ID   PRE2_STAAU              Reviewed;         420 AA.
AC   P0A0C7; P22490; Q52091;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Plasmid recombination enzyme type 2;
DE   AltName: Full=Mobilization protein;
DE   AltName: Full=Plasmid recombinase;
GN   Name=pre; Synonyms=mob;
OS   Staphylococcus aureus.
OG   Plasmid pUB110.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pUB110;
RX   PubMed=3744038;
RA   Bashkirov V.I., Mil'Shina N.V., Prozorov A.A.;
RT   "Nucleotide sequence and physical map of kanamycin-resistant plasmid pUB110
RT   from Staphylococcus aureus.";
RL   Genetika 22:1081-1092(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pUB110;
RX   PubMed=3010356; DOI=10.1016/0147-619x(86)90046-6;
RA   McKenzie T., Hoshino T., Tanaka T., Sueoka N.;
RT   "The nucleotide sequence of pUB110: some salient features in relation to
RT   replication and its regulation.";
RL   Plasmid 15:93-103(1986).
RN   [3]
RP   SEQUENCE REVISION.
RC   PLASMID=pUB110;
RX   PubMed=3033723; DOI=10.1016/0147-619x(87)90015-1;
RA   McKenzie T., Hoshino T., Tanaka T., Sueoka N.;
RT   "Correction. A revision of the nucleotide sequence and functional map of
RT   pUB110.";
RL   Plasmid 17:83-85(1987).
CC   -!- FUNCTION: The interaction of the RSA site and the PRE protein may not
CC       only serves a function in plasmid maintenance, but may also contributes
CC       to the distribution of small antibiotic resistance plasmids among Gram-
CC       positive bacteria.
CC   -!- MISCELLANEOUS: Contains conserved positively charged amino acids
CC       probably involved in the binding of the pre protein to the RSA site.
CC   -!- SIMILARITY: Belongs to the plasmid mobilization pre family.
CC       {ECO:0000305}.
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DR   EMBL; M37273; AAA98212.1; -; Genomic_DNA.
DR   EMBL; M19465; AAA88359.1; -; Genomic_DNA.
DR   PIR; T44132; T44132.
DR   RefSeq; NP_040431.1; NC_001384.1.
DR   RefSeq; NP_863619.1; NC_005024.1.
DR   RefSeq; WP_000119405.1; NZ_WKGG01000017.1.
DR   RefSeq; YP_002790914.1; NC_012547.1.
DR   RefSeq; YP_006937660.1; NC_013320.1.
DR   AlphaFoldDB; P0A0C7; -.
DR   SMR; P0A0C7; -.
DR   GeneID; 64019866; -.
DR   GeneID; 8153655; -.
DR   OMA; VEDYFER; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   InterPro; IPR001668; Mob_Pre.
DR   Pfam; PF01076; Mob_Pre; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Plasmid.
FT   CHAIN           1..420
FT                   /note="Plasmid recombination enzyme type 2"
FT                   /id="PRO_0000068423"
FT   REGION          388..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         44
FT                   /ligand="DNA"
FT                   /ligand_id="ChEBI:CHEBI:16991"
FT                   /evidence="ECO:0000255"
FT   BINDING         114
FT                   /ligand="DNA"
FT                   /ligand_id="ChEBI:CHEBI:16991"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   420 AA;  49660 MW;  76B16BD3A2B9689A CRC64;
     MSYAVCRMQK VKSAGLKGMQ FHNQRERKSR TNDDIDHERT RENYDLKNDK NIDYNERVKE
     IIESQKTGTR KTRKDAVLVN ELLVTSDRDF FEQLDPGEQK RFFEESYKLF SERYGKQNIA
     YATVHNDEQT PHMHLGVVPM RDGKLQGKNV FNRQELLWLQ DKFPEHMKKQ GFELKRGERG
     SDRKHIETAK FKKQTLEKEI DFLEKNLAVK KDEWTAYSDK VKSDLEVPAK RHMKSVEVPT
     GEKSMFGLGK EIMKTEKKPT KNVVISERDY KNLVTAARDN DRLKQHVRNL MSTDMAREYK
     KLSKEHGQVK EKYSGLVERF NENVNDYNEL LEENKSLKSK ISDLKRDVSL IYESTKEFLK
     ERTDGLKAFK NVFKGFVDKV KDKTAQFQEK HDLEPKKNEF ELTHNREVKK ERSRDQGMSL