PREG_NEUCR
ID PREG_NEUCR Reviewed; 483 AA.
AC Q06712; Q7RV69;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Nuc-1 negative regulatory protein preg;
DE AltName: Full=Phosphatase regulation protein;
GN Name=preg; ORFNames=B24H17.120, NCU01738;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 18889 / 74-OR8-1a / 40-21 / DSM 1258 / FGSC 988;
RX PubMed=8436269; DOI=10.1093/genetics/133.2.193;
RA Kang S., Metzenberg R.L.;
RT "Insertional mutagenesis in Neurospora crassa: cloning and molecular
RT analysis of the preg+ gene controlling the activity of the transcriptional
RT activator NUC-1.";
RL Genetics 133:193-202(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Negative regulator, together with pgov, of the
CC transcriptional activator nuc-1, which controls the expression of
CC phosphorous acquisition enzymes.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR EMBL; L07314; AAA74959.1; -; Genomic_DNA.
DR EMBL; AL356815; CAB92634.1; -; Genomic_DNA.
DR EMBL; CM002237; EAA27925.3; -; Genomic_DNA.
DR PIR; S52974; S52974.
DR RefSeq; XP_957161.3; XM_952068.3.
DR AlphaFoldDB; Q06712; -.
DR SMR; Q06712; -.
DR STRING; 5141.EFNCRP00000001709; -.
DR EnsemblFungi; EAA27925; EAA27925; NCU01738.
DR GeneID; 3873354; -.
DR KEGG; ncr:NCU01738; -.
DR VEuPathDB; FungiDB:NCU01738; -.
DR HOGENOM; CLU_023749_0_0_1; -.
DR InParanoid; Q06712; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR013922; Cyclin_PHO80-like.
DR PANTHER; PTHR15615; PTHR15615; 1.
DR Pfam; PF08613; Cyclin; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Cyclin; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..483
FT /note="Nuc-1 negative regulatory protein preg"
FT /id="PRO_0000080508"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..468
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 394
FT /note="L->P: In ML207; loss of function."
FT MUTAGEN 398
FT /note="E->Q: In ML178; loss of function."
SQ SEQUENCE 483 AA; 51479 MW; B583E4469CD980A0 CRC64;
MLTRSPASAA ATSPTTTVTV TVTAAATSPR PSRGAAPHGH FHYAPTPSLR EAASRIPALS
SRRQSATAPA TSSTSLPISI QSRHGPAPVA SHTSSPVASD PGLGFPPSSR PQRWAGVDVV
AQYSPMEPMD YTTGALLSSQ AASSSNNQAV ARGSIESRPS HIPNTVGPMA SHEEQASALA
STSEATAAPI PHGPTVAVAV PPTPGVYSAA PQPHPLSHTP QTGTPVKRRN SQGDVTHNQV
EAASAGQSGP HSPKRARLAP KIVSRRYEHC PVEDLVVLIA HMLGELIELN DEAAQKVGQR
HNLTRFHSRT TPGISVLDYL HRLAKHAYLS PPILLSMVYY IDRLCALYSD FTINTLTVHR
FLITAATVAA KGLSDSFLTN TLYARVGGVR VAELNMLELE FLHRVDWKIV PDPDVLVAYY
GGLVARCPGY ILECPEPEEA DDEDEDEELD ESDAIGDDDD DIDGEGGERE EETSSSQRDR
HAT
