PREY_HUMAN
ID PREY_HUMAN Reviewed; 114 AA.
AC Q96I23; B2R571;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein preY, mitochondrial;
DE AltName: Full=PIGY upstream reading frame protein;
DE Flags: Precursor;
GN Name=PYURF; Synonyms=PREY;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION.
RX PubMed=16162815; DOI=10.1091/mbc.e05-08-0743;
RA Murakami Y., Siripanyaphinyo U., Hong Y., Tashima Y., Maeda Y.,
RA Kinoshita T.;
RT "The initial enzyme for glycosylphosphatidylinositol biosynthesis requires
RT PIG-Y, a seventh component.";
RL Mol. Biol. Cell 16:5236-5246(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- MISCELLANEOUS: PREY and PIGY, 2 apparently unrelated proteins, are
CC respectively the product of an upstream and a downstream ORF contained
CC in a single bicistronic transcript.
CC -!- SIMILARITY: Belongs to the PREY family. {ECO:0000305}.
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DR EMBL; AK312082; BAG35018.1; -; mRNA.
DR EMBL; AB206972; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC007876; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS3631.1; -.
DR RefSeq; NP_116295.1; NM_032906.4.
DR AlphaFoldDB; Q96I23; -.
DR SMR; Q96I23; -.
DR BioGRID; 3190614; 7.
DR IntAct; Q96I23; 3.
DR STRING; 9606.ENSP00000273968; -.
DR PhosphoSitePlus; Q96I23; -.
DR BioMuta; PYURF; -.
DR DMDM; 74732012; -.
DR EPD; Q96I23; -.
DR jPOST; Q96I23; -.
DR MassIVE; Q96I23; -.
DR MaxQB; Q96I23; -.
DR PaxDb; Q96I23; -.
DR PeptideAtlas; Q96I23; -.
DR PRIDE; Q96I23; -.
DR ProteomicsDB; 76804; -.
DR TopDownProteomics; Q96I23; -.
DR Antibodypedia; 25633; 19 antibodies from 10 providers.
DR DNASU; 100996939; -.
DR Ensembl; ENST00000273968.5; ENSP00000273968.4; ENSG00000145337.5.
DR GeneID; 100996939; -.
DR KEGG; hsa:100996939; -.
DR MANE-Select; ENST00000273968.5; ENSP00000273968.4; NM_032906.5; NP_116295.1.
DR UCSC; uc003hru.3; human.
DR CTD; 100996939; -.
DR DisGeNET; 100996939; -.
DR GeneCards; PYURF; -.
DR HGNC; HGNC:44317; PYURF.
DR HPA; ENSG00000145337; Low tissue specificity.
DR MalaCards; PYURF; -.
DR neXtProt; NX_Q96I23; -.
DR OpenTargets; ENSG00000145337; -.
DR PharmGKB; PA143485576; -.
DR VEuPathDB; HostDB:ENSG00000145337; -.
DR eggNOG; ENOG502S7H4; Eukaryota.
DR GeneTree; ENSGT00390000015889; -.
DR HOGENOM; CLU_155659_0_0_1; -.
DR InParanoid; Q96I23; -.
DR OMA; RMIHQNK; -.
DR OrthoDB; 1619084at2759; -.
DR PhylomeDB; Q96I23; -.
DR PathwayCommons; Q96I23; -.
DR SignaLink; Q96I23; -.
DR BioGRID-ORCS; 100996939; 170 hits in 1037 CRISPR screens.
DR ChiTaRS; PYURF; human.
DR GenomeRNAi; 100996939; -.
DR Pharos; Q96I23; Tdark.
DR PRO; PR:Q96I23; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q96I23; protein.
DR Bgee; ENSG00000145337; Expressed in islet of Langerhans and 95 other tissues.
DR Genevisible; Q96I23; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:HGNC-UCL.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01187; UPF0434; 1.
DR InterPro; IPR005651; Trm112-like.
DR Pfam; PF03966; Trm112p; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..35
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 36..114
FT /note="Protein preY, mitochondrial"
FT /id="PRO_0000246315"
FT DOMAIN 51..97
FT /note="TRM112"
FT REGION 14..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 114 AA; 12655 MW; B7A33E980FC61A3E CRC64;
MLSGARCRLA SALRGTRAPP SAVARRCLHA SGSRPLADRG KKTEEPPRDF DPALLEFLVC
PLSKKPLRYE ASTNELINEE LGIAYPIIDG IPNMIPQAAR MTRQSKKQEE VEQR
