PREL_DROME
ID PREL_DROME Reviewed; 236 AA.
AC Q9V579; Q95RE6;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein preli-like;
GN Name=prel; ORFNames=CG8806;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15700158; DOI=10.1007/s00427-005-0470-4;
RA Dee C.T., Moffat K.G.;
RT "A novel family of mitochondrial proteins is represented by the Drosophila
RT genes slmo, preli-like and real-time.";
RL Dev. Genes Evol. 215:248-254(2005).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=19855018; DOI=10.1242/dev.042135;
RA Tsubouchi A., Tsuyama T., Fujioka M., Kohda H., Okamoto-Furuta K.,
RA Aigaki T., Uemura T.;
RT "Mitochondrial protein Preli-like is required for development of dendritic
RT arbors and prevents their regression in the Drosophila sensory nervous
RT system.";
RL Development 136:3757-3766(2009).
CC -!- FUNCTION: Involved in maintaining the structural and functional
CC integrity of mitochondria (PubMed:19855018). Activity is required for
CC maintaining the subcellular distribution, shape and activity of
CC mitochondria in neurons and as a consequence has an important role in
CC the development and maintenance of dendritic arbors (PubMed:19855018).
CC Function may be particularly important in class IV dendritic
CC arborization (da) neurons (PubMed:19855018).
CC {ECO:0000269|PubMed:19855018}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15700158,
CC ECO:0000269|PubMed:19855018}. Note=Detected at the mitochondria
CC cristae. {ECO:0000269|PubMed:19855018}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15700158}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the earliest stages of development,
CC and is ubiquitous throughout embryonic development (PubMed:15700158).
CC At stage 16, it is strongly up-regulated in the developing brain lobes,
CC but not in the ventral nerve cord (PubMed:15700158). Also up-regulated
CC in specific regions of the midgut (PubMed:15700158). Expressed during
CC all subsequent developmental stages from first instar larvae through to
CC adulthood (PubMed:15700158). In larvae, expressed in dendritic
CC arborization (da) neurons, with highest levels of expression in class
CC IV neurons compared to the other da classes (PubMed:19855018).
CC {ECO:0000269|PubMed:15700158, ECO:0000269|PubMed:19855018}.
CC -!- DISRUPTION PHENOTYPE: Lethal at early larval stages.
CC {ECO:0000269|PubMed:19855018}.
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DR EMBL; AE013599; AAF58939.3; -; Genomic_DNA.
DR EMBL; AY061437; AAL28985.1; -; mRNA.
DR EMBL; BT001703; AAN71458.1; -; mRNA.
DR RefSeq; NP_001260824.1; NM_001273895.1.
DR RefSeq; NP_610487.3; NM_136643.4.
DR AlphaFoldDB; Q9V579; -.
DR SMR; Q9V579; -.
DR BioGRID; 61800; 4.
DR IntAct; Q9V579; 3.
DR STRING; 7227.FBpp0289521; -.
DR PaxDb; Q9V579; -.
DR PRIDE; Q9V579; -.
DR DNASU; 35969; -.
DR EnsemblMetazoa; FBtr0300293; FBpp0289521; FBgn0033413.
DR EnsemblMetazoa; FBtr0333003; FBpp0305218; FBgn0033413.
DR GeneID; 35969; -.
DR KEGG; dme:Dmel_CG8806; -.
DR UCSC; CG8806-RB; d. melanogaster.
DR CTD; 35969; -.
DR FlyBase; FBgn0033413; prel.
DR VEuPathDB; VectorBase:FBgn0033413; -.
DR eggNOG; KOG3337; Eukaryota.
DR GeneTree; ENSGT00950000182810; -.
DR HOGENOM; CLU_067902_3_0_1; -.
DR InParanoid; Q9V579; -.
DR OMA; LAFFNRY; -.
DR OrthoDB; 1369397at2759; -.
DR PhylomeDB; Q9V579; -.
DR Reactome; R-DME-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR BioGRID-ORCS; 35969; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 35969; -.
DR PRO; PR:Q9V579; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033413; Expressed in brain and 12 other tissues.
DR ExpressionAtlas; Q9V579; baseline and differential.
DR Genevisible; Q9V579; DM.
DR GO; GO:0030061; C:mitochondrial crista; IDA:FlyBase.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:1990050; F:phosphatidic acid transfer activity; IBA:GO_Central.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0070584; P:mitochondrion morphogenesis; IMP:FlyBase.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR InterPro; IPR006797; PRELI/MSF1_dom.
DR InterPro; IPR037365; Slowmo/Ups.
DR PANTHER; PTHR11158; PTHR11158; 1.
DR Pfam; PF04707; PRELI; 1.
DR PROSITE; PS50904; PRELI_MSF1; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..236
FT /note="Protein preli-like"
FT /id="PRO_0000058569"
FT DOMAIN 5..171
FT /note="PRELI/MSF1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
SQ SEQUENCE 236 AA; 26273 MW; 170ED232D84167FE CRC64;
MVVAASTCRT ETVFDYSWMN VVVAYWNRYP NPSSTHVLTE DTIQREVRDG KLFSRRLLSK
TNPVPKWGAR FYNNVPVKIV EDSVLDPVKK TFTTFTRNLG MTKIMKVDEI VVYSEQKDGS
TLAVRRAYIS SQVFGFSRAI RAFGIERFKA NGNKASNGFN YVLRRMFPDS LVGGGHHQHA
VTTTSPAGEL PATTITVSTT NGSLNNQGAL KSAAKVGYEF FKSHASKIAQ LFSVKN
