PRE1_ARATH
ID PRE1_ARATH Reviewed; 92 AA.
AC Q9FLE9;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transcription factor PRE1;
DE AltName: Full=Basic helix-loop-helix protein 136;
DE Short=AtbHLH136;
DE Short=bHLH 136;
DE AltName: Full=Protein BANQUO 1;
DE AltName: Full=Protein PACLOBUTRAZOL RESISTANCE 1;
DE AltName: Full=bHLH transcription factor bHLH136;
GN Name=PRE1; Synonyms=BHLH136, BNQ1; OrderedLocusNames=At5g39860;
GN ORFNames=MYH19.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY GIBBERELLIN.
RX PubMed=16527868; DOI=10.1093/pcp/pcj026;
RA Lee S., Lee S., Yang K.Y., Kim Y.M., Park S.Y., Kim S.Y., Soh M.S.;
RT "Overexpression of PRE1 and its homologous genes activates gibberellin-
RT dependent responses in Arabidopsis thaliana.";
RL Plant Cell Physiol. 47:591-600(2006).
RN [6]
RP FUNCTION, INTERACTION WITH IBH1, AND INDUCTION BY EPIBRASSINOLIDE.
RX PubMed=20009022; DOI=10.1105/tpc.109.070441;
RA Zhang L.Y., Bai M.Y., Wu J., Zhu J.Y., Wang H., Zhang Z., Wang W., Sun Y.,
RA Zhao J., Sun X., Yang H., Xu Y., Kim S.H., Fujioka S., Lin W.H., Chong K.,
RA Lu T., Wang Z.Y.;
RT "Antagonistic HLH/bHLH transcription factors mediate brassinosteroid
RT regulation of cell elongation and plant development in rice and
RT Arabidopsis.";
RL Plant Cell 21:3767-3780(2009).
RN [7]
RP FUNCTION, AND INTERACTION WITH HFR1.
RX PubMed=20305124; DOI=10.1105/tpc.109.065946;
RA Mara C.D., Huang T., Irish V.F.;
RT "The Arabidopsis floral homeotic proteins APETALA3 and PISTILLATA
RT negatively regulate the BANQUO genes implicated in light signaling.";
RL Plant Cell 22:690-702(2010).
RN [8]
RP FUNCTION, AND INTERACTION WITH IBH1.
RX PubMed=23161888; DOI=10.1105/tpc.112.105023;
RA Ikeda M., Fujiwara S., Mitsuda N., Ohme-Takagi M.;
RT "A triantagonistic basic helix-loop-helix system regulates cell elongation
RT in Arabidopsis.";
RL Plant Cell 24:4483-4497(2012).
RN [9]
RP FUNCTION, AND INTERACTION WITH IBH1.
RX PubMed=23221598; DOI=10.1105/tpc.112.105163;
RA Bai M.Y., Fan M., Oh E., Wang Z.Y.;
RT "A triple helix-loop-helix/basic helix-loop-helix cascade controls cell
RT elongation downstream of multiple hormonal and environmental signaling
RT pathways in Arabidopsis.";
RL Plant Cell 24:4917-4929(2012).
CC -!- FUNCTION: Atypical and probable non DNA-binding bHLH transcription
CC factor that integrates multiple signaling pathways to regulate cell
CC elongation and plant development. Binds IBH1, forming a pair of
CC antagonistic bHLH transcription factors that function downstream of
CC BZR1 to mediate brassinosteroid regulation of cell elongation.
CC Regulates light responses by binding and inhibiting the activity of the
CC bHLH transcription factor HFR1, a critical regulator of light signaling
CC and shade avoidance. May have a regulatory role in various aspects of
CC gibberellin-dependent growth and development.
CC {ECO:0000269|PubMed:16527868, ECO:0000269|PubMed:20009022,
CC ECO:0000269|PubMed:20305124, ECO:0000269|PubMed:23161888,
CC ECO:0000269|PubMed:23221598}.
CC -!- SUBUNIT: Interacts with IBH1 and HFR1. {ECO:0000269|PubMed:20009022,
CC ECO:0000269|PubMed:20305124, ECO:0000269|PubMed:23161888,
CC ECO:0000269|PubMed:23221598}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:16527868}.
CC -!- INDUCTION: By gibberellin and epibrassinolide.
CC {ECO:0000269|PubMed:16527868, ECO:0000269|PubMed:20009022}.
CC -!- MISCELLANEOUS: Gain-of-function mutants (T-DNA tagging) show long
CC hypocotyls, pale green and slightly narrow leaves, elongated petioles
CC and early flowering. They are not sensitive to the gibberellin
CC inhibitor paclobutrazol during seed germination (PubMed:16527868,
CC PubMed:20009022, PubMed:23221598). {ECO:0000305|PubMed:16527868,
CC ECO:0000305|PubMed:20009022, ECO:0000305|PubMed:23221598}.
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DR EMBL; AB010077; BAB10210.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94484.1; -; Genomic_DNA.
DR EMBL; AY088246; AAM65786.1; -; mRNA.
DR RefSeq; NP_198802.1; NM_123349.3.
DR AlphaFoldDB; Q9FLE9; -.
DR SMR; Q9FLE9; -.
DR BioGRID; 19233; 9.
DR IntAct; Q9FLE9; 7.
DR STRING; 3702.AT5G39860.1; -.
DR iPTMnet; Q9FLE9; -.
DR PaxDb; Q9FLE9; -.
DR PRIDE; Q9FLE9; -.
DR ProteomicsDB; 234803; -.
DR EnsemblPlants; AT5G39860.1; AT5G39860.1; AT5G39860.
DR GeneID; 833982; -.
DR Gramene; AT5G39860.1; AT5G39860.1; AT5G39860.
DR KEGG; ath:AT5G39860; -.
DR Araport; AT5G39860; -.
DR TAIR; locus:2178002; AT5G39860.
DR eggNOG; ENOG502S648; Eukaryota.
DR HOGENOM; CLU_183267_0_0_1; -.
DR InParanoid; Q9FLE9; -.
DR OMA; PRISDNQ; -.
DR OrthoDB; 1589357at2759; -.
DR PhylomeDB; Q9FLE9; -.
DR PRO; PR:Q9FLE9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FLE9; baseline and differential.
DR Genevisible; Q9FLE9; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009640; P:photomorphogenesis; IMP:TAIR.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR GO; GO:0009741; P:response to brassinosteroid; IEP:TAIR.
DR GO; GO:0009826; P:unidimensional cell growth; IMP:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR044293; PRE.
DR PANTHER; PTHR46446; PTHR46446; 1.
DR Pfam; PF00010; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Brassinosteroid signaling pathway; Gibberellin signaling pathway;
KW Growth regulation; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..92
FT /note="Transcription factor PRE1"
FT /id="PRO_0000429083"
FT DOMAIN 4..59
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 92 AA; 10515 MW; 172F1DA7A18857C2 CRC64;
MSNRRSRQSS SAPRISDNQM IDLVSKLRQI LPEIGQRRRS DKASASKVLQ ETCNYIRNLN
REVDNLSERL SQLLESVDED SPEAAVIRSL LM
