ID   ATG13_XENTR             Reviewed;         510 AA.
AC   A4IIM9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Autophagy-related protein 13;
GN   Name=atg13;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Autophagy factor required for autophagosome formation. Target
CC       of the TOR kinase signaling pathway that regulates autophagy through
CC       the control of the phosphorylation status of ATG13 and ULK1, and the
CC       regulation of the ATG13-ULK1-RB1CC1 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q91YI1}. Preautophagosomal structure
CC       {ECO:0000250|UniProtKB:Q91YI1}. Note=Under starvation conditions, is
CC       localized to puncate structures primarily representing the isolation
CC       membrane that sequesters a portion of the cytoplasm resulting in the
CC       formation of an autophagosome. {ECO:0000250|UniProtKB:Q91YI1}.
CC   -!- PTM: Phosphorylated under nutrient-rich conditions; dephosphorylated
CC       during starvation or following treatment with rapamycin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG13 family. Metazoan subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC136085; AAI36086.1; -; mRNA.
DR   RefSeq; NP_001096420.1; NM_001102950.1.
DR   AlphaFoldDB; A4IIM9; -.
DR   SMR; A4IIM9; -.
DR   STRING; 8364.ENSXETP00000004250; -.
DR   DNASU; 100125026; -.
DR   Ensembl; ENSXETT00000004248; ENSXETP00000004248; ENSXETG00000001983.
DR   GeneID; 100125026; -.
DR   KEGG; xtr:100125026; -.
DR   CTD; 9776; -.
DR   Xenbase; XB-GENE-960599; atg13.
DR   eggNOG; KOG3874; Eukaryota.
DR   HOGENOM; CLU_036365_0_0_1; -.
DR   InParanoid; A4IIM9; -.
DR   OrthoDB; 926357at2759; -.
DR   Reactome; R-XTR-1632852; Macroautophagy.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001983; Expressed in skeletal muscle tissue and 23 other tissues.
DR   ExpressionAtlas; A4IIM9; baseline and differential.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0000423; P:mitophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IBA:GO_Central.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR040182; ATG13.
DR   InterPro; IPR018731; Atg13_N.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   PANTHER; PTHR13430; PTHR13430; 1.
DR   Pfam; PF10033; ATG13; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Reference proteome.
FT   CHAIN           1..510
FT                   /note="Autophagy-related protein 13"
FT                   /id="PRO_0000345155"
FT   REGION          295..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  55810 MW;  B3E6FDD8BC11D642 CRC64;
     MDTDLSPQDR KDLDKFIKFF ALKSVQVIVQ ARLGDKICTR SSSSPTGSDW FNLAIKDIPE
     VTHEAKKALS GQLPAVGRSM CVEISLKTSE GDSMELEVWC LEMNEKCDRD IKVSYTVYNR
     LSLLLKSLLA VTRVTPAYRL SRKQGHEYVI LYRIYFGDVQ LLGLKEGFQA VRVGTVGTPV
     GTLTLTCAYR TNLAFMSTRQ YEWTQPIMGI IIDHFVDRPF PSTSHMHPCN YRGAEEQVLT
     YPAVEESQEV CTTSFSTSPP SQLCSSRLSY QPAVPGAGPS ELGYPVALAT GVSAGHPHQM
     MAPGKESGLP AVSVQPAHGN QAEHDRTLSV SPANVAGTTS SSEEADSPSG SSTTGAKSSP
     NKNTHVLFTR KVGAFVDKPS PQVTYASTDI PFAVFVPKLA DNEDTDPMVV YPETPEEESP
     EARSLHSSCS SSGTPQDDFV MVDFKPAFSK DDLPMDVGTF YREFQNPPQL SSLSIDIAVQ
     SMAEDLDSLP EKLAMHEKNM KEFDAFVDSL