PRE2_STAAM
ID PRE2_STAAM Reviewed; 420 AA.
AC P0A0C5; P22490; Q52091;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Plasmid recombination enzyme type 2;
DE AltName: Full=Mobilization protein;
DE AltName: Full=Plasmid recombinase;
GN Name=pre; Synonyms=mob; OrderedLocusNames=SAV0031;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: The interaction of the RSA site and the PRE protein may not
CC only serves a function in plasmid maintenance, but may also contributes
CC to the distribution of small antibiotic resistance plasmids among Gram-
CC positive bacteria. {ECO:0000250}.
CC -!- MISCELLANEOUS: Contains conserved positively charged amino acids
CC probably involved in the binding of the pre protein to the RSA site.
CC -!- SIMILARITY: Belongs to the plasmid mobilization pre family.
CC {ECO:0000305}.
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DR EMBL; BA000017; BAB56193.1; -; Genomic_DNA.
DR RefSeq; WP_000119405.1; NC_002758.2.
DR AlphaFoldDB; P0A0C5; -.
DR SMR; P0A0C5; -.
DR PaxDb; P0A0C5; -.
DR EnsemblBacteria; BAB56193; BAB56193; SAV0031.
DR GeneID; 64019866; -.
DR GeneID; 8153655; -.
DR KEGG; sav:SAV0031; -.
DR HOGENOM; CLU_035698_0_0_9; -.
DR OMA; VEDYFER; -.
DR BioCyc; SAUR158878:SAV_RS00305-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR InterPro; IPR001668; Mob_Pre.
DR Pfam; PF01076; Mob_Pre; 1.
PE 3: Inferred from homology;
KW DNA-binding.
FT CHAIN 1..420
FT /note="Plasmid recombination enzyme type 2"
FT /id="PRO_0000068421"
FT REGION 388..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 44
FT /ligand="DNA"
FT /ligand_id="ChEBI:CHEBI:16991"
FT /evidence="ECO:0000255"
FT BINDING 114
FT /ligand="DNA"
FT /ligand_id="ChEBI:CHEBI:16991"
FT /evidence="ECO:0000255"
SQ SEQUENCE 420 AA; 49660 MW; 76B16BD3A2B9689A CRC64;
MSYAVCRMQK VKSAGLKGMQ FHNQRERKSR TNDDIDHERT RENYDLKNDK NIDYNERVKE
IIESQKTGTR KTRKDAVLVN ELLVTSDRDF FEQLDPGEQK RFFEESYKLF SERYGKQNIA
YATVHNDEQT PHMHLGVVPM RDGKLQGKNV FNRQELLWLQ DKFPEHMKKQ GFELKRGERG
SDRKHIETAK FKKQTLEKEI DFLEKNLAVK KDEWTAYSDK VKSDLEVPAK RHMKSVEVPT
GEKSMFGLGK EIMKTEKKPT KNVVISERDY KNLVTAARDN DRLKQHVRNL MSTDMAREYK
KLSKEHGQVK EKYSGLVERF NENVNDYNEL LEENKSLKSK ISDLKRDVSL IYESTKEFLK
ERTDGLKAFK NVFKGFVDKV KDKTAQFQEK HDLEPKKNEF ELTHNREVKK ERSRDQGMSL