PRE5_ARATH
ID PRE5_ARATH Reviewed; 92 AA.
AC Q9LJX1; Q8L919;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transcription factor PRE5;
DE AltName: Full=Basic helix-loop-helix protein 164;
DE Short=AtbHLH164;
DE Short=bHLH 164;
DE AltName: Full=Protein PACLOBUTRAZOL RESISTANCE 5;
DE AltName: Full=bHLH transcription factor bHLH164;
GN Name=PRE5; Synonyms=BHLH164; OrderedLocusNames=At3g28857; ORFNames=MLD15.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16527868; DOI=10.1093/pcp/pcj026;
RA Lee S., Lee S., Yang K.Y., Kim Y.M., Park S.Y., Kim S.Y., Soh M.S.;
RT "Overexpression of PRE1 and its homologous genes activates gibberellin-
RT dependent responses in Arabidopsis thaliana.";
RL Plant Cell Physiol. 47:591-600(2006).
RN [6]
RP INTERACTION WITH IBH1.
RX PubMed=23161888; DOI=10.1105/tpc.112.105023;
RA Ikeda M., Fujiwara S., Mitsuda N., Ohme-Takagi M.;
RT "A triantagonistic basic helix-loop-helix system regulates cell elongation
RT in Arabidopsis.";
RL Plant Cell 24:4483-4497(2012).
CC -!- FUNCTION: Atypical and probable non DNA-binding bHLH transcription
CC factor that integrates multiple signaling pathways to regulate cell
CC elongation and plant development. May have a regulatory role in various
CC aspects of gibberellin-dependent growth and development.
CC {ECO:0000269|PubMed:16527868}.
CC -!- SUBUNIT: Interacts with IBH1. {ECO:0000269|PubMed:23161888}.
CC -!- INTERACTION:
CC Q9LJX1; Q9M0B9: IBL1; NbExp=5; IntAct=EBI-15195291, EBI-15192969;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- MISCELLANEOUS: Plants over-expressing PRE5 show long hypocotyls, pale
CC green and slightly narrow leaves, elongated petioles and early
CC flowering. They are not sensitive to the gibberellin inhibitor
CC paclobutrazol during seed germination (PubMed:16527868).
CC {ECO:0000305|PubMed:16527868}.
CC -!- SIMILARITY: Belongs to the bHLH protein family. {ECO:0000305}.
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DR EMBL; AP000386; BAB02128.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77497.1; -; Genomic_DNA.
DR EMBL; BT024640; ABD57465.1; -; mRNA.
DR EMBL; AY088680; AAM67002.1; -; mRNA.
DR RefSeq; NP_974372.1; NM_202643.2.
DR AlphaFoldDB; Q9LJX1; -.
DR SMR; Q9LJX1; -.
DR BioGRID; 30502; 10.
DR IntAct; Q9LJX1; 10.
DR STRING; 3702.AT3G28857.1; -.
DR PaxDb; Q9LJX1; -.
DR PRIDE; Q9LJX1; -.
DR ProteomicsDB; 236599; -.
DR EnsemblPlants; AT3G28857.1; AT3G28857.1; AT3G28857.
DR GeneID; 2745895; -.
DR Gramene; AT3G28857.1; AT3G28857.1; AT3G28857.
DR KEGG; ath:AT3G28857; -.
DR Araport; AT3G28857; -.
DR TAIR; locus:1006230235; AT3G28857.
DR eggNOG; ENOG502S648; Eukaryota.
DR HOGENOM; CLU_183267_0_0_1; -.
DR InParanoid; Q9LJX1; -.
DR OMA; QETCKYV; -.
DR OrthoDB; 1589357at2759; -.
DR PhylomeDB; Q9LJX1; -.
DR PRO; PR:Q9LJX1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJX1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR044293; PRE.
DR PANTHER; PTHR46446; PTHR46446; 1.
DR Pfam; PF00010; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Gibberellin signaling pathway; Growth regulation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..92
FT /note="Transcription factor PRE5"
FT /id="PRO_0000429086"
FT DOMAIN 4..59
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 92 AA; 10699 MW; CF50716877A04D59 CRC64;
MSNRRSRQTS NASRISDDQM IDLVSKLRQF LPEIHERRRS DKVSASKVLQ ETCNYIRKLH
REVDNLSDRL SQLLDSVDED SPEAAVIRSL LM
