINISQPK TTGRIENELV
     DKPLFNEEHE SKGEELLASG IIGPSFKRST SPHSIESVSS LISKTKIAFQ QPSYYSHPTT
     AAVPAYAKLH RPSVLSTDVL SEDQNKKVVQ DLNNNKDEDD ELLFFMSDMN LSKI
 
 
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